Glutamine 5 Fluorouracil
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice
Apolipoprotein E (APOE=gene, apoE=protein) is a known factor regulating the inflammatory response that may have regenerative effects during tissue recovery from injury. We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-trophic nutrient, during tissue recovery after 5-FU-induced int
Braz J Med Biol Res. Publicado em: 28/04/2015
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2. Estudo do papel do Ãxido nÃtrico nas mucosites oral e intestinal induzidas por 5-fluorouracil e metotrexato e efeito da glutamina e alanil-glutamina na mucosite oral induzida por 5-fluorouracil / Study of the paper of nitric oxide in the induced mucosites verbal and intestinal for 5-fluorouracil and metotrexato and effect of the glutamina and alanil-glutamina in the induced verbal mucosite for 5-fluorouracil
A mucosite induzida por quimioterÃpicos à um efeito colateral importante e limitante da terapia do cÃncer, cuja fisiopatologia nÃo à completamente compreendida. O presente estudo visa investigar o papel do Ãxido nÃtrico (NO) na patogÃnese das mucosites oral e intestinal induzidas por 5-fluorouracil (5-FU) e metotrexato (MTX) e os efeitos da glutamina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/04/2007
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3. Restablishement of intestinal barrier function with glutamine, alanyl-glutamine supplementation and peptides enriched on intestinal mucositis induced by 5-Fluorouracyl / Restabelecimento da barreira morfo-funcional intestinal através da suplementação com glutamina, alanil-glutamina e peptídeos, em camundongos com mucosite induzida por 5-fluorouracil
Alterações patológicas nos teciduais podem ser ocasionadas por doenças e antimetabólitos como o 5-Fluorouracil (5-FU), acometendo o sistema digestório. Para que o processo absortivo ocorra normalmente, a barreira epitelial do intestino deve estar íntegra e com taxa de renovação celular adequada. A ação antiproliferativa do 5-FU resulta, principalm
Publicado em: 2006
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4. Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil
Dihydropyrimidine dehydrogenase catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. Its controlled inhibition has become an adjunct target for cancer therapy, since the enzyme is also responsible for the rapid breakdown of the chemotherapeutic drug 5-fluorouracil
Oxford University Press.
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5. Alteration of the Bacillus subtilis glutamine synthetase results in overproduction of the enzyme.
A mutational leading to glutamine auxotrophy was located near a 5-fluorouracil resistance marker in the citB-thyA region of the Bacillus subtilis chromosome. This mutation resulted in a glutamine synthetase with altered kinetic and feedback properties. The specific activity of manganese-stimulated glutamine synthetase activity in crude extracts was 18-fold h
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6. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer.
OBJECTIVE: The objective of this study was to determine whether oral glutamine supplements can protect lymphocyte and gut barrier function in patients with advanced esophageal cancer undergoing radiochemotherapy. SUMMARY BACKGROUND DATA: Glutamine supplements improved protein metabolism in tumor bearing rats who underwent chemotherapy and reduced the toxicit