Hmgr
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. Cloning and Characterization of the Gene Encoding 3-hydroxy-3- Methylglutaryl-coenzyme A (HMG-CoA) Reductase from Fritillaria Cirrhosa D. Don
ABSTRACT The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR; EC1.1.1.34) catalyzes the first committed step of isoprenoids biosynthesis in Mevalonate (MVA) pathway. Here we report for the first time the cloning and characterization of a full-length cDNA encoding HMGR from Fritillaria cirrhosa (FcHMGR), a bulbous medicinal plant. The full-length cDNA o
Braz. arch. biol. technol.. Publicado em: 29/11/2018
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2. Expressão de genes da via de biossíntese do Hormônio Juvenil em Melipona scutellaris (Hymenoptera, Apidae, Meliponini)
Em abelhas sem ferrão do gênero Melipona, nas quais a diferenciação de castas não depende somente da quantidade e/ou qualidade do alimento larval, o Hormônio Juvenil (HJ) tem sido apresentado como agente responsável, juntamente com fatores ambientais, por mecanismos genéticos que promovem as diferenças casta específicas. Na via de biossíntese do H
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/07/2011
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3. BioquÃmica quÃntica das estatinas, aspirina e anti-hipertensivos.
As doenÃas cardiovasculares (CVDs) compreendem um amplo espectro de doenÃas do coraÃÃo e vasos sanguÃneos (artÃrias e veias), entre as quais se incluem a doenÃa das artÃrias coronÃrias, o ataque cardÃaco, a angina, a sÃndrome coronariana aguda, o aneurisma da aorta, arritmias cardÃacas, a doenÃa cardÃaca congÃnita, a insuficiÃncia cardÃaca e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/04/2011
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4. Caracterização in silico e in vivo de genes das vias de biossíntese de isoprenóides em coffea spp
Os diterpenos cafestol e caveol, presentes na fração lipídica em grãos de café, originam-se da via de síntese de isoprenóides. Em vegetais superiores, duas vias localizadas em compartimentos intracelulares separados estão envolvidas na biossíntese de isopentenil difosfato (IPP) e do isômero dimetilalil difosfato (DMAPP). No citosol IPP é derivado
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/04/2007
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5. Differential activation of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes by wounding and pathogen challenge.
Potato genes encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) were expressed in response to pathogen, elicitor, and wounding. HMGR catalyzes the rate-limiting step in isoprenoid biosynthesis leading to accumulation of phytoalexins and steroid glycoalkaloids. Wounding caused increases in HMGR mRNA levels. A rapid and transient peak occurred 30
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6. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is controlled through synthesis, degradation and phosphorylation to maintain the concentration of mevalonate-derived products. In addition to the physiological regulation of HMGR, the h
Oxford University Press.
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7. Subcellular Localization of Arabidopsis 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase1
Plants produce diverse isoprenoids, which are synthesized in plastids, mitochondria, endoplasmic reticulum (ER), and the nonorganellar cytoplasm. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the synthesis of mevalonate, a rate-limiting step in the cytoplasmic pathway. Several branches of the pathway lead to the synthesis of structurally a
American Society of Plant Biologists.
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8. 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in the Endosperm of Maize vivipary Mutants.
During seed maturation the levels of the rate-limiting enzyme of isoprenoid biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) decrease while the levels of the isoprenoid compund abscisic acid (ABA) increase. In the present study, we demonstrate that HMGR specific activity is inversely correlated with endogenous ABA levels in Zea mays endos
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9. Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme.
The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR; EC 1.1.1.34) catalyzes the first rate-limiting step in plant isoprenoid biosynthesis. Arabidopsis thaliana contains two genes, HMG1 and HMG2, that encode HMGR. We have cloned these two genes and analyzed their structure and expression. HMG1 and HMG2 consist of four exons and three small introns that
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10. Is the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase a Rate-Limiting Step for Isoprenoid Biosynthesis in Plants?
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the irreversible conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate and is considered a key regulatory step controlling isoprenoid metabolism in mammals and fungi. The rate-limiting nature of this enzyme for isoprenoid biosynthesis in plants remains controversial. To investigate
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11. Targeting and topology in the membrane of plant 3-hydroxy-3-methylglutaryl coenzyme A reductase.
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the synthesis of mevalonate. This is the first committed step of isoprenoid biosynthesis. A common feature of all known plant HMGR isoforms is the presence of two highly conserved hydrophobic sequences in the N-terminal quarter of the protein. Using an in vitro system, we showed that
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12. Characterization of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity during Maize Seed Development, Germination, and Seedling Emergence.
Many isoprenoid compounds are necessary for growth and development of the seed and seedling. The first committed step in the biosynthesis of isoprenoid compounds is the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate. This study shows that the specific activity of the rate-limiting enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HM