Gtp Binding
Mostrando 1-12 de 1500 artigos, teses e dissertações.
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1. Padronização das técnicas de PNA e PCR em tempo real para detecção das mutações ativadoras no GNAS na síndrome de McCune-Albright / Standardization of the PNA and real time techniques for the detection of activating mutations in the GNAS in McCune-Albright syndrome
The McCune-Albright Syndrome (MAS) is a genetic disease, with incidence estimated at 1/100.000 and 1/1000000 cases per year. MAS is clinically characterized by the triad: bone fibrous dysplasia (FD) café-au-lait skin spots and endocrine hyperfunction, such as: precocious puberty (PP), Cushing s syndrome, hyperthyroidism and acromegaly. The diagnosis of MAS
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/10/2012
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2. Investigação do papel do óxido nítrico e de Rho GTPases na adesão de neutrófilos sob condições inflamatórias = : Investigation of the role of nitric oxide and Rho GTPases in neutrophils adhesion under inflammatory conditions / Investigation of the role of nitric oxide and Rho GTPases in neutrophils adhesion under inflammatory conditions
Durante a resposta inflamatória, os neutrófilos e outros leucócitos aderem ao endotélio, deixando os vasos sanguíneos e movimentando-se ativamente em direção ao foco inflamatório. A migração dos neutrófilos para sítios inflamatórios depende de uma série de eventos adesivos e quimiotáticos, resultantes da ativação de moléculas de adesão com
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/09/2012
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3. Papel da dissulfeto isomerase proteica (PDI) na migração de células musculares lisas vasculares: possível envolvimento de Nox1 NADPH oxidase e RhoGTPases / The role of protein disulfide isomerase (PDI) in vascular smooth muscle cell migration: possible interaction with Nox1 NADPH oxidase and RhoGTPases
A migração de células musculares lisas (VSMC) da camada média do vaso para a íntima é essencial para vasculogênese e contribui para o processo de aterosclerose e estenose após lesão por cateter-balão, caracterizando-se como um importante alvo terapêutico. Diversos trabalhos já demonstraram que fatores de crescimento (como PDGF e FGF) estimulam a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/02/2012
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4. Estudos bioquímicos, funcionais e estruturais da septina humana SEPT2: fatores que determinam a formação de agregados / Functional and structural studies of human SEPT2: determinant factors triggering the sefl-assembly into amyloid fibrils
As septinas fazem parte de uma família de proteínas de ligação ao nucleotídeo guanina. As septinas têm mostrado ter um papel importante na citocinese e outros processos celulares, incluindo a determinação da polaridade celular e reorganização do citoesqueleto. Todos os membros da família de septinas são compostos por três domínios: um N-termina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/10/2011
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5. Estudos funcionais e estruturais das septinas humanas 6, 8 e 10 / Functional and structural studies of human septin 6, 8 and 10
A cell passes through some steps to enable for cell division and all these processes are called Cell Cycle. The spatial and temporal regulation of this process is crucial to maintaining cellular and genetic material. Failure in this process can lead to cell death or genetic changes causing division and unregulated growth of tumors. Among several proteins inv
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/03/2010
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6. Interação entre IQGAP1 e actina mediado por CDC42 e RAC1
IQGAP1 stimulates branched actin filament nucleation by activating N-WASP, which in turn activates the Arp2/3 complex. N-WASP can be activated by other factors, including GTP-bound forms of Cdc42 and Rac1, which also bind IQGAP1. We report here the use of purified proteins for in vitro binding and actin polymerization assays, and of fluorescence resonance en
Publicado em: 2010
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7. Genes involved in cell division in mycoplasmas
Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important
Publicado em: 2010
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8. Generation of diversity in Streptococcus mutans genes demonstrated by MLST
Streptococcus mutans, consisting of serotypes c, e, f and k, is an oral aciduric organism associated with the initiation and progression of dental caries. A total of 135 independent Streptococcus mutans strains from caries-free and caries-active subjects isolated from various geographical locations were examined in two versions of an MLST scheme consisting o
Publicado em: 2010
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9. Structural analyses of rab family GTPases and mechanism of Mafb regulation by the protein TIPRL / Analises estruturais de GTPases da familia RAB e mecanismo de regulção de MAFB pela proteina TIPRL
GTPases of the Rab family are responsible for the intracellular transport of vesicles. Each family member acts on a specific transport pathway and their function is regulated by GTP binding and hydrolysis, cycling between inactive (GDP-bound) and active (GTP-bound) forms. In this work, we describe the crystal structure of inactive and active forms of the GTP
Publicado em: 2007
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10. Genes involved in cell division in mycoplasmas
Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important
Genetics and Molecular Biology. Publicado em: 2007
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11. Capillary electrophoresis-based biomolecular recognition studies / Estudos de reconhecimento biomolecular por eletroforese capilar
This Thesis concerns on the development of capillary electrophoresis-based bioanalytical methods for two distinct applications: DNA-protein binding analysis and monitoring of enzyme-catalyzed GTP hydrolysis. In the first chapter, the feasibility of on-chip electrophoretic mobility-shift assays (EMSA) is investigated. Purified transcription factors c-Jun(AP1)
Publicado em: 2005
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12. Caracterização de uma proteina de 35 KDa isolada de mitocondrias de batata com possivel função termogenica
Early studles from thls laboratory have lndicated that the low degree of coupling between respiration and oxidative phosphorylation in potato mitochondria seems to be related to a 35 KDa protein, present in the inner membrane of those mitochondria, with the ability to translocate H with a: mechanism sensitive to purine nucleotides. In this work, we obtained
Publicado em: 1993