Heme
Mostrando 13-24 de 1732 artigos, teses e dissertações.
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13. Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats
Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of hemorrhage/resuscitation (HS) and subsequent endotoxemia. E
Braz J Med Biol Res. Publicado em: 25/02/2019
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14. Avaliação da zinco protoporfirina (ZPP) em ruminantes domésticos
RESUMO Nos sistemas de criação de ruminantes, a anemia crônica pode levar a grandes prejuízos econômicos, sendo decorrente da deficiência de ferro no organismo. Quando este se torna indisponível para ser incorporado à hemoglobina, forma-se um composto denominado zinco protoporfirina (ZPP), que pode ser um marcador precoce para a anemia, útil, portan
Arq. Bras. Med. Vet. Zootec.. Publicado em: 2018-08
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15. The role of ClpX in erythropoietic protoporphyria
ABSTRACT Hemoglobin is an essential biological component of human physiology and its production in red blood cells relies upon proper biosynthesis of heme and globin protein. Disruption in the synthesis of these precursors accounts for a number of human blood disorders found in patients. Mutations in genes encoding heme biosynthesis enzymes are associated wi
Hematol., Transfus. Cell Ther.. Publicado em: 2018-06
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16. Subprodutos do metabolismo da hemoglobina se associam com resposta inflamatória em pacientes com acidente vascular cerebral hemorrágico
RESUMO Objetivo: Avaliar o relacionamento entre os níveis cerebrais de ferro e heme e a resposta inflamatória sistêmica e no sistema nervoso central, assim como o papel dos sistemas de defesa contra a toxicidade do ferro e do heme, no sistema nervoso central. Métodos: Avaliamos uma coorte prospectiva de pacientes com quadro de hemorragia intracraniana
Rev. bras. ter. intensiva. Publicado em: 15/03/2018
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17. Effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid-induced acute lung injury in rats
Abstract Purpose: To investigate the effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid -induced acute lung injury in rats. Methods: A total of 32 male Sprague-Dawley rats (250-300g) were randomly divided into the following four groups (n=8/group): group C, group OA, group OA+PR, and group OA+IX to compare r
Acta Cir. Bras.. Publicado em: 2018-03
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18. The use of aromatase inhibitors in boys with short stature: what to know before prescribing?
ABSTRACT Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to imp
Arch. Endocrinol. Metab.. Publicado em: 2017-08
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19. Liver Damage Induced by Succinylacetone: A Shared Redox Imbalance Mechanism between Tyrosinemia and Hepatic Porphyrias
To show liver failure mediated by 5-aminolevulinic acid (ALA), a heme precursor accumulated in inborn and acquired porphyrias, rats were treated with succinylacetone methyl ester (SAME). Treated rats underwent the expected ALA accumulation in plasma, liver and urine as a result from inhibition of ALA dehydratase (ALAD) activity. The enzyme activity decreased
J. Braz. Chem. Soc.. Publicado em: 2017-07
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20. Effects of heme oxygenase-1 recombinant Lactococcus lactis on the intestinal barrier of hemorrhagic shock rats
This study aimed to investigate the effects of heme oxygenase-1 recombinant Lactococcus lactis (LL-HO-1) on the intestinal barrier of rats with hemorrhagic shock. One hundred Sprague-Dawley male rats (280–320 g) were randomly divided into healthy control group (N group) and hemorrhagic shock group (H group). Each group was subdivided into HO1t, HO2t, HO3t,
Braz J Med Biol Res. Publicado em: 05/06/2017
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21. Iron restriction increases myoglobin gene and protein expression in Soleus muscle of rats
ABSTRACT Iron is an important trace element for proper cell functioning. It is present in cytochromes, hemoglobin and myoglobin (Mb), where it binds to oxygen. It is also an electron acceptor in the respiratory chain. Mb is an 18 kDa heme-protein, highly expressed in skeletal muscle and heart. The expression of several genes involved in the metabolism of iro
An. Acad. Bras. Ciênc.. Publicado em: 2016-12
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22. Prevalência e fatores de risco da anemia em crianças,
Resumo Objetivo: Identificar a prevalência e os fatores associados à anemia em crianças que frequentam berçários de Centros Municipais de Educação Infantil (CMEI) de Colombo (PR). Métodos: Estudo analítico, de caráter transversal, com amostra representativa de 334 crianças obtida por amostragem estratificada por conglomerados, com seleção alea
J. Pediatr. (Rio J.). Publicado em: 2016-08
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23. Priming previne a insuficiência renal aguda nefrotóxica através da estimulação do mecanismo de defesa antioxidante
RESUMO Introdução: Priming é um mecanismo de proteção induzida pela exposição anterior de uma célula ou órgão a baixas ou mesmas concentrações de uma substância tóxica. Objetivo: analisar o mecanismo de priming induzido pela exposição a gentamicina em células tubulares proximais humanas e na insuficiência renal aguda (IRA). Métodos: Cé
J. Bras. Nefrol.. Publicado em: 2016-06
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24. Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats
The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC). In the central nervous system, the locus coeruleus (LC) is known to be a region that expresses the heme oxygenase enzyme (HO
Braz J Med Biol Res. Publicado em: 08/04/2016