Glycoprotein Genes
Mostrando 1-12 de 780 artigos, teses e dissertações.
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1. Molecular characterization of Brazilian equid herpesvirus type 1 strains based on neuropathogenicity markers
Partial nucleotide sequences of ORF72 (glycoprotein D, gD), ORF64 (infected cell protein 4, ICP4) and ORF30 (DNA polymerase) genes were compared with corresponding sequences of EHV-1 reference strains to characterize the molecular variability of Brazilian strains. Virus isolation assays were applied to 74 samples including visceral tissue, total blood, cereb
Braz. J. Microbiol.. Publicado em: 2015-06
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2. Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo
OBJECTIVE: To determine whether curcumin reverses the multidrug resistance of human colon cancer cells in vitro and in vivo. METHODS: In a vincristine-resistant cell line of human colon cancer, the cell viability of curcumin-treated cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Rhodamine123 efflux was e
Clinics. Publicado em: 2013-05
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3. Expressão da P-gp, MPR1 e LRP em células-tronco mesenquimais humanas derivadas do líquido amniótico e medula óssea / P-gp, MRP1 and LRP expression in human amniotic fluid and bone marrow derived mesenchymal stem cells
INTRODUÇÃO: O fenótipo de resistência a drogas é caracterizado pela superexpressão das proteínas da família ABC (ATP-Binding Cassette). A Pglicoproteína (P-gp), codificada pelo gene ABCB1, é uma das bombas de efluxo mais estudadas, como agente interferente no tratamento de diversos tipos de câncer, seguida pela proteína MRP1 (Multidrug Resistance
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2012
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4. Avaliação da expressão transiente do gene da glicoproteína do vírus da raiva (RVGP) em células de inseto da linhagem Drosophila melanogaster S2
A raiva é uma enfermidade causada por um vírus do gênero Lyssavirus que afeta várias espécies de mamíferos. Esta doença apresenta um alto custo social e econômico principalmente em países em desenvolvimento. Na superfície do vírus da raiva está localizada a glicoproteína do vírus, reconhecida como antígeno capaz de conferir resposta imunológi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/11/2011
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5. Desenvolvimento e avaliação imunológica de Nanotubos de Carbono funcionalizados com a proteína de envelope de Dengue virus 3
In terms of epidemiologic impact, Dengue (DENV) infections represent the most important infectious disease in Brazil. Consequently, the development of an efficient vaccine is considered a high priority. Due to this fact, many studies are being developed towards this goal, but no vaccine is currently available to the population. Carbon Nanotubes (CNT) have be
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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6. Progress with schistosome transgenesis
Genome sequences for Schistosoma japonicum and Schistosoma mansoni are now available. The schistosome genome encodes ~13,000 protein encoding genes for which the function of only a minority is understood. There is a valuable role for transgenesis in functional genomic investigations of these new schistosome gene sequences. In gain-of-function approaches, tra
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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7. Phenotypic and immunohistochemical characterization of sarcoglycanopathies
INTRODUCTION: Limb-girdle muscular dystrophy presents with heterogeneous clinical and molecular features. The primary characteristic of this disorder is proximal muscular weakness with variable age of onset, speed of progression, and intensity of symptoms. Sarcoglycanopathies, which are a subgroup of the limb-girdle muscular dystrophies, are caused by mutati
Clinics. Publicado em: 2011
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8. Construction and growth properties of bovine herpesvirus type 5 recombinants defective in the glycoprotein E or thymidine kinase gene or both
Bovine herpesvirus type 5 (BoHV-5) is an important pathogen of cattle in South America. We describe here the construction and characterization of deletion mutants defective in the glycoprotein E (gE) or thymidine kinase (TK) gene or both (gE/TK) from a highly neurovirulent and well-characterized Brazilian BoHV-5 strain (SV507/99). A gE-deleted recombinant vi
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-02
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9. Construction and characterization of a bovine herpesvirus 5 mutant with a deletion of the GI, GE and US9 genes
Bovine herpesvirus 5 (BoHV-5) is a important cause of viral encephalitis in cattle in South America. Within the framework of developing a differential vaccine against BoHV-5, a deletion mutant was constructed based on a Brazilian BoHV-5 isolate. The target of the deletions were genes that code proteins implicated in the neurovirulence of BoHV-5, the glycopro
Publicado em: 2010
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10. Non genomic actions of triiodothyronine (T3) on the expression polyadenylation and distribution of TSH granules in thyrotrophs of hypothyroid rats / Ações não genômicas da triiodotironina (T3) sobre a expressão, poliadenilação e distribuição dos grânulos de TSH nos tireotrofos de ratos hipotireiodeos
The thyroid-stimulating hormone (TSH) is the main regulator of the synthesis and secretion of thyroid hormones (TH), which exert a negative feedback mechanism in the pituitary by reducing the synthesis of β and α (CGA - Glycoprotein hormones alpha chain) chains through mechanisms that involve changes in the tra
Publicado em: 2010
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11. ATTENUATION AND IMMUNOGENICITY OF A RECOMBINANT BOVINE HERPESVIRUS 5 DEFECTIVE IN GLYCOPROTEIN E AND THYMIDINE KINASE / ATENUAÇÃO E IMUNOGENICIDADE DE UMA CEPA RECOMBINANTE DO HERPESVÍRUS BOVINO TIPO 5 DEFECTIVA NA GLICOPROTEÍNA E E ENZIMA TIMIDINA QUINASE
O presente trabalho descreve a atenuação/virulência e imunogenicidade de uma cepa recombinante do herpesvírus bovino tipo 5 (BoHV-5) candidata a cepa vacinal. O recombinante BoHV-5gE/TKΔ foi construído a partir da cepa brasileira SV507/99 e contém deleções nos genes da glicoproteína E (gE) como marcador antigênico - e da enzima timidina quinas
Publicado em: 2010
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12. Rabies virus in insectivorous bats: implications in molecular epidemiology of the diversity of genes encoding nucleoprotein and glycoprotein / Vírus da raiva em morcegos insetívoros: implicações em epidemiologia molecular da diversidade dos genes codificadores da nucleoproteína e glicoproteína
As a result of the control of canine rabies in São Paulo State in the last 20 years, rabies in wild animals, mainly in bats, has assumed an increasing importance as the last are currently the most important rabies reservoirs in this State. Despite the fact that bats have maintained epidemiological cycles of rabies for centuries, only in the 50s rabies in in
Publicado em: 2009