Glomerular Sclerosis
Mostrando 1-12 de 43 artigos, teses e dissertações.
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1. Proximal tubular dysfunction as an indicator of chronic graft dysfunction
New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-03
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2. Are the current chronic allograft nephropathy grading systems sufficient to predict renal allograft survival?
A major problem in renal transplantation is identifying a grading system that can predict long-term graft survival. The present study determined the extent to which the two existing grading systems (Banff 97 and chronic allograft damage index, CADI) correlate with each other and with graft loss. A total of 161 transplant patient biopsies with chronic allogra
Brazilian Journal of Medical and Biological Research. Publicado em: 30/09/2008
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3. Papel do fósforo e do paratormônio na progressão da doença renal crônica / Role of phosphorus and parathyroid hormone in the progression of chronic kidney disease
Introdução: Os mecanismos envolvidos na progressão da doença renal crônica (DRC) independentemente de sua etiologia, não estão totalmente esclarecidos. O controle do fósforo(P) sérico é uma meta essencial a ser alcançada no tratamento de pacientes com DRC. Inicialmente, a importância deste controle era atribuída a participação do P na patogên
Publicado em: 2008
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4. BIOATIVIDADE DE EXTRATOS VEGETAIS NO CONTROLE DE Sitophilus oryzae (LINNÉ, 1763) EM ARROZ / BIOACTIVITY OF VEGETABLE EXTRACTS ON THE CONTROL OF Sitophilus oryzae (LINNÉ, 1763) IN RICE
The continuous growth of the world population, intensive competition among humans and plant pests for the same food sources, the resistence to existing inseticides by some insects and the persistence of residues in the environment and food created the necessity for new insecticides. In this research field, vegetable species appear as a promising source of ne
Publicado em: 2007
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5. Effect of dietary linoleic acid on the progression of chronic renal failure in rats
The role of linoleic acid in chronic renal failure (CRF) is controversial. In the present study 21 male Wistar rats submitted to 5/6 renal mass reduction (R) and 16 normal controls (C) were fed a supplement (S) or normal (N) linoleic acid diet for 60 days starting 10 days after CRF. As expected, serum creatinine, cholesterol and triglycerides (mean ± SEM) w
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-05
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6. Classificação de glomerulonefrites : proposta para uma nova abordagem baseada em estudo de 700 biopsias renais em microscopia comum, imunofluorescente e eletronica
Past eighty years since Volhard and Fahr put some order in the existent chaos, classification of glomerulonephritis is still a challenge for pathologists and nephrologists. Even the last proposal for classification by the World Health Organization (WHO) is not entirely satisfactory. Three factors contribute for making classification of glomerulonephritis dif
Publicado em: 1997
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7. Serial micropuncture analysis of glomerular function in two rat models of glomerular sclerosis.
We have recently developed a micropuncture technique to assess repeatedly function of the same nephrons in chronic renal disease and subsequently examine the morphology of their glomeruli by serial thin-section histological analysis. Using this approach, a potential causal linkage between early functional patterns and late structural abnormalities was examin
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8. Light and electron microscopical studies of focal glomerular sclerosis
Renal biopsy material from seven cases of the nephrotic syndrome due to focal glomerular sclerosis has been studied by light, electron, and immunofluorescent microscopy. The nature of glomerular basement membrane changes and the scar tissue was also studied. It was found that the glomerular basement membrane and mesangial matrix formed the major components o
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9. Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome.
Functional and morphologic measurements were performed in Munich-Wistar rats after a single central venous injection of puromycin aminonucleoside (PA) or saline vehicle (sham). During phase I, PA rats exhibited overt nephrotic syndrome and impaired glomerular filtration, primarily due to a reduction in the glomerular capillary ultrafiltration coefficient. Th
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10. New insights into mechanisms of immune glomerular injury.
Although glomerular disease remains the most common cause of end-stage renal disease worldwide, major advances have been made recently in understanding the cellular and molecular mechanisms that mediate these disorders. The nephrotic syndrome in noninflammatory lesions such as minimal change or focal sclerosis and membranous nephropathy results from disorder
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11. Chronic glucocorticoid therapy amplifies glomerular injury in rats with renal ablation.
Functional and/or structural measurements were performed in eight groups of Munich-Wistar rats after five-sixths nephrectomy. Groups 1 and 5 received no therapy. Groups 2 and 6 received daily doses of methylprednisolone (MP). Groups 3 and 7 received MP plus the angiotensin I converting enzyme inhibitor (CEI), benzazepril. Groups 4 and 8 received CEI alone. G
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12. IgA localisation in glomerular diseases.
The structural changes found on light and electron microscopy study of 25 renal biopsy specimens that showed significant glomerular IgA deposition on immunofluorescence were correlated with relevant clinical data. The morphology of a wide range of glomerulopathies seeen included mesangial proliferative (60%), membranous (12%), rapidly progressive proliferati