Glial Fibrillary Acid Protein Gfap
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Respostas de recuperação tecidual no cerebelo e córtex de filhotes expostos às crises convulsivas maternas / Response of tissue recovery in cerebellum and córtex of pups exposed to maternal seizures.
Objective: This study aimed to examine possible changes arising of hypoxic-ischemic insults in brain regions such as cerebellum and cortex at different stages of postnatal development of pups subjected to maternal seizures during intrauterine life. Methods: Wistar rats were subjected to the model of epilepsy induced by pilocarpine, mated and the seizure freq
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/05/2011
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2. Avaliação de parâmetros neuroquímicos em fatias de hipocampo de rato submetidas à privação de oxigênio e glicose
Mesmo a isquemia sendo a terceira causa de morte em países industrializados, os mecanismos relacionados a esta doença ainda continuam polêmicos e obscuros. Utilizou-se a técnica de privação de oxigênio e glicose (OGD) em fatias do hipocampo de rato para investigar parâmetros mitocondriais, neurais, astrogliais e metabólicos no período de isquemia e
Publicado em: 2010
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3. Efeitos da administração intraestriatal aguda de ácido quinolítico sobre o citoesqueleto de células neurais de ratos
In the present study we investigated the effect of in vivo intrastriatal injection of quinolinic acid (QA) on rat cytoskeleton proteins in astrocytes and neurons of young rats at early stages (30 min) after infusion. Intrastriatal QA injection is an excitotoxic model of Huntington´s Disease (HD). Results showed that QA (150¿mol/0.5¿L) significantly increa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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4. Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments.
A clone encoding mouse glial fibrillary acidic protein (GFAP) was isolated from a cDNA library constructed so as to express the cloned sequences. The library was screened using a GFAP-specific polyclonal antiserum; a single bacterial colony expressing GFAP was identified. The complete sequence of the cDNA insert in this clone is presented, encompassing 2.5 k
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5. Molecular cloning and primary structure of human glial fibrillary acidic protein.
Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Determination of the primary structure of this protein should be of importance for understanding the functional role it plays in astroglia. Therefore, we isolated a cDNA clo
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6. Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family.
We report the complete sequence of the gene encoding mouse glial fibrillary acidic protein (GFAP), the intermediate filament (IF) protein specific to astrocytes. The 9.8 kb gene includes nine exons separated by introns ranging in size from 0.2 to 2.5 kb. A comparison of the organization of the GFAP gene with that of genes encoding other IF proteins reveals t
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7. Hematopoietic progenitors express neural genes
Bone marrow, or cells selected from bone marrow, were reported recently to give rise to cells with a neural phenotype after in vitro treatment with neural-inducing factors or after delivery into the brain. However, we showed previously that untreated bone marrow cells express products of the neural myelin basic protein gene, and we demonstrate here that a su
National Academy of Sciences.
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8. Localization of Brain Endothelial Luminal and Abluminal Transporters with Immunogold Electron Microscopy
Summary: Immunogold electron microscopy has identified a variety of blood-brain barrier (BBB) proteins with transporter and regulatory functions. For example, isoforms of the glucose transporter, protein kinase C (PKC), and caveolin-1 are BBB specific. Isoform 1 of the facilitative glucose transporter family (GLUT1) is expressed solely in endothelial (and pe
The American Society for Experimental NeuroTherapeutics.
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9. Bipotential precursors of putative fibrous astrocytes and oligodendrocytes in rat cerebellar cultures express distinct surface features and "neuron-like" gamma-aminobutyric acid transport.
When postnatal rat cerebellar cells were cultured in a chemically defined, serum-free medium, the only type of astrocyte (defined by the expression of the glial fibrillary acidic protein, GFAP) present was unable to accumulate gamma-[3H]aminobutyric acid (GABA), did not express surface antigens recognized by two monoclonal antibodies, A2B5 and LB1, and showe
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10. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex
We characterize the survival, migration, and differentiation of human neurospheres derived from CNS stem cells transplanted into the ischemic cortex of rats 7 days after distal middle cerebral artery occlusion. Transplanted neurospheres survived robustly in naive and ischemic brains 4 wk posttransplant. Survival was influenced by proximity of the graft to th
National Academy of Sciences.
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11. The possible role of hypoxia in the formation of axonal bulbs.
AIMS: To assess the possible role of hypoxia in the formation of axonal bulbs. METHODS: Study material comprised sections from 28 brains showing evidence of cerebral hypoxia with no history of head injury, four with a history of head trauma but no evidence of hypoxic change, eight with a history of head trauma and hypoxic change, and four from control brains