Glucose Metabolism Disorders
Mostrando 25-36 de 43 artigos, teses e dissertações.
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25. Chemical synthesis of dienantin andda trienantin, and toxicological evaluation of chronic consumption in rats. / Síntese química da dienantina e da trienantina e avaliação toxicológica do consumo crônico em ratos.
Medium chain triacylglycerols (MCT), as found in milk fat and coconut and palm oil, are recommended as a source of rapidly available energy for pre- and postchirurgical patients, and for those with burns, cancers or presenting disorders associated with the absorption and/or metabolism of long chain triacylglycerols. Typically, however, short and medium chain
Publicado em: 2004
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26. Transoperatory infusion of aminoacids and glucose. / Infusão transoperatória de aminoácidos e glicose.
It s been described for almost 50 years that weight loss at the preoperative period increases the postoperative mortality. Many factors, besides the malnutrition itself, contribute to this situation, for example, the patient illness, the surgical procedure, associated infections and others. Its also known that in trauma, organic or not, there are disorders
Publicado em: 2002
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27. Sobrecarga salinas cronica em ratos Wistar eleva a pressão arterial e aumenta o metabolismo da glicose, sem modificar a sensibilidade a insulina / Sobrecarga salina cronica em ratos wistar eleva a pressao arterial e aumenta o metabolismo da glicose, sem modificar a sensibilidade a insulina
During the human aging process, it is observed an increase in arterial pressure and a higher prevalence of carbohydrate metabolism disorders, like insulin resistance on glucose uptake, glucose intolerance, and diabetes mellitus type II. It is an open question if there is a cause-effect association between hypertension and insulin resistance or if there is on
Publicado em: 1995
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28. Role of insulin in the intermediary metabolism of the activated thymic-derived lymphocyte.
The hypothesis that a role for insulin in the metabolism of T cells would be evident after cell activation when receptors appear was tested to validate the T cell model and to analyze the mechanism by which insulin may function in immunoregulation. Measuring the flux rates of 3-O-[methyl-3H]-D-glucose and aminoisobutyric acid, alpha-[1-14C], lactate producti
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29. Evolution of diabetes mellitus in a case of Friedreich's ataxia
A 12 year old girl with Friedreich's ataxia, in whom progression from chemical to severe insulin-dependent diabetes mellitus occurred over a two year period, is presented. During the phase of subclinical diabetes her plasma immunoreactive insulin response to oral glucose was markedly increased, but when she became symptomatic gross insulin deficiency had sup
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30. Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates
Corticotropin-releasing factor (CRF) is a neuropeptide involved in integrating the behavioral, autonomic, and hormonal responses to stress within the central nervous system. Patients suffering from depression have abnormal activity in stress responsive brain regions and elevated cerebrospinal fluid CRF. The DSM-IV criteria for major depressive disorder inclu
National Academy of Sciences.
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31. Role of AMP-activated protein kinase in mechanism of metformin action
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin’s beneficial effects on circulating lipids have been linked to reduced fatty liver. AMP-activated protein kinase (AMPK) is a
American Society for Clinical Investigation.
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32. Activation of memory circuits during cue-elicited cocaine craving.
Evidence accumulated over more than 45 years has indicated that environmental stimuli can induce craving for drugs of abuse in individuals who have addictive disorders. However, the brain mechanisms that subserve such craving have not been elucidated. Here a positron emission tomographic study shows increased glucose metabolism in cortical and limbic regions
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33. Glial reduction in the subgenual prefrontal cortex in mood disorders
Mood disorders are among the most common neuropsychiatric illnesses, yet little is known about their neurobiology. Recent neuroimaging studies have found that the volume of the subgenual part of Brodmann’s area 24 (sg24) is reduced in familial forms of major depressive disorder (MDD) and bipolar disorder (BD). In this histological study, we used unbiased s
The National Academy of Sciences.
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34. Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction
Calorie restriction (CR) alleviates insulin resistance and has a beneficial effect on numerous metabolic disorders, yet the underlying mechanism has not been fully elucidated. In the present study, we found that CR of mice (60% of the diet consumption compared with ad libitum mice) reduces the expression levels of Grb2 in skeletal muscle, an insulin target t
American Physiological Society.
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35. Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle
The nemaline myopathies (NMs) are a clinically and genetically heterogeneous group of disorders characterized by nemaline rods and skeletal muscle weakness. Mutations in five sarcomeric thin filament genes have been identified. However, the molecular consequences of these mutations are unknown. Using Affymetrix oligonucleotide microarrays, we have analyzed t
The National Academy of Sciences.
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36. Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension
Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4
American Society for Clinical Investigation.