Hydrophobic Interaction
Mostrando 1-12 de 822 artigos, teses e dissertações.
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1. 2-(Pyridin-4yl)benzothiazole and Its Benzimidazole-Analogue: Biophysical and in silico Studies on Their Interaction with Urease and in vitro Anti-Helicobacter pylori Activities
In this study, the interaction between benzothiazole (BTA, concentration of a drug required for 50% inhibition in vitro (IC50) = 0.77 mM) and benzimidazole (BIA, IC50 = 2.14 mM) with urease was quantitatively assessed, using UV-Vis, molecular fluorescence, and circular dichroism. The results showed that both compounds interact with urease by a static fluores
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. In silico prediction of inhibitory potential of a punicalagin β-anomer against SARS-COV-2 main protease (MPRO)
The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main pr
Química Nova. Publicado em: 2022
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3. Spectroscopic techniques combined with chemometrics to study organic matter in tropical soils with different degrees of pedogenetic evolution
Understanding of the organomineral interactions in soil can elucidate the humic substances (HS) formation and the humification process. This study aimed to structurally characterize the humic acids (HA) formed in tropical soils with different pedogenesis degrees. The HA fraction was extracted from soil samples in the superficial horizons of an Inceptisol and
Química Nova. Publicado em: 2022
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4. Adhesion evaluation of the Rhodococcus opacus strain on an apatite surface
Abstract Adsorption of microorganisms and/or their different components onto a mineral surface would modify the surface characteristics of the mineral. Thus, this investigation evaluated the adsorption capacity of the Rhodococcus opacus strain onto an apatite surface. Zeta potential and contact angle measurements of the mineral showed dislocations of the val
REM, Int. Eng. J.. Publicado em: 2021-09
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5. Fundamental bioflotation aspects of hematite using an extracted Rhodococcus opacus by-product
Abstract The aim of this study is to assess the floatability of hematite using a crude biosurfactant (BS) extracted from Rhodococcus opacus. Throughout high-pressure ethanol extraction, unrefined surfactant was extracted from the bacteria with a yield of 0.3 g/L. An FTIR analysis on this extract, shows the presence of alcohol (–OH) and ketone (C=O) groups,
REM, Int. Eng. J.. Publicado em: 2021-09
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6. Chemical and Spectroscopic Characteristics of Anthrosol (Amazonian Dark Earth) and Surrounding Soil from the Brazilian Amazon Forest: Evaluation of Mineral and Organic Matter Content by Depth
The chemical and spectroscopic characteristics of soil organic matter (SOM) isolated from Amazonian dark earth (ADE) and surrounding soil (SR) were evaluated according to the soil depth. The results showed opposite trends for the soils. While ADE featured SOM with a greater aromatic condensation degree and greater hydrophobicity in the top layer, the SR show
J. Braz. Chem. Soc.. Publicado em: 2020-08
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7. SOCIOLOGIA SAGRADA
Benzbromarone (BZB) is a drug that has diuretic activity and is used in the gout treatment. Its therapeutic efficiency is decreased by its low water solubility (11.8 mg L-1) and highly hydrophobic aspect (logP 2.7), which are responsible for affecting its intestinal absorption and bioavailability. BZB inclusion complex (IC) aims at increasing the drug solubi
Sociol. Antropol.. Publicado em: 2020-08
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8. Preparation and Characterization of the β-Cyclodextrin Inclusion Complex with Benzbromarone
Benzbromarone (BZB) is a drug that has diuretic activity and is used in the gout treatment. Its therapeutic efficiency is decreased by its low water solubility (11.8 mg L-1) and highly hydrophobic aspect (logP 2.7), which are responsible for affecting its intestinal absorption and bioavailability. BZB inclusion complex (IC) aims at increasing the drug solubi
J. Braz. Chem. Soc.. Publicado em: 2020-08
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9. Rheological properties of low-density polyethylene filled with hydrophobic Co(Ni)-Al layered double hydroxides
Abstract Cobalt/aluminum and nickel/aluminum layered double hydroxide (LDH - M+2:Al molar ratio of 3:1) were intercalated with dodecylsulphate (DDS), laurate (LAU), stearate (STE) and palmitate (PAL) and used as filler in low-density polyethylene (LDPE) in percentages between 0.2 and 7.0wt%. After injection molding, the samples were submitted to morphologic
Polímeros. Publicado em: 01/04/2019
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10. Multiple Spectroscopic and Theoretical Approaches to Study the Interaction between HSA and the Antiparasitic Drugs: Benznidazole, Metronidazole, Nifurtimox and Megazol
The interaction between four antiparasitic drugs (benznidazole (BZL), metronidazole (MTZ), nifurtimox (NFX) and megazol (MZ)) with human serum albumin (HSA), the main vehicle of biodistribution of xenobiotics, hydrophobic, small and endogenous molecules in the bloodstream, was evaluated by multiple spectroscopic techniques and theoretical calculations. In al
J. Braz. Chem. Soc.. Publicado em: 2018-07
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11. Surface, thermal and hemocompatible properties of novel single stage electrospun nanocomposites comprising polyurethane blended with bio oilTM
ABSTRACT In this work, the physicochemical and blood compatibility properties of prepared PU/Bio oil nanocomposites were investigated. Scanning electron microscope (SEM) studies revealed the reduction of mean fiber diameter (709 ± 211 nm) compared to the pristine PU (969 nm ± 217 nm). Fourier transform infrared spectroscopy (FTIR) analysis exposed the char
An. Acad. Bras. Ciênc.. Publicado em: 26/10/2017
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12. Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling
BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES The aim of this work was to perform molecular modelling studies of 2-hydroxy-1,4-naphthoquinones
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-04