Genomic Imprinting
Mostrando 25-36 de 124 artigos, teses e dissertações.
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25. Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster
Genomic imprinting is an epigenetic process that results in the preferential silencing of one of the two parental copies of a gene. Although the precise mechanisms by which genomic imprinting occurs are unknown, the tendency of imprinted genes to exist in chromosomal clusters suggests long-range regulation through shared regulatory elements. We characterize
American Society for Microbiology.
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26. Shared Role for Differentially Methylated Domains of Imprinted Genes
For most imprinted genes, a difference in expression between the maternal and paternal alleles is associated with a corresponding difference in DNA methylation that is localized to a differentially methylated domain (DMD). Removal of a gene's DMD leads to a loss of imprinting. These observations suggest that DMDs have a determinative role in genomic imprinti
American Society for Microbiology.
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27. Patterns of inheritance of the symptoms of Huntington's disease suggestive of an effect of genomic imprinting.
The interaction of symptomatology (rigidity/chorea) in Huntington's disease (HD) with age of onset (AO) was examined using data from the Research Roster for Huntington's Disease Patients and Families. It was shown that AO varies between families and between paternal and maternal transmission and that rigidity is associated specifically with very early onset,
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28. Genomic Imprinting
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29. Genomic imprinting and assisted reproduction
Imprinted genes exhibit a parent-of-origin specific pattern of expression. Such genes have been shown to be targets of molecular defects in particular genetic syndromes such as Beckwith-Wiedemann and Angelman syndromes. Recent reports have raised concern about the possibility that assisted reproduction techniques, such as in vitro fertilization or intracytop
BioMed Central.
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30. Symposium on genomic imprinting, Manchester
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31. Genomic Imprinting: Causes and Consequences
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32. Roles for genomic imprinting and the zygotic genome in placental development
The placenta contains several types of feto-maternal interfaces where zygote-derived cells interact with maternal cells or maternal blood for the promotion of fetal growth and viability. The genetic factors regulating the interactions between different cell types within feto-maternal interfaces and the relative contributions of the maternal and zygotic
The National Academy of Sciences.
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33. Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes around imprinting control centers (ICs) is regarded as a hallmark for the coordinated imprinted regulation. Hence imprinted clusters might be structurally disti
Cold Spring Harbor Laboratory Press.
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34. Theory of genomic imprinting conflict in social insects
BioMed Central.
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35. The impact of genomic imprinting for neurobehavioral and developmental disorders
American Society for Clinical Investigation.
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36. Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages
Imprinting is an epigenetic modification leading to monoallelic expression of some genes, and disrupted imprinting is believed to be a barrier to human stem cell transplantation, based on studies that suggest that epigenetic marks are unstable in mouse embryonic germ (EG) and embryonic stem (ES) cells. However, stem cell imprinting has not previously been ex
National Academy of Sciences.