Hla Antigens
Mostrando 13-24 de 726 artigos, teses e dissertações.
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13. Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal
Silent transmission of Mycobacterium leprae, as evidenced by stable leprosy incidence rates in various countries, remains a health challenge despite the implementation of multidrug therapy worldwide. Therefore, the development of tools for the early diagnosis of M. leprae infection should be emphasised in leprosy research. As part of the continuing effort to
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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14. Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome
OBJECTIVE: This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients. METHODS: Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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15. BCR-ABL rearrangement and HLA antigens: a possible link to leukemia pathogenesis and immunotherapy
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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16. Enterovirus infections and type 1 diabetes mellitus: is there any relationship?
Several health organizations have classified diabetes mellitus, a metabolic syndrome, as the epidemic of the century, since it affects millions of people worldwide and is one of the top ten causes of death. Type 1 diabetes is considered to be an autoimmune disease, in which autoaggressive T cells infiltrate the islets of Langerhans in the pancreas, leading t
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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17. Freqüências de alelos e haplótipos HLA A, -B e DRB1 em uma amostra de doadores voluntários de medula óssea do estado do Rio Grande do Sul
As moléculas HLA (Human Leucocyte Antigens) são proteínas codificadas por genes altamente polimórficos localizados na região do MHC (Major Histocompatibility Complex) no braço curto do cromossomo 6 humano. Elas estão envolvidas em processos de resposta imunológica, sendo responsáveis pela apresentação de antígenos aos linfócitos T. O sistema HLA
Publicado em: 2011
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18. Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the s
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
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19. Análise da imunogenicidade de uma vacina de DNA codificando epitopos CD4 promíscuos e conservados do HIV-1 em camundongos BALB/c e transgênicos para moléculas de HLA classe II / Immunogenicity analysis of a DNA vaccine encoding promiscuous and conserved HIV-1 CD4 epitopes in BALB/c and HLA class II transgenic mice
Abordagens atuais no desenho de vacinas contra o HIV-1 estão focadas em imunógenos que codificam proteínas inteiras do HIV-1 e visam induzir respostas citotóxicas específicas. É concebível que vacinas bem-sucedidas devem induzir respostas contra múltiplos epitopos do HIV-1, coincidindo com seqüências das cepas circulantes do vírus, conhecido por s
Publicado em: 2010
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20. Transfusão de plaquetas: do empirismo ao embasamento científico
Despite major advances in Brazilian blood transfusion therapy with a growing number of scientific publications, an increased number of repeat donors and a decline in serological ineligibility, a lack of conformity in the application of pre-transfusion tests that may compromise transfusion safety is still observed at transfusion agencies in the fringes of the
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2010
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21. Predição In Silico de Epítopos de Microrganismos com Identidade a Autoantígenos Humanos / In Silico Prediction of Microorganism Motifs with Identity to Human Autoantigens
The origin of autoimmune diseases is multifactorial. It involves environmental conditions and genetic predisposition that difficulties its identification. Several researchers have studied the association between infectious agents and autoimmunity, which can be initiated by a process named molecular mimicry. In this case, cross immune responses involving self
Publicado em: 2010
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22. Extração de DNA a partir de sangue humano coagulado para aplicação nas técnicas de genotipagem de antígenos leucocitários humanos e de receptores semelhantes à imunoglobulina
O objetivo deste estudo foi padronizar uma metodologia de extração de DNA de alta qualidade a partir de amostras de sangue coagulado. Quarenta e oito amostras de sangue humano coagulado foram utilizadas para a extração de DNA pelo kit comercial EZ-DNA® (Biological Industries, Beit Haemek, Israel), pelo kit de coluna Neoscience® (One Lambda Inc., San Di
Revista da Sociedade Brasileira de Medicina Tropical. Publicado em: 2009-12
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23. Artrite reumatoide em Afro-brasileiros : "O papel do HLA" / Rheumatoid arthritis in Afro-brazilians : "The role of HLA"
The association of histocompatibility antigens with Rheumatoid Arthritis (RA) comes being demonstrated in innumerable studies. However, the evaluation in afrodescendents populations still little was studied. The aim of this study has been to determine the frequency of HLA-DRB1 alleles, and the contributions of the polymorphism of these alleles in the suscept
Publicado em: 2009
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24. Alleles HLA-DR in patients with polyarteritis nodosa and microscopic polyangiitis / Alelos HLA-DR em pacientes com poliarterite nodosa e poliangite microscopica
The aim of this study was to evaluate the frequency and clinical associations of HLA-DR alleles in Brazilian Caucasian patients with polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA). We evaluated 29 Caucasian patients with vasculitis classified as PAN or MPA according to the American College of Rheumatology (ACR) 1990 Criteria and Chapel Hill Con
Publicado em: 2009