Genotoxicity
Mostrando 37-48 de 262 artigos, teses e dissertações.
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37. Cytotoxicity and genotoxicity of calcium silicate-based cements on an osteoblast lineage
Abstract Several calcium silicate-based biomaterials have been developed in recent years, in addition to Mineral Trioxide Aggregate (MTA). The aim of this study was to evaluate the cytotoxicity, genotoxicity and apoptosis/necrosis in human osteoblast cells (SAOS-2) of pure calcium silicate-based cements (CSC) and modified formulations: modified calcium silic
Braz. oral res.. Publicado em: 20/05/2016
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38. The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon
Abstract Andirobeira is an Amazonian tree, the seeds of which produce a commercially valuable oil that is used in folk medicine and in the cosmetic industry. Andiroba oil contains components with anti-inflammatory, cicatrizing and insect-repellant actions. However, virtually nothing is known of the safety of this oil for humans. The aim of this work was ther
Genet. Mol. Biol.. Publicado em: 13/05/2016
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39. Molecular and cytogenetic assessment of Dipterygium glaucum genotoxicity
RESUMO O objetivo do presente estudo foi avaliar a genotoxicidade do Dipterygium glaucum que se desenvolve amplamente no deserto da Arábia Saudita produzindo produtos de ação protetora à base de plantas. Este trabalho é uma pesquisa pioneira no assunto devido à falta de pesquisas sobre espécies de plantas e à sua mutagenicidade, genotoxicidade e efei
An. Acad. Bras. Ciênc.. Publicado em: 29/04/2016
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40. Protective effects of acerola juice on genotoxicity induced by iron in vivo
Abstract Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Acerola is considered a functional fruit due to its h
Genet. Mol. Biol.. Publicado em: 2016-03
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41. Genotoxic evaluation of the River Paranaíba hydrographic basin in Monte Carmelo, MG, Brazil, by the Tradescantia micronucleus
Abstract Pollutants have adverse effects on human health and on other organisms that inhabit or use water resources. The aim of the present study was to assess the environmental quality of three watercourses in Monte Carmelo, MG, Brazil, using the micronucleus test on Tradescantia. For each treatment, 15 plants were exposed to water samples for 24 h. The con
Genet. Mol. Biol.. Publicado em: 2015-12
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42. DNA damage in the kidney tissue cells of the fish Rhamdia quelen after trophic contamination with aluminum sulfate
Abstract Even though aluminum is the third most common element present in the earth's crust, information regarding its toxicity remains scarce. It is known that in certain cases, aluminum is neurotoxic, but its effect in other tissues is unknown. The aim of this work was to analyze the genotoxic potential of aluminum sulfate in kidney tissue of the fish Rham
Genet. Mol. Biol.. Publicado em: 24/11/2015
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43. Feeding Deterrent and Genotoxicity Analysis of a novel Phytopesticide by using Comet Assay against Helicoverpa armigera (HÜbner) (Lepidoptera: Noctuidae)
Newly developed Phytopesticidal formulations from pongam and neem oils were evaluated for their feeding deterrent activity using leaf disc choice and no-choice methods, and genotoxic study using comet assay against Helicoverpa armigera at different concentrations of 5, 10, 15, and 20 ppm. Among various phytopesticidal formulations, neem and pongam oils at 1:
Braz. arch. biol. technol.. Publicado em: 2015-08
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44. Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An
Braz J Med Biol Res. Publicado em: 21/07/2015
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45. Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group
Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group. However, we synthesised nitroimidazoles with activity against the trypomastigotes of Trypanosoma cruzi, but that were not genotoxic. Herein, nitroimidazoles (11-19) bearing different substituent groups
Mem. Inst. Oswaldo Cruz. Publicado em: 26/05/2015
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46. DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in th
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 15/05/2015
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47. Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá
Abstract The species Maytenus guyanensis Klotzsch ex Reissek, Celastraceae, present a wide variety of possible pharmacological activities and its roots and stems are used by popular medicine in the western Amazon rainforest. Few studies have demonstrated the genotoxic safety of the popular use of this species, and owing to this, the present study aimed to pe
Rev. bras. farmacogn.. Publicado em: 2015-04
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48. Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
Jatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.2
Genet. Mol. Biol.. Publicado em: 2015-03