Hydroxyurea
Mostrando 1-12 de 447 artigos, teses e dissertações.
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1. 2-(Pyridin-4yl)benzothiazole and Its Benzimidazole-Analogue: Biophysical and in silico Studies on Their Interaction with Urease and in vitro Anti-Helicobacter pylori Activities
In this study, the interaction between benzothiazole (BTA, concentration of a drug required for 50% inhibition in vitro (IC50) = 0.77 mM) and benzimidazole (BIA, IC50 = 2.14 mM) with urease was quantitatively assessed, using UV-Vis, molecular fluorescence, and circular dichroism. The results showed that both compounds interact with urease by a static fluores
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Follow-up of children with sickle cell anemia screened with transcranial Doppler and enrolled in a primary prevention program of ischemic stroke
ABSTRACT Background: Stroke is a serious complication of sickle cell anemia (SCA). The transcranial Doppler (TCD) is the risk-screening tool for ischemic strokes. The objective of the study was to describe the clinical progression of children with SCA who presented with high risk for stroke by TCD or relevant changes by magnetic resonance angiography (MRA)
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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3. Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease
RESUMO Objetivo Avaliar o efeito da indução de danos ao DNA em células monocelulares do sangue periférico de pacientes com doença falciforme, genótipos SS e SC, tratados com hidroxiureia. Métodos Os sujeitos da pesquisa foram divididos em dois grupos: um de 22 pacientes com doença falciforme genótipos SS e SC tratados com hidroxiureia, e o outro c
Einstein (São Paulo). Publicado em: 09/09/2019
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4. Essential thrombocythemia - a predisponent factor for stroke
SUMMARY The essential thrombocythemia is one of the seven described forms of myeloproliferative neoplasms. It is characterized by megakaryocytic hyperplasia with consequent thrombocytosis maintained in the peripheral blood, favoring the occurrence of thrombo-hemorrhagic phenomena. We present the case of an 81-year-old woman with a history of ischemic stroke
Rev. Assoc. Med. Bras.. Publicado em: 22/07/2019
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5. Management of chronic myeloid leukemia during pregnancy: a retrospective analysis at a single center
ABSTRACT We analyzed the management and outcomes of pregnancies of patients with chronic myeloid leukemia at a single center over fifteen years. Among the 203 CML female patients, there were ten pregnancies in seven women, all of them not planned. In three cases, the chronic myeloid leukemia diagnosis was made during pregnancy. Five patients received tyrosin
Hematol., Transfus. Cell Ther.. Publicado em: 10/06/2019
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6. Effect of hydroxyurea (HU) on gelatinization mechanism of type I collagen suspensions
ABSTRACT Mutant hemoglobins thermodynamic phase transitions (HbS, HbC, etc.) have been the causes of serious hemoglobinopathies that have been affecting mankind since the dawn of human race. HbS polymerization is the best known of these transitions and the original cause of sickle cell anemia. Hydroxyurea (HU, NH2CONHOH) is widely used as the main drug admin
Matéria (Rio J.). Publicado em: 06/12/2018
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7. Case for diagnosis. Erythroderma as manifestation of hypereosinophilic syndrome
Abstract: Hypereosinophilic syndrome is defined as persistent eosinophilia (>1500/µL for more than six months) associated with organ involvement, excluding secondary causes. It is a rare, potentially lethal disease that should be considered in cutaneous conditions associated with hypereosinophilia. We report a case of erythroderma as a manifestation of hype
An. Bras. Dermatol.. Publicado em: 2018-06
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8. Telomere length correlates with disease severity and inflammation in sickle cell disease
ABSTRACT Background: Telomeres, the ends of linear chromosomes, shorten during mitotic cell division and erosion may be aggravated by inflammation or proliferative and oxidative stress. As the bone marrow is under hyperproliferative pressure in sickle cell disease and several tissues are submitted to chronic inflammation, this study sought to determine the
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-06
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9. A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia
Abstract Background: Treatment of sickle cell anemia is a challenging task and despite the well understood genetic and biochemical pathway of sickle hemoglobin, current therapy continues to be limited to the symptomatic treatment of pain, supplemental oxygen, antibiotics, red blood cell transfusions and hydroxyurea. SANGUINATE is a carbon monoxide releasing
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03
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10. Clinical and laboratory profile of patients with sickle cell anemia
Abstract Objective: This study aimed to describe and analyze clinical and laboratory characteristics of patients with sickle cell anemia treated at the Hemominas Foundation, in Divinópolis, Brazil. Furthermore, this study aimed to compare the clinical and laboratory outcomes of the group of patients treated with hydroxyurea with those patients that were no
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03
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11. Cholelithiasis and its complications in sickle cell disease in a university hospital
Abstract Introduction: The clinical manifestations of sickle cell disease are related to the polymerization of hemoglobin S. The chronic hemolysis caused by this condition often causes the formation of gallstones that can migrate and block the common bile duct leading to acute abdomen. Objective: This study aimed to evaluate the profile of patients with si
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03
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12. Mortality by sickle cell disease in Brazil
Abstract This work aimed to characterize mortality by sickle cell disease in Brazil. The MEDLINE electronic database was searched using the terms ‘mortality' and ‘sickle cell disease' and ‘Brazil' for articles published in the last five years aiming to provide a current analysis of the subject in question. Eight studies on mortality by sickle cell dise
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-03