Heterocyclic Compounds
Mostrando 1-12 de 104 artigos, teses e dissertações.
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1. Synthesis of Hydroxybenzodiazepines with Potential Antioxidant and Antifungal Action
Benzodiazepines derivatives are nitrogen heterocyclic compounds that have various industrial, synthetic, and medicinal applications. Therefore, its potential fully justifies every effort towards the improvement of new, selective, and competent production of these heterocyclic compounds. The novelty of this study encompasses the synthesis of new hydroxylated
J. Braz. Chem. Soc.. Publicado em: 2021-03
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2. HUISGEN AND HIS ADVENTURES IN A PLAYGROUND OF MECHANISMS AND NOVEL REACTIONS
The death of professor Rolf Huisgen (1920-2020) was announced on March 26th 2020, in the midst of the COVID-19 pandemic. Professor Huisgen was professor emeritus at the University of Munich in Germany, and studied in detail the mechanism of the 1,3-dipolar cycloaddition reaction, significantly expanding its scope. Even though he did not discover this reactio
Quím. Nova. Publicado em: 2021-02
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3. The effects of adding garlic (Allium sativum L.) on the volatile composition and quality properties of yogurt
Abstract In this study, the effects of adding garlic (Allium sativum L.) of different origins on the volatile composition and quality properties of yogurt were investigated on day 1, 7 and 14 of storage. The addition of garlic did not cause a decrease in the total specific microorganism count (>107) in yogurt samples, and it led to a significant decrease in
Food Sci. Technol. Publicado em: 2020-12
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4. COMPOSTOS QUIMIOTERÁPICOS DE OURO: UMA VISÃO GERAL DOS COMPLEXOS ANTICÂNCER DE Au(I/III) EM RELAÇÃO À ESTRUTURA DO LIGANTE
Gold compounds engage an important place in the field of medicinal chemistry due to their therapeutic properties. Since the last four decades, Au(I) and Au(III) complexes have attracted the attention of researchers due to their anti-tumor proprieties and the different mechanisms of action they display in comparison to conventional anticancer platinum compoun
Quím. Nova. Publicado em: 2020-09
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5. New Synthetic Quinolines as Cathepsin K Inhibitors
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis. Quinolines are an important class of heterocyclic molecular leads with a great pharmacological potential and represent a relevant sca
J. Braz. Chem. Soc.. Publicado em: 2020-08
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6. Design, Synthesis and Antitubercular Activity of Novel Isoniazid-Cyclic-Amine-Azachalcones Hybrids
In this work, it is described the design of twenty-four heterocyclic amine-azachalcones compounds through molecular hybridization of chalcone scaffold and fragments of isoniazid, fluoroquinolones, and linezolid with antituberculosis potential. The new compounds were synthesized via Claisen-Schmidt condensation, providing yields of 36-95%. Fifteen compounds s
J. Braz. Chem. Soc.. Publicado em: 2020-06
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7. DFT Study of the Interaction between the Ni2+ and Zn2+ Metal Cations and the 1,2-Dithiolene Ligands: Electronic, Geometric and Energetic Analysis
Density functional theory (DFT) (B3LYP/6-311++G(d,p)) calculations of the interacting strength 1,2-dithiolene anionic ligands with the [M(OH2)4]2+ and [M(OH2)2]2+ complexes (M = Ni and Zn) were performed. Three series of ligands were studied: compounds with an aromatic ring, with an ethylene moiety and with a heterocyclic ring. The ligands have substituents
J. Braz. Chem. Soc.. Publicado em: 23/05/2019
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8. Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes
Abstract Background: Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required. Nitro-heterocyclic derivatives have been used a
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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9. Synthesis, Antimicrobial Activity and Structure-Activity Relationship of Some 5-Arylidene-thiazolidine-2,4-dione Derivatives
Derivatives of the thiazolidine-2,4-dione core represent a heterocyclic class with several correlated properties. In this context, the synthesis of structural analogues of these bioactive substances becomes attractive in the field of medicinal chemistry. These analogues act as antimicrobial agents against Gram-positives pathogens. The present work aimed to s
J. Braz. Chem. Soc.. Publicado em: 2019-01
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10. Trichoderma harzianum MTCC 5179 impacts the population and functional dynamics of microbial community in the rhizosphere of black pepper (Piper nigrum L.)
Abstract Employing Illumina Hiseq whole genome metagenome sequencing approach, we studied the impact of Trichoderma harzianum on altering the microbial community and its functional dynamics in the rhizhosphere soil of black pepper (Piper nigrum L.). The metagenomic datasets from the rhizosphere with (treatment) and without (control) T. harzianum inoculation
Braz. J. Microbiol.. Publicado em: 2018-09
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11. Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds
BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search for new, effective and safe antimalarial drugs is crucial. Heterocyclic compounds, such as dihydropyrimidinone
Mem. Inst. Oswaldo Cruz. Publicado em: 18/06/2018
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12. INOVAÇÃO E PROPRIEDADE INTELECTUAL DOS 1,2,4-OXADIAZÓIS: UMA PROSPECÇÃO TECNOLÓGICA FUNDAMENTADA EM BASE DE DADOS DE PATENTES E PERIÓDICOS
1,2,4-Oxadiazoles are heterocyclic compounds that have a remarkable range of applications. This overview focused on investigating the potential and scientific and technological evolution of these compounds through an analysis of patent databases and scientific papers. Prospecting technology using patent databases is an important tool for mapping technologies
Quím. Nova. Publicado em: 2018-06