Guanylin
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones
The isolation of heat-stable enterotoxin (STa) from Escherichia coli and cholera toxin from Vibrio cholerae has increased our knowledge of specific mechanisms of action that could be used as pharmacological tools to understand the guanylyl cyclase-C and the adenylyl cyclase enzymatic systems. These discoveries have also been instrumental in increasing our un
Braz J Med Biol Res. Publicado em: 03/03/2014
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2. Estudo dos efeitos da alta ingestÃo de cloreto de sÃdio por via oral sobre o metabolismo diÃrio e funÃÃo renal de ratos. / Study of effects on the daily metabolism and the renal function of rats under high oral ingestion of sodium chloride.
Guanylin (GN), uroguanylin (UGN), and the bacterial heat-stable enterotoxin (ST) peptides comprise a new family of cyclic guanosine 3â-5â monophosphate (cGMP)-regulating agonist. Ingestion of a salt meal induces secretion of GN and UGN into the intestinal lumen, where they inhibit Na+ absorption and induces Cl-, HCO3- , and water secretion. Simultaneously,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/01/2009
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3. Efeito da uroguanilina sobre o transporte de hidrogênio em túbulos renais de rins de rato e em linhagens de células proximais e distrais / Effect of Uroguanylin on hydrogen transport in rat renal tubules and in proximal and distal cells lines
Uroguanilina (UGN) é um peptídeo normalmente sintetizado no intestino que modula o balanço de sódio através de ações renais. Investigamos os efeitos e os mecanismos de sinalização envolvidos na ação da UGN sobre a secreção de H+, em túbulos renais de ratos e em células LLC-PK1 (proximais) e MDCK-C11 (distais). Nos estudos in vivo foi utilizada
Publicado em: 2009
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4. AÃÃes farmacolÃgicas da ser-thr-lys-guanilina em sistema de perfusÃo de rim isolado de rato / Pharmacological actions of ser-thr-lys-guanilina in isolated perfused rat kidney
Guanylin and uroguanylin are members of a family of peptides that stimulates cGMP production in several organic tissues, as intestine, kidney, airway, linfonodes, testis, brain and adrenal medulla (Field et a.l., 1978; Forte et al., 1988, 1989; Hamra et al., 1993; Schulz et al., 1992). Their 15 amino acid structures have been identified from rat intestine an
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2005
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5. Eletrophysiological evaluation of guanylin and urogunylin in rat brain / Avaliação eletrofisiológica da ação da guanilina e de uroguanilina em cérebro de ratos
Os peptídeos termo-estáveis guanilina e uroguanilina foram inicialmente isolados e identificados do intestino de rato e de urina de opossum: suas propriedades são atribuídas ao controle do transporte de sal e água no rim e intestino, mediado pelo GMPc. O presente estudo propõe-se a avaliar a atividade neurofisiológica dos peptídeos do tipo guanilina,
Publicado em: 2003
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6. Guanylin stimulation of Cl- secretion in human intestinal T84 cells via cyclic guanosine monophosphate.
Intestinal salt and fluid secretion is stimulated by Escherichia coli heat-stable enterotoxins (ST) through activation of a membrane guanylate cyclase found in the intestine. Guanylin is an endogenous intestinal peptide that has structural similarity to the bacterial peptides. Synthetic preparations of guanylin or E. coli ST 5-17 stimulated Cl- secretion in
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7. The Escherichia coli heat-stable enterotoxin is a long-lived superagonist of guanylin.
The mechanism by which bacterial heat-stable enterotoxins (ST I STA) cause diarrhea in humans and animals has been linked to the activation of an intestinal membrane-bound guanylate cyclase. Guanylin, a recently discovered rat intestinal peptide, is homologous in structure to ST I and can activate guanylate cyclase present on the human colonic carcinoma cell
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8. Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide.
Guanylin, a bioactive peptide, has recently been isolated from the intestine; this peptide activates intestinal guanylate cyclase (i.e., guanylate cyclase C) and thus is potentially involved in the regulation of water/electrolyte transport in the gastrointestinal mucosa. As yet, the cells involved in synthesis, storage, or secretion of guanylin have not been
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9. Bronchiolar nonciliated secretory (Clara) cells: source of guanylin in the mammalian lung.
The peptide guanylin, which has recently been isolated from the intestine, is involved in the regulation of fluid secretion in the intestinal epithelium by activation of guanylate cyclase C, the putative guanylin receptor. Since the latter protein is also expressed in airway epithelia, we investigated the lung of three mammalian species for the presence and
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10. Expression of guanylin in “pars tuberalis-specific cells” and gonadotrophs of rat adenohypophysis‖
The intestinal peptide guanylin regulates the electrolyte/water transport in the gastrointestinal epithelium by paracrine/luminocrine mechanisms. Because guanylin also circulates in the blood, we investigated the rat hypothalamo-pituitary region for expression and cellular localization of this peptide. Reverse transcriptase–PCR analyses with guanylin-speci
The National Academy of Sciences.
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11. Segmental differences in the effects of guanylin and Escherichia coli heat-stable enterotoxin on Cl- secretion in human gut.
1. Mucosally added synthetic guanylin and Escherichia coli heat-stable enterotoxin (STa) increased short-circuit current (ISC) across isolated muscle-stripped human intestine in vitro. 2. Serosal bumetanide inhibited ISC responses indicating that guanylin and STa stimulate electrogenic chloride secretion. 3. ISC responses were markedly greater in the colon t
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12. Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.
The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate the human intestinal T84 cell guanylate cyclase have been purified from urine and intestinal mucosa of opossums (Didelphis virginiana). The highly acidic peptid