H3 Antihistamine
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. A quantum chemical study on a set of H3 antihistamine molecules / Aplicação da química quântica ao estudo de um grupo de moléculas antihistamínicas H3
Nesta tese foi estudado um grupo de 28 compostos não-imidazólicos antagonistas do receptor H3 através de cálculos de orbitais moleculares utilizando os métodos de química quântica Austin Model 1, Hartree-Fock-Roothaan e Teoria do Funcional da Densidade com o objetivo de investigar possíveis relações entre descritores eletrônicos teóricos e as afi
Publicado em: 2010
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2. DEVELOPMENT AND VALIDATION OF METHODOLOGY FOR THE EVALUATION OF RUPATADINE BY LIQUID CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS / DESENVOLVIMENTO E VALIDAÇÃO DE METODOLOGIA PARA AVALIAÇÃO DE RUPATADINA POR CROMATOGRAFIA LÍQUIDA E ELETROFORESE CAPILAR
Rupatadine is a second generation antihistamine H1, from the pyperidinic group, which inhibits both the histamine and platelet activating factor effects, and is clinically used for the treatment of allergic rhinitis and chronic urticaria. The methods for the evaluation of rupatadine in pharmaceutical products were developed and validated in the present work.
Publicado em: 2009
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3. Estudo do papel da angiotensina II na amplificação do edema de pata induzido por carragenina ou dextran em ratos / Study of the paper of the angiotensin II in the amplification of edema of induced leg for carrageenan or dextran in rats
Angiotensin II (Ang II) exerts its actions via AT1 and AT2 receptors. Recent studies have demonstrated that the renin-angiotensin system (RAS) participates in inflammation. The aim of this study was to evaluate the effect of Ang II on models of acute inflammation. Wistar rats were separated in the groups: saline (Sal), Ang II (1g), losartan (LOS, AT1 antagon
Publicado em: 2005
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4. Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.
The antihistamine [3H]mepyramine binds to H1 histamine receptors in mammalian brain membranes. Potencies of H1 antihistamines at the binding sites correlate with their pharmacological antihistamine effects in the guinea pig ileum. Specific [3H]mepyramine binding is saturable with a dissociation constant of about 4 nM in both equilibrium and kinetic experimen
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5. A unitary mechanism of calcium antagonist drug action.
[3H]Nitrendipine binding to drug receptor sites associated with calcium channels is allosterically regulated by a diverse group of calcium channel antagonists. Verapamil, D-600 (methoxyverapamil), tiapamil, lidoflazine, flunarizine, cinnarizine, and prenylamine all reduce [3H]nitrendipine binding affinity. By contrast, diltiazem, a benzothiazepine calcium ch
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6. Effect of azelastine on bronchoconstriction induced by histamine and leukotriene C4 in patients with extrinsic asthma.
Azelastine, a new oral agent with antiallergic and antihistamine properties, has been shown to inhibit the effect of histamine and leukotriene (LT) in vitro, though not a specific leukotriene receptor antagonist. The effect of both a single dose (8.8 mg) and 14 days' treatment (8.8 mg twice daily) with azelastine on bronchoconstriction induced by LTC4 and hi
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7. Studies of human C5a as a mediator of inflammation in normal human skin.
C5a is an 11,000-D fragment of the fifth component of complement (C5) with potent anaphylatoxic and leukocyte chemotactic activities. C5a is believed to play an important role in the pathophysiology of certain skin disorders and systemic diseases with cutaneous manifestations. However, there is very little known about the in vivo reactivity of C5a in man. In