Hyperleptinaemia
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Changes on adult male rats in models of programming induced by hyperleptinaemia during lactation / Alterações neuro-comportamentais em ratos machos adultos em modelos de programação pela hiperleptinemia na lactação
A considerable association exists between variations in nutritional, hormonal and environmental parameters during early life, particularly in the gestational and lactation periods, and the appearance of chronic diseases in adult life, such as obesity, diabetes, cardiovascular diseases, anxiety and depression. In the present study, the cognitive and behaviora
Publicado em: 2009
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2. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
Pre- and neonatal overfeeding programmes a permanent obesity disposition and accompanying diabetic and cardiovascular disorders, by unknown mechanisms. We proposed that early overfeeding may alter DNA methylation patterns of hypothalamic promoter regions of genes critically involved in the lifelong regulation of food intake and body weight. We induced neonat
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3. Maternal prolactin inhibition during lactation programs for metabolic syndrome in adult progeny
Neonatal malnutrition is associated with metabolic syndrome in adulthood. Maternal hypoprolactinaemia at the end of lactation (a precocious weaning model) caused obesity, leptin resistance and hypothyroidism in adult offspring, suggesting an association of prolactin (PRL) and programming of metabolic dysfunctions. Metabolic syndrome pathogenesis is still unc
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4. Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
Hormone potency depends on receptor availability, regulated via gene expression and receptor trafficking. To ascertain how central leptin receptors are regulated, the effects of leptin challenge, high-fat diet, fasting and refeeding were measured on leptin receptor number and gene expression. These were measured using quantitative 125I-labelled leptin in vit
Blackwell Science Inc.
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5. Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic–pituitary–thyroid axis of young and adult rats
Postnatal early overnutrition (EO) is a risk factor for obesity in adult life. Rats raised in a small litter can develop hyperinsulinaemia, hyperphagia, hyperleptinaemia and hypertension as adults. Since leptin regulates the hypothalamic–pituitary–thyroid axis and the metabolism of thyroid hormones, we studied the leptin signalling pathway in pituitary a
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