Gpi Proteins
Mostrando 1-12 de 166 artigos, teses e dissertações.
-
1. Large deletion in PIGL: a common mutational mechanism in CHIME syndrome?
Abstract CHIME syndrome is an extremely rare autosomal recessive multisystemic disorder caused by mutations in PIGL. PIGL is an endoplasmic reticulum localized enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which plays a role in the anchorage of cell-surface proteins including receptors, enzymes, and adhesion molecu
Genet. Mol. Biol.. Publicado em: 19/02/2018
-
2. The EG95 antigen of Echinococcus spp. contains positively selected amino acids, which may influence host specificity and vaccine efficacy
Echinococcosis is a worldwide zoonotic parasitic disease of humans and various herbivorous domestic animals (intermediate hosts) transmitted by the contact with wild and domestic carnivores (definitive hosts), mainly foxes and dogs. Recently, a vaccine was developed showing high levels of protection against one parasite haplotype (G1) of Echinococcus granulo
Publicado em: 2010
-
3. Estudo do perfil de expressão gênica na distrofia muscular fácio-escápulo-umeral (FSH) / Study of gene expression profile in facioscapulohumeral muscular dystrophy (FSHD)
FSHD is characterized by a great clinical inter and intrafamilial variability. Approximately 10-20% of patients eventually becoming wheelchair-bound while 20-30% with a shortened D4Z4 array, remains asymptomatic or minimally affected. Interestingly, these cases seem to be concentrated in some particular families, suggesting that some mechanism might be actin
Publicado em: 2009
-
4. Proteinas de superficie de Paracoccidioides brasiliensis / Proteinas de superficie de Paracoccidioides brasiliensis
Paracoccidioides brasiliensis is a temperature dependent dimorphic fungus, the etiological agent of paracoccidioidomycosis. In human, infection starts by inhalation of fungal propagules reaching the pulmonary epithelium, where the morphogenetic conversion is correlated with changes in the cell wall composition, organization and structure. The cell wall const
Publicado em: 2008
-
5. Caracterização funcional dos genes PGA13 e PGA58 de Candida albicans / Functional characterization of PGA13 and PGA58 from Candida albicans
A incidência de infecções por fungos oportunistas na população de pacientes imunocomprometidos tem aumentado nos últimos anos, e estas são, principalmente, causadas por Candida albicans. Este patógeno oportunista pode crescer em diferentes formas, variando de levedura, pseudohifa e hifa e essa transição morfológica está associada com a virulênci
Publicado em: 2008
-
6. Studies of the kinetic characteristics of alkaline phosphatase reconstituted in vesicular systems / Estudos das características cinéticas da fosfatase alcalina reconstituída em sistemas vesiculares
Alkaline phosphatase is a multifunctional enzyme, capable of hydrolyzing phosphate monoesters, pyrophosphate, phosphodiesters, as well as catalyzing transphosphorylation reactions, and it is named "alkaline" due to its ability to perform these reactions more efficiently in pH above the neutral (pH 8-11). The aim of this work was to standardize a methodology
Publicado em: 2008
-
7. Caracterização de microdomínios de membrana resitentes a detergente não iônico em promastigotas de Leishmania (Viannia) braziliensis. Papel dos microdomínios na infectividade. / Characterization of non-ionic detergent resistant membrane microdomains in Leishmania (Viannia) braziliensis promastigotes. Role of these microdmains in the infectivity
Glycoconjugates present in Leishmania surface are an important class of molecules involved in parasite-macrophage interaction. The structural elucidation of Leishmania (Viannia) braziliensis promastigote glycolipids is very relevant because in this specie the glycolipids represent the major promastigote surface glycoconjugate. Six glycolipid fractions, terme
Publicado em: 2006
-
8. Desenvolvimento de um modelo de vacinação contra Toxoplasma gondii empregando adenovírus recombinante
In the present study, genes encoding the SAG1, SAG2 and SAG3 proteins of T. gondii were cloned into replication-deficient recombinant adenoviruses, after being modified for appropriate expression in mammalian cells. Modifications included removal of 3-end sequences encoding the GPI-anchoring motifs and, for SAG3, substitution of the 5´-end encoding the natu
Publicado em: 2005
-
9. Anticorpos contra os componentes da placa aterosclerótica beta2-glicoproteína I e proteínas de choque térmico como fatores de risco para isquemia cerebral aguda
Um terço dos casos de isquemia cerebral não apresenta etiologia clara. Uma resposta humoral contra os componentes da placa aterosclerótica beta2-glicoproteína l (beta2-gpl) e proteínas de choque térmico ("heat-shock proteins", Hsp) pode estar envolvida na patogênese do infarto cerebral. Este estudo de caso-controles inclui um perfil completo de antico
Arquivos de Neuro-Psiquiatria. Publicado em: 2003-09
-
10. Detection of somatic mutations of the PIG-A gene in Brazilian patients with paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal syndrome characterized by intravascular hemolysis mediated by complement, thrombotic events and alterations in hematopoiesis. Basically, the molecular events which underlie the complexity of the syndrome consist of the absence of the glycosylphosphatidylinositol (GPI) anchor as a consequence of
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-06
-
11. Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.
Mannosamine (2-amino-2-deoxy D-mannose) is shown here to block the incorporation of glycosylphosphatidylinositol (GPI) into GPI-anchored proteins. The amino sugar drastically reduced the surface expression of a recombinant GPI-anchored protein in polarized MDCK cells, converted this apical membrane-bound protein to an unpolarized secretory product and blocke
-
12. Gaa1p and Gpi8p Are Components of a Glycosylphosphatidylinositol (GPI) Transamidase That Mediates Attachment of GPI to Proteins
Many eukaryotic cell surface proteins are anchored to the membrane via glycosylphosphatidylinositol (GPI). The GPI is attached to proteins that have a GPI attachment signal peptide at the carboxyl terminus. The GPI attachment signal peptide is replaced by a preassembled GPI in the endoplasmic reticulum by a transamidation reaction through the formation of a
The American Society for Cell Biology.