Glatiramer Acetate
Mostrando 1-12 de 19 artigos, teses e dissertações.
-
1. Pregnancy and multiple sclerosis : the initial results from a Brazilian database / Gravidez e esclerose múltipla : resultados preliminares de base de dados Brasileira
Propósito: O manejo da gravidez cria um desafio extra aos médicos e aos pacientes com esclerose múltipla (EeM). Eexistem poucos trabalhos relatando bases de dados neste tema. Método: Base de dados brasileira de nove centros clínicos e de pesquisa na EeM, com dados completos de 47 mulheres grávidas (49 gestações). Resultados: Apesar da exposição a d
Publicado em: 2011
-
2. The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model
The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
-
3. Influence of Glatiramer acetate on the synaptic stability and glial reaction during the EAE and after motor root avulsion / Influencia do acetato de glatiramer (AG) sobre a estabilidade sinaptica e reação glial durante o curso da EAE e apos avulsão de raizes motoras
Multiple sclerosis (MS) is an inflammatory and demyelinating disease, which etiology is unknown. Although it is the result of a major autoimmune response. The Glatiramer acetate (GA) is a drug used to treat MS and is composed by four peptides homologous to the myelin basic protein (MBP), that is able to reduce the exacerbation and injuries to the CNS. Nevert
Publicado em: 2009
-
4. Esclerose multipla : mediadores da resposta inflamatoria associadas a ressonancia magnetica quantitativa / Quantitative MRI and CSF inflammatory mediators in a sample of brazilian multiple sclerosis population : a prospective study
Quantitative MRI and CSF inflammatory mediators in a sample of brazilian multiple sclerosis population: a prospective study. Multiple sclerosis (MS) is referred to as a chronic inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS), with a highly variable clinical course and prognosis. This is a prospective study to i
Publicado em: 2009
-
5. Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
We examined the effect of glatiramer acetate, a random copolymer of alanine, lysine, glutamic acid, and tyrosine, on antigen-specific T-cell responses in patients with multiple sclerosis (MS). Glatiramer acetate (Copaxone) functioned as a universal antigen, inducing proliferation, independent of any prior exposure to the polymer, in T-cell lines prepared fro
American Society for Clinical Investigation.
-
6. Expression of Urokinase Plasminogen Activator Receptor on Monocytes from Patients with Relapsing-Remitting Multiple Sclerosis: Effect of Glatiramer Acetate (Copolymer 1)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system in which peripheral blood monocytes play an important role. We have previously reported that patients with chronic progressive MS (CPMS) have significantly increased numbers of circulating monocytes which express the urokinase plasminogen activator receptor (uPAR). In the
American Society for Microbiology.
-
7. Modelling the cost effectiveness of interferon beta and glatiramer acetate in the management of multiple sclerosis
BMJ Group.
-
8. Glatiramer acetate (Copaxone) therapy induces CD8+ T cell responses in patients with multiple sclerosis
Glatiramer acetate (GA; Copaxone) is a random copolymer of glutamic acid, lysine, alanine, and tyrosine that is used therapeutically in patients with multiple sclerosis (MS). To investigate the mechanism of the drug’s immunomodulatory effect, we used immunophenotypic approaches to characterize the precise nature of GA-induced T cell responses. We demonstra
American Society for Clinical Investigation.
-
9. Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ
The ability of a remedy to modulate the pathological process in the target organ is crucial for its therapeutic activity. Glatiramer acetate (GA, Copaxone, Copolymer 1), a drug approved for the treatment of multiple sclerosis, induces regulatory T helper 2/3 cells that penetrate the CNS. Here we investigated whether these GA-specific T cells can function as
National Academy of Sciences.
-
10. Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications
Glatiramer acetate (GA, Copaxone, Copolymer 1) is an approved drug for the treatment of multiple sclerosis and is highly effective in the suppression of experimental autoimmune encephalomyelitis in various species. The mode of action of GA is by initial strong promiscuous binding to MHC molecules and consequent competition with various myelin antigens for th
National Academy of Sciences.
-
11. The present efficacy of multiple sclerosis therapeutics: Is the new 66% just the old 33%?
A challenge for the clinician treating patients with multiple sclerosis (MS) is to determine the most effective treatment while weighing the benefits and risks. Results of the phase 2 and phase 3 studies on natalizumab were received with great interest, in part due to the “improved” risk reduction for relapse rate, disease progression, and MRI metrics ob
American Academy of Neurology.
-
12. T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
The effects of the adaptive immune system on the cognitive performance and abnormal behaviors seen in mental disorders such as schizophrenia have never been documented. Here, we show that mice deprived of mature T cells manifested cognitive deficits and behavioral abnormalities, which were remediable by T cell restoration. T cell-based vaccination, using gla
National Academy of Sciences.