Gtp Model
Mostrando 1-12 de 193 artigos, teses e dissertações.
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1. PREDNISONA E MELOXICAM NO TRATAMENTO DE RATOS SUBMETIDOS AO TRAUMA AGUDO DA MEDULA ESPINHAL / Prednisone and meloxicam in the treatment of rats submitted to compressive spinal cord injury
Considering the relevance of study of traumatic spinal cord injury in humans and animals, the aim of the study was investigated the use of the prednisone and meloxicam in treatment of rats submitted the experimental model of acute spinal cord injury with 2Fr Fogarty catheter with evaluation of oxidative stress, Neurological tests and histological exam. Ninet
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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2. Geossistema, território e paisagem : o caso da Reserva Biológica de Sooretama
Esta dissertação tem como proposta investigar, por meio do estudo integrado da paisagem apoiada na interface das relações entre a sociedade e a natureza, o estudo de caso da Reserva Biológica de Sooretama localizada no Município de Sooretama, Estado do Espírito Santo Brasil. Sob essa abordagem integrada foi analisada a evolução da paisagem e o proce
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2011
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3. Caracterização funcional e estrutural das septinas humanas 1, 6 e 8 / Functional and structural characterization of human septins 1, 6 and 8
Septins have a central domain which binds GTP (GTPase domain) and two other variable domains at their N- and C-termim Their principal characteristic is the ability to bind to other septins, thereby forming filaments. This is intimately related to their functions in cytokinesis, exocytosis, and apoptosis, among others. They are also directly or indirectly ass
Publicado em: 2010
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4. Genes involved in cell division in mycoplasmas
Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important
Publicado em: 2010
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5. Genes involved in cell division in mycoplasmas
Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important
Genetics and Molecular Biology. Publicado em: 2007
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6. Directed elongation model for microtubule GTP hydrolysis.
We propose a role for GTP hydrolysis in microtubule assembly in which the GTPase reaction serves to stabilize tubulin subunits in the microtubule. The GTPase reaction in tubulin subunits containing GTP at microtubule ends is presumed to occur predominately in subunits at one of the interfaces between a cap of GTP-containing tubulin subunit and a core of GDP-
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7. Steady-state theory of the interference of GTP hydrolysis in the mechanism of microtubule assembly.
A model is presented for the interference of GTP hydrolysis in the mechanism of microtubule assembly. This model is suggested by previous results showing that both GTP and GDP are present at microtubule ends because of GTP hydrolysis and that tubulin does not bind to a GDP-bound end. The analytical theory developed here is aimed at calculation of the steady-
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8. Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.
Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier work, phase changes occur at the microtubule end: the end is either capped with GTP and growing slowly or uncapped and shortening rapidly, and these two regimes a
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9. Hydrolysis of GTP associated with the formation of tubulin oligomers is involved in microtubule nucleation.
Hydrolysis of GTP is known to accompany microtubule assembly. Here we show that hydrolysis of GTP is also associated with the formation of linear oligomers of tubulin, which are precursors (prenuclei) in microtubule assembly. The hydrolysis of GTP on these linear oligomers inhibits the lateral association of GTP-tubulin that leads to the formation of a bidim
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10. The molecular mechanism of inhibition of alpha-type DNA polymerases by N2-(butylphenyl)dGTP and 2-(butylanilino)dATP: variation in susceptibility to polymerization.
Calf thymus DNA polymerase alpha (pol alpha) and bacteriophage T4 DNA polymerase (pol T4) were exploited as model enzymes to investigate the molecular mechanism of inhibitory action of N2-(p-n-butylphenyl)dGTP (BuPdGTP) and 2-(p-n-butyl-anilino)dATP (BuAdATP) on the BuPdNTP-susceptible alpha polymerase family. Kinetic analysis of inhibition of pol alpha with
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11. Estimates of lateral and longitudinal bond energies within the microtubule lattice
We developed a stochastic model of microtubule (MT) assembly dynamics that estimates tubulin–tubulin bond energies, mechanical energy stored in the lattice dimers, and the size of the tubulin-GTP cap at MT tips. First, a simple assembly/disassembly state model was used to screen possible combinations of lateral bond energy (ΔGLat) and longitudinal bond en
The National Academy of Sciences.
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12. Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP
Nitric oxide (NO) affects many physiological systems by activating cGMP signaling cascades through soluble guanylate cyclase (sGC). In the accepted model, NO binds to the sGC heme, activating the enzyme. Here, we report that in the presence of physiological concentrations of ATP and GTP, NO dissociation from the sGC heme is ≈160 times slower than the rate
National Academy of Sciences.