Hepatocellular Carcinoma Therapy
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Chlorophyll treatment combined with photostimulation increases glycolysis and decreases oxidative stress in the liver of type 1 diabetic rats
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditions such as T1DM, changes in liver metabolic pathways re
Braz J Med Biol Res. Publicado em: 2020-01
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2. Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed to investigate the antiproliferative and anti-invasive effects of urolithin A in a stable full-length HBV gene integrated cell li
Braz J Med Biol Res. Publicado em: 07/05/2018
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3. Survival benefits of interferon-based therapy in patients with recurrent hepatitis C after orthotopic liver transplantation
Recurrent hepatitis C after orthotopic liver transplantation (OLT) is universal and can lead to graft failure and, consequently, reduced survival. Hepatitis C treatment can be used to prevent these detrimental outcomes. The aim of this study was to describe rates of hepatitis C recurrence and sustained virological response (SVR) to interferon-based treatment
Braz J Med Biol Res. Publicado em: 09/01/2017
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4. Treatment of hepatitis C virus genotype 3 infection with direct-acting antiviral agents
Hepatitis C virus (HCV) genotype 3 is responsible for 30.1% of chronic hepatitis C infection cases worldwide. In the era of direct-acting antivirals, these patients have become one of the most challenging to treat, due to fewer effective drug options, higher risk of developing cirrhosis and hepatocellular carcinoma and lower sustained virological response (S
Braz J Med Biol Res. Publicado em: 24/10/2016
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5. Clinical and pathological evaluation of fibrolamellar hepatocellular carcinoma: a single center study of 21 cases
OBJECTIVES: Fibrolamellar hepatocellular carcinoma is a rare primary malignant liver tumor that differs from conventional hepatocellular carcinoma in several aspects. The aim of this study was to describe the clinical, surgical and histopathological features of fibrolamellar hepatocellular carcinoma and to analyze the factors associated with survival. METHO
Clinics. Publicado em: 2015-03
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6. Synergistic growth inhibition by sorafenib and vitamin K2 in human hepatocellular carcinoma cells
OBJECTIVE: Sorafenib is an oral multikinase inhibitor that has been proven effective as a single-agent therapy in hepatocellular carcinoma, and there is a strong rationale for investigating its use in combination with other agents. Vitamin K2 is nearly non-toxic to humans and has been shown to inhibit the growth of hepatocellular carcinoma. In this study, we
Clinics. Publicado em: 2012-09
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7. Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer
A dendritic cell (DC)-based vaccine strategy could reduce the risk of recurrence and improve the survival of breast cancer patients. However, while therapy-induced apoptosis of hepatocellular and colorectal carcinoma cells can enhance maturation and antigen presentation of DCs, whether this effect occurs in breast cancer is currently unknown. In the present
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06
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8. Response predictors to treatment with pegylated interferon in chronic hepatitis B
The clinical and epidemiological importance of chronic B hepatitis is currently unquestionable as a cause of end-stage liver disease and hepatocellular carcinoma. Recently, predictors of treatment response of this disease have been studied, both before and during the course of medication. Therapy stopping rules have been proposed, which may be useful in pati
Brazilian Journal of Infectious Diseases. Publicado em: 2010-10
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9. Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
OBJECTIVES: We performed a national survey to update hepatocellular carcinoma (HCC) epidemiology in Brazil and determined the clinical and epidemiological profiles of patients with HCC in different Brazilian regions. METHODS: Data from 29 centers included 1,405 patients diagnosed with HCC from 2004 to 2009. RESULTS: The median age was 59 (1-92 years old; 78%
Clinics. Publicado em: 2010
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10. Modelo matemático de distribuição larga de dose limiar em tumores submetidos a múltiplas sessões de terapia fotodinâmica / Mathematical model for broad distribution of threshold dose in tumors treated with multiple photodynamic therapy sessions
Photodynamic therapy is a well known treatment option for many types of malignant and nonmalignant lesions. This technique causes cell damage through a photochemical reaction, generating oxidative agents responsible for tumor cell killing. In several cases, multiple PDT-sessions are needed to promote cancer eradication. However, several clinical studies have
Publicado em: 2010
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11. Avaliação da injeção percutânea de etanol como tratamento primário para carcinoma hepatocelular em cirróticos / Evaluation of percutaneous ethanol injection as first-line therapy for hepatocellular carcinoma in cirrhotic patients
Introdução: A injeção percutânea de etanol (PEI) é um método de ablação local considerado curativo para carcinomas hepatocelulares (CHC) pequenos. Não há dados sobre PEI para tratamento do CHC na América Latina. Pacientes e métodos: Incluídos 100 pacientes cirróticos submetidos à PEI como terapia primária para o CHC no Serviço de Gastroente
Publicado em: 2009
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12. Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review
Hepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C exp
Brazilian Journal of Infectious Diseases. Publicado em: 2008-04