Hypercholesterolaemia
Mostrando 1-12 de 88 artigos, teses e dissertações.
-
1. Evaluation of Reference Genes for Quantitative PCR in Four Tissues from Rabbits with Hypercholesterolaemia
Abstract Rabbit with hypercholesterolaemia is an important model for studying cholesterol metabolism disease. This study aimed to evaluate the expression stability of nine reference genes for quantitative PCR (qPCR) analysis in adrenal gland, liver, spleen, and kidney tissue from rabbits with hypercholesterolaemia. In total, 30 male Harbin Large White (HLW)
Braz. arch. biol. technol.. Publicado em: 20/12/2019
-
2. ATIVIDADE HIPOLIPIDÊMICA DO DISSELENETO DE DIFENILA NA HIPERLIPIDEMIA INDUZIDA POR TRITON WR-1339 EM CAMUNDONGOS / HYPOLIPIDAEMIC ACTIVITY OF DIPHENYL DISELENIDE IN TRITON WR-1339-INDUCED HYPERLIPIDAEMIA IN MICE.
In mammals, the liver plays a central role in whole-body lipid metabolism. Unfortunately, dysregulation of these pathways has been implicated in hyperlipidemias. In recent years, a significant association between the trace element selenium and hypercholesterolaemia in human and animals has been reported. This study was designed to investigate a potential hyp
Publicado em: 2009
-
3. Hábitos alimentares de idosos hipercolesterolêmicos, atendidos em ambulatório da cidade de São Paulo / Dietary habits of hypercholesterolaemic elderly patients attending to an ambulatory unity in São Paulo city
Introdução: Hábitos alimentares (HAs) inadequados têm importante relação com hipercolesterolemia, que constitui fator de risco para doenças cardiovasculares. Objetivo: Analisar HAs de idosos hipercolesterolêmicos, atendidos em ambulatório da cidade de São Paulo. Métodos: Participaram do estudo idosos ( 60 anos), de ambos os sexos, voluntários, co
Publicado em: 2009
-
4. Lipid lowering and polymorphisms effects on the expression of HMGCR, LDLR, SREBF1a, SREBF2, SCAP and NPC1L1 genes in hypercholesterolemic subjects. / Efeitos de hipolipemiantes e polimorfismos sobre a expressão dos genes HMGCR, LDLR, SREBF1a, SREBF2, SCAP e NPC1L1 em indivíduos hipercolesterolêmicos.
A homeostase do colesterol é mediada por proteínas envolvidas na absorção (NPC1L1), regulação (SREBP1, SREBP2, SCAP), síntese (HMGCR) e remoção plasmática (LDLR). Os fármacos inibidores da síntese (vastatinas) e absorção (ezetimiba) do colesterol são potentes agentes hipocolesterolemiantes. Alterações em vários genes têm sido associadas a
Publicado em: 2008
-
5. Assessment of clinical and nutritional parameters in subjects with heterozygous familial hypercholesterolaemia / "Avaliação de parâmetros clínicos e nutricionais em pacientes com hipercolesterolemia familiar heterozigótica"
Familial hypercholesterolaemia (FH) is characterized by raised concentrations of LDL-c and high prevalence of premature coronary artery disease (CAD). However, the course of the CAD in the FH is variable and can be influenced by other risk factors. The aim of the study was to assess clinical and nutritional parameters in adults with heterozigous FH by a cros
Publicado em: 2006
-
6. Hypercholesterolaemia and diabetes mellitus
An association of essential hypercholesterolaemia and diabetes mellitus is postulated. Case records are included to illustrate hypercholesterolaemia secondary to acute diabetes mellitus, and essential hypercholesterolaemia, independent of, but accompanying diabetes mellitus. Whereas in the former the serum cholesterol returns to normal and its attendant clin
-
7. Articular manifestations of familial hypercholesterolaemia.
Familial hypercholesterolaemia is characterised by a decreased removal of low density lipoproteins and premature coronary artery disease. Tendinous xanthomata are a hallmark of the disease. The affected joints may also be the sites of inflammation and pain. Arthropathy has been associated mainly with the homozygous form of familial hypercholesterolaemia, but
-
8. Musculoskeletal manifestations in hyperlipidaemia: a controlled study.
Eighty eight patients with hyperlipidaemia (81 white patients from South Africa and seven patients of mixed race from the West Cape area) were studied. Forty eight had adult familial hypercholesterolaemia, 16 had juvenile familial hypercholesterolaemia, and 24 had mixed hyperlipidaemia (increased cholesterol and triglycerides). They were interviewed and exam
-
9. Cholesterol screening and family history of vascular disease.
Hypercholesterolaemia is a major risk factor for the development of coronary heart disease (CHD). Early detection and management of hypercholesterolaemia could retard the atherosclerotic process. Given that CHD and hypercholesterolaemia cluster within families, a screening strategy based on a family history of vascular disease has been advocated. Serum total
-
10. Familial hypercholesterolaemia: pilot study to identify children at risk.
AIMS--To evaluate a more effective method of identifying children with familial hypercholesterolaemia by screening a population at high risk. METHODS--Domiciliary measurement of random cholesterol concentration was made in 200 children who were first or second degree relatives of subjects with premature onset coronary artery disease. Measurements were taken
-
11. Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia.
Haemostatic variables were measured in 61 patients with heterozygous familial hypercholesterolaemia, 32 of whom had evidence of coronary heart disease. Age adjusted mean concentrations of plasma fibrinogen and factor VIII were significantly higher in these patients than in the 29 patients without coronary heart disease, but there were no significant differen
-
12. Treatment of the arthropathy of familial hypercholesterolaemia.
A 29-year-old woman suffering from the arthropathy of familial hypercholesterolaemia was treated with a fat-modified low-cholesterol diet and colestipol. Symptomatic improvement occurred in association with a moderate reduction in the plasma cholesterol concentration. The pathogenesis of the musculoskeletal features of this disease is reviewed, and the impli