Hnscc
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Oncologic Panendoscopy: Description of an Optimized Procedure Based on Our Experience
Abstract Introduction All patients with a new head and neck squamous cell carcinoma (HNSCC) undergo diagnostic panendoscopy as part of the screening for synchronous second primary tumors. It includes a pharyngolaryngoscopy (PLS), a tracheobronchoscopy and esophagoscopy, and a stomatoscopy. Rigid techniques are risky, with long learning curves. Objective We
International Archives of Otorhinolaryngology. Publicado em: 2022
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2. Comparison of Clinical Examination and Various Imaging Modalities in the Diagnosis of Head and Neck Cancer
Abstract Introduction Squamous cell Carcinoma of the Head and Neck (HNSCC) is the most common tumor entity of malignant processes in the head and neck area. Due to the metastasizing behavior of these tumors, the staging is indispensable for the treatment planning and requires imaging techniques, which are sensitive, specific, and as far as possible cost-eff
Int. Arch. Otorhinolaryngol.. Publicado em: 2021-04
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3. Mutational landscape of head and neck squamous cell carcinomas in a South Asian population
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigati
Genet. Mol. Biol.. Publicado em: 14/11/2019
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4. Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients. MATERIAL AND METHODS: Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgica
J. Appl. Oral Sci.. Publicado em: 2013-09
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5. Impact of HPV infection on the development of head and neck cancer
Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these
Braz J Med Biol Res. Publicado em: 15/03/2013
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6. p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma
CDKN2A encodes proteins such as p16 (INK4a), which negatively regulate the cell-cycle. Molecular genetic studies have revealed that deletions in CDKN2A occur frequently in cancer. Although p16 (INK4a) may be involved in tumor progression, the clinical impact and prognostic implications in head and neck squamous cell carcinoma (HNSCC) are controversial. The o
Braz J Med Biol Res. Publicado em: 2012-12
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7. Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer
The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR)
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-10
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8. Response of peripheral blood mononuclear cells to conditioned medium from cultured oral squamous cell carcinomas
The current study investigated the capacity for tumor factors secreted by head and neck squamous cell carcinoma (HNSCC) cell lines, KB, KB16, and HEP, to induce the secretion of various cytokines from peripheral blood mononuclear cells (PBMCs). PBMCs were isolated from blood samples collected from six healthy volunteers and these cells were incubated for 6,
Brazilian Oral Research. Publicado em: 2011-10
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9. Vimentin expression and the influence of Matrigel in cell lines of head and neck squamous cell carcinoma
Vimentin is a cytoeskeletal intermediate filament protein commonly observed in mesenchymal cells; however, it can also be found in malignant epithelial cells. It is demonstrated in several carcinomas, such as those of the cervix, breast and bladder, in which it is widely used as a marker of the epithelial to mesenchymal transition that takes place during emb
Brazilian Oral Research. Publicado em: 2011-06
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10. 5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer
The functional effect of the A>G transition at position 2756 on the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase), involved in folate metabolism, may be a risk factor for head and neck squamous cell carcinoma (HNSCC). The frequency of MTR A2756G (rs1805087) polymorphism was compared between HNSCC patients and individuals without history
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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11. Study of protein hnRNP K, SET and MARK3 as potential markers of prognosis in squamous cell cancer of head and neck (HNSCC). / Estudos das proteínas hnRNP K, SET e MARK3 como potenciais marcadores de prognóstico em câncer epidermóide de cabeça e pescoço (HNSCC)
The head and neck cancers constitute a major public health problem due to the high incidence and some types are associated with behavioral factors such as consumption of alcohol and tobacco. Despite these data, the disease, especially in its early stage can be cured and some types can be prevented. Therefore, there is a need to identify and validate new biom
Publicado em: 2009
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12. Osteopontina como marcador de resposta à radioterapia e quimioterapia em pacientes com câncer de cabeça e pescoço localmente avançado / Osteopontin as a marker of response to chemotherapy and radiotherapy in patients with locally advanced head and neck cancer
INTRODUCTION: Osteopontin (OPN) is a glycoprotein present in tissues and body fluids involved in several pathological processes that include inflammation, cell proliferation, invasion of the extracellular matrix, tumor progression and metastasis. In head and neck squamous cell carcinoma (HNSCC) patients, OPN has been associated with greater tumor aggressiven
Publicado em: 2008