Glutamate Uptake
Mostrando 1-12 de 265 artigos, teses e dissertações.
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1. Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison
Abstract Background: Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these poisons have many other molecules
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/04/2019
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2. Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition
The present study investigated the effect of silibinin, the principal potential anti-inflammatory flavonoid contained in silymarin, a mixture of flavonolignans extracted from Silybum marianum seeds, on palmitate-induced insulin resistance in C2C12 myotubes and its potential molecular mechanisms. Silibinin prevented the decrease of insulin-stimulated 2-NBDG (
Braz J Med Biol Res. Publicado em: 06/03/2015
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3. Neuroprotection of Persea major extract against oxygen and glucose deprivation in hippocampal slices involves increased glutamate uptake and modulation of A1 and A2A adenosine receptors
Ischemic stroke is characterised by a lack of oxygen and glucose in the brain, leading to excessive glutamate release and neuronal cell death. Adenosine is produced in response to ATP depletion and acts as an endogenous neuromodulator that reduces excitotoxicity. Persea major (Meins.) L.E. Kopp (Lauraceae) is a medical plant that is indigenous to South Brazi
Rev. bras. farmacogn.. Publicado em: 2013-10
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4. GABA and glutamate transporters: new events and function in the vertebrate retina
The neural retina is a highly complex tissue composed of excitatory and inhibitory neurons and glial cells. Glutamate, the main excitatory neurotransmitter, mediates information transfer from photoreceptors, bipolar cells, and ganglion cells, whereas interneurons, mainly amacrine and horizontal cells, use γ-aminobutyric acid (GABA), the main inhibitory neur
Psychol. Neurosci.. Publicado em: 2013
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5. Homocysteine decreases glutamate uptake and Na+, K+-ATPase activity and increases oxidative stress : prevention by vitamin c
No presente estudo, nós investigamos o efeito da administração crônica de homocisteína sobre a captação de glutamato e a atividade da Na+,K+-ATPase, bem como sobre alguns parâmetros de estresse oxidativo (espécies reativas e enzimas antioxidantes como a catalase e superóxido dismutase) em hipocampo de ratos jovens. A influência da vitamina C, um a
Publicado em: 2010
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6. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
This review addresses the mechanisms of methylmercury (MeHg)- induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in as
Publicado em: 2010
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7. Avaliação de parâmetros neuroquímicos em fatias de hipocampo de rato submetidas à privação de oxigênio e glicose
Mesmo a isquemia sendo a terceira causa de morte em países industrializados, os mecanismos relacionados a esta doença ainda continuam polêmicos e obscuros. Utilizou-se a técnica de privação de oxigênio e glicose (OGD) em fatias do hipocampo de rato para investigar parâmetros mitocondriais, neurais, astrogliais e metabólicos no período de isquemia e
Publicado em: 2010
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8. Effects of ZmDof1 and OsDof25 transcriptional factors superexpression on nitrogen usage efficiency in Arabidopsis. / Efeito da superexpressão dos fatores de transcrição ZmDof1 e OsDof25 sobre a eficiência de uso de nitrogênio em Arabidopsis.
To improve nitrogen usage efficiency in plants the rice transcriptional factor OsDof25 was identified and cloned, whose probably orthologe is the maize ZmDof1, already identified and partially characterized. The ZmDof1 was also cloned for comparative analysis with OsDof25, in order to confirm this last one as ZmDof1 orthologe in rice. The constructions for A
Publicado em: 2009
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9. Astrócitos e harmônio da tireóide (T3): desenvolvimento neuronal e neuroproteção
Thyroid hormone (T3) has a significant influence on the development and maturation of the mammalian SNC. T3 modulates neuronal development in an astrocyte-mediated manner, secreting soluble factors and other molecules, as ECM proteins, and regulating neurite outgrowth, neuron proliferation and migration. Astrocytes also participate actively in the neuronal m
Publicado em: 2008
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10. EFEITO NEUROPROTETOR DA CREATINA E AVALIAÇÃO DOS PARÂMETROS CINÉTICOS DA CAPTAÇÃO DE GLUTAMATO INDUZIDOS PELO ÁCIDO GLUTÁRICO NO ESTRIADO DE RATOS / NEUROPROTECTIVE EFFECT OF CREATINE AND EVALUATION OF KINETIC PARAMETERS OF GLUTAMATE UPTAKE INDUCED BY GLUTARIC ACID FROM STRIATUM THE RATS
A acidemia glutárica tipo I (GA-I) é um erro inato do metabolismo (EIM) caracterizada bioquimicamente pelo acúmulo principal de ácido glutárico (GA) e ácido 3-hidroxiglutárico (3-OH-GA), e patologicamente por uma característica degeneração estriatal. Devido à escassez de medidas terapêuticas efetivas para essa acidemia, vários estudos têm inves
Publicado em: 2008
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11. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in ast
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-03
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12. Multiple sclerosis: high resolution magnetic resonance spectroscopy and correlation with inflammatory course / Esclerose multipla : espectroscopia de protons de resolução do liquor e correlação com atividade inflamatoria
We studied cerebrospinal fluid (CSF) of 24 patients with multiple sclerosis (MS) and 11 control subjects by high resolution proton MR spectroscopy. The application of 1 H magnetic resonance spectroscopy in cerebrospinal fluid (CSF) analysis may detect metabolites in normal and pathological conditions. The purpose of this work was to evaluate what biochemical
Publicado em: 2007