Hyaluronan
Mostrando 37-48 de 118 artigos, teses e dissertações.
-
37. Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.
OBJECTIVE--To determine the safety and efficacy of intra-articular injections of hyaluronan in the treatment of osteoarthritis of the knee. METHODS--A randomised double-blind placebo-controlled trial was carried out on 91 patients with radiologically confirmed osteoarthritis of the knee who were recruited from the outpatient clinics. RESULTS--It was found th
-
38. Uridine diphosphoglucose dehydrogenase activity in synovial lining cells in the experimental antigen induced model of rheumatoid arthritis: an indication of synovial lining cell function.
Uridine diphosphoglucose dehydrogenase (UDPGD) is the enzyme responsible for the production of uridine diphospho(UDP)-glucuronate, an essential monosaccharide in the biosynthesis of hyaluronan, which is found in high concentrations in normal synovial fluid. Synovial lining cells have been implicated in the synthesis of hyaluronan, but the degree to which the
-
39. Functions of hyaluronan.
-
40. RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy
We report here that joint inflammation in collagen-induced arthritis is more aggravated in CD44-knockout mice than in WT mice, and we provide evidence for molecular redundancy as a causal factor. Furthermore, we show that under the inflammatory cascade, RHAMM (receptor for hyaluronan-mediated motility), a hyaluronan receptor distinct from CD44, compensates f
National Academy of Sciences.
-
41. Hyaluronan is not just a goo!
American Society for Clinical Investigation.
-
42. Roles of hyaluronan in bone resorption
BioMed Central.
-
43. Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion.
The localization of circulating leukocytes within inflamed tissues occurs as the result of interactions with and migration across vascular endothelium, and is governed, in part, by the expression of adhesion molecules on both cell types. Recently, we have described a novel primary adhesion interaction between the structurally activated form of the adhesion m
-
44. A pathological role for damaged hyaluronan in synovitis.
-
45. Migration of bovine aortic smooth muscle cells after wounding injury. The role of hyaluronan and RHAMM.
The migration of smooth muscle cells is a critical event in the pathogenesis of vascular diseases. We have investigated the role of hyaluronan (HA) and the hyaluronan receptor RHAMM in the migration of adult bovine aortic smooth muscle cells (BASMC). Cultured BASMC migrated from the leading edge of a single scratch wound with increased velocity between 1 and
-
46. Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development.
-
47. Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin–cAMP pathway
Blackwell Publishing Ltd.
-
48. Effect of synovial fluid hyaluronan on the clearance of albumin from the canine knee.