Human Mechanics
Mostrando 25-36 de 52 artigos, teses e dissertações.
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25. The Contractile Properties of Human Heart Muscle: Studies on Myocardial Mechanics of Surgically Excised Papillary Muscles*
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26. Principles of Fluid Mechanics Applied to Some Situations in the Human Circulation and particularly to the Testing of Valves in a Pulse Duplicator
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27. The effects of isolation on the mechanics of the human heel pad.
In previous studies on the mechanical properties of the human heel pad (Bennett & Ker, 1990; Aerts et al. 1995) the fat pad and part of the calcaneus was removed from amputated test specimens. The present study tested whether this procedure influences the mechanical behaviour of the sample. Intact amputated feet were therefore mounted on steel rods driven th
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28. Stomatocyte–discocyte–echinocyte sequence of the human red blood cell: Evidence for the bilayer– couple hypothesis from membrane mechanics
Red-cell shape is encoded in the mechanical properties of the membrane. The plasma membrane contributes bending rigidity; the protein-based membrane skeleton contributes stretch and shear elasticity. When both effects are included, membrane mechanics can reproduce in detail the full stomatocyte–discocyte–echinocyte sequence by variation of a single param
National Academy of Sciences.
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29. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. The tissue-specific effects of lamin mutations are unclear, in part because the function of lamin A/C is incompletely defined, but the many muscle-specific phenotypes suggest t
American Society for Clinical Investigation.
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30. Texture, stress and age in the human femur.
The way in which remodelling of human bone is determined by the mechanics of life is explored in a neutron diffraction study of the femur. The hydroxyapatite crystals provide ability to resist vertical stress by a preferred alignment which is low at birth, increases to a maximum at an age of about three years and then falls away steadily in later life. This
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31. Chain folding and A:T pairing in human telomeric DNA: a model-building and molecular dynamics study.
The various types of chain folding and possible intraloop as well as interloop base pairing in human telomeric DNA containing d(TTAG3) repeats have been investigated by model-building, molecular mechanics, and molecular dynamics techniques. Model-building and molecular mechanics studies indicate that it is possible to build a variety of energetically favorab
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32. Influence of Lamin A on the Mechanical Properties of Amphibian Oocyte Nuclei Measured by Atomic Force Microscopy
The nuclear lamina is part of the nuclear envelope (NE). Lamin filaments provide the nucleus with mechanical stability and are involved in many nuclear activities. The functional importance of these proteins is highlighted by mutations in lamin genes, which cause a variety of human diseases (laminopathies). Here we describe a method that allows one to quanti
The Biophysical Society.
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33. A binding mechanism in protein–nucleotide interactions: Implication for U1A RNA binding
We present a close electronic view of the protein–base interface for the N-terminal domain of the human protein U1A. Combining accurate mixed quantum mechanics/molecular mechanics techniques and protein structure prediction methods, we provide a detailed electronic structure description of the protein–RNA stacking interactions. Our analysis indicates the
National Academy of Sciences.
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34. Rapamycin Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis
Transforming growth factor (TGF)-α is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human lung disease and animal models of pulmonary fibrosis. Overexpression of TGF-α in transgenic mice causes progressive and severe pulmonary fibrosis; however, the intracellular signaling pathw
American Thoracic Society.
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35. The shape of the Neandertal femur is primarily the consequence of a hyperpolar body form
Neandertal femora are distinct from contemporaneous near-modern human femora. Traditionally, these contrasts in femoral shape have been explained as the result of the elevated activity levels and limited cultural abilities of Neandertals. More recently, however, researchers have realized that many of these femoral differences may be explained by the cold
National Academy of Sciences.
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36. Human Haplotype Block Sizes Are Negatively Correlated With Recombination Rates
The International Haplotype Map (“HapMap”) Project is motivated, in part, by the belief that the organization of the human genome, the mechanics of recombination, and the population-level behavior of alleles at adjacent loci should allow researchers to parse the genome into small segments, or “blocks,” that show strong linkage disequilibrium (LD) bet
Cold Spring Harbor Laboratory Press.