Helicobacter Pylori Drug Effects
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Gastroesphageal reflux disease : influence of cagA strains of Helicobacter pylori in the proton pump inhibition therapeutic response in patients with low grade erosive esophagitis / "Doença do refluxo gastroesofágico: influência da cepa cagA do Helicobacter pylori na resposta terapêutica à inibição da bomba protônica em pacientes com esofagite erosiva leve"
Eighty three patients with grade I-II of the modified Savary-Miller classification have been studied. They were divided in three groups. One without Helicobacter pylori infection, two with the bacterium, one with and other without the cagA gene. We verified the influence of cagA status, histopathology of antrum and body of the stomach and gastrinemia in the
Publicado em: 2006
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2. Estudo da influencia da acidez gastrica na farmacocinetica da furazolidona : implicações terapeuticas para a erradicação do Helicobacter pylori
Background: The administration of omeprazole may interfere with the absorption of orally administered drugs by reducing gastric pH and thus tablets dissolution.The aim of this study was to investigate the effects of a tive day administration of omeprazole on furazolidone pharmacokinetics. Methods: Eighteen healthy (male, female) volunteers were selected. The
Publicado em: 2001
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3. Effects of Metronidazole, Tetracycline, and Bismuth-Metronidazole-Tetracycline Triple Therapy in the Helicobacter pylori SS1 Mouse Model after 1 Day of Dosing: Development of an H. pylori Lead Selection Model
We evaluated the effect of optimized doses and dosing schedules of metronidazole, tetracycline, and bismuth-metronidazole-tetracycline (BMT) triple therapy with only 1 day of dosing on Helicobacter pylori SS1 titers in a mouse model. A reduction of bacterial titers was observable with 22.5 and 112.5 mg of metronidazole per kg of body weight (as well as BMT)
American Society for Microbiology.
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4. A Novel Action of the Proton Pump Inhibitor Rabeprazole and Its Thioether Derivative against the Motility of Helicobacter pylori
The motility of Helicobacter pylori was maximum at 37°C and at pH 6. A newly developed proton pump inhibitor, rabeprazole (RPZ), and its thioether derivative (RPZ-TH) markedly inhibited the motility of H. pylori. The concentrations of the drug necessary to inhibit 50% of the motility were 0.25, 16, 16, and >64 μg/ml for RPZ-TH, RPZ, lansoprazole, and omepr
American Society for Microbiology.
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5. Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model
The purpose of the present study was to design mucoadhesive gliadin nanoparticles (GNP) containing amoxicillin and to evaluate their effectiveness in eradicating Helicobacter pylori. GNP-bearing amoxicillin (AGNP) was prepared by desolvation method. The effect of process variables such as gliadin concentration and initial drug loading on particle size, shape
Springer-Verlag.
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6. Pharmacodynamic Effects of Nitroimidazoles Alone and in Combination with Clarithromycin on Helicobacter pylori
Pharmacodynamic studies of Helicobacter pylori exposed to metronidazole and tinidazole alone and in combination with clarithromycin were performed by bioluminescence assay of intracellular ATP. The pharmacodynamic parameter control-related effective regrowth time (CERT) was used. CERT is defined as the time required for the resumption of logarithmic growth a
American Society for Microbiology.
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7. Nitazoxanide in Treatment of Helicobacter pylori: a Clinical and In Vitro Study
Nitazoxanide (NTZ) is an antibiotic with microbiological characteristics similar to those of metronidazole but without an apparent problem of resistance. The aim of this study was the prospective evaluation of NTZ given as a single agent in the treatment of Helicobacter pylori infection. Twenty culture-positive patients with dyspepsia who had previously fail
American Society for Microbiology.
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8. Nitazoxanide, a Potential Drug for Eradication of Helicobacter pylori with No Cross-Resistance to Metronidazole
Nitazoxanide, a thiazolide compound, and its desacetyl derivative, tizoxanide, have antimicrobial properties against anaerobic bacteria, as well as against helminths and protozoa. Because the treatment of Helicobacter pylori infection may be jeopardized by metronidazole resistance, nitazoxanide and tizoxanide were tested in vitro against these bacteria. The
American Society for Microbiology.
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9. Effects of Lansoprazole and Amoxicillin on Uptake of [14C]Clarithromycin into Gastric Tissue in Rats
Triple therapy consisting of clarithromycin (CLR), lansoprazole (LPZ), and amoxicillin (AMZ) is effective as eradication therapy for patients with peptic ulcer disease and Helicobacter pylori infection. We evaluated the effects of LPZ and AMZ on the uptake of [14C]CLR into the gastric tissue of rats. After administration of [14C]CLR alone or in combination w
American Society for Microbiology.
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10. Multiple-Dose Safety and Pharmacokinetics of Oral Garenoxacin in Healthy Subjects
Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes. This study was conducted to evaluate the safety and tolerability of multiple oral doses (100 to 1,200 mg/day) of garenoxacin in h
American Society for Microbiology.