Genic Regulation
Mostrando 1-12 de 13 artigos, teses e dissertações.
-
1. Aplicação de métodos estatísticos e computacionais para o estudo da cis-regulação da expressão gênica / Aplication of computational and statistical methods for the study of cis-regulation of genic expression
Ferramentas bioinformática têm se tornado a escolha para auxiliar pesquisadores tanto para a anotação de novos genes, como para estudar genes em condições fisiológicas de interesse. Entre essas ferramentas destacam-se os algoritmos de agrupamento filogenético e os algoritmos de predição de padrões curtos de DNA, como, por exemplo, predições de s
Publicado em: 2010
-
2. Estudo comparativo do efeito da Echinácea purpúrea e sorafenibe em células de adenocarcinoma renal humano em cultura / Comparative study of the effect of Echinacea purpurea and sorafenib in human renal adenocarcinoma cells in culture
Introduction: The renal cell carcinoma (CR) is relatively rare compared to other cancers. One of the most potent tumor mitogen, vascular endothelial growth factor, VEGF is regulated by numerous pathways, especially Ras and Akt, which are targets of many therapeutic agents, among them sorafenib. These signaling pathways play an important role in the developme
Publicado em: 2010
-
3. Identificação de genes associados a produção de ocratoxina A em Aspergillus westerdijkiae
Mycotoxins, secondary metabolites of fungi, are toxic compounds found in great variety of foods, and when ingested can be very hazardous to animal and human health. Among the diverse mycotoxins, special interest has been given to the ochratoxin A (OA), produced by some species of Aspergillus and Penicillium. This mycotoxin is frequently found mainly in food
Publicado em: 2009
-
4. Genic expression alterations in the tolerance to LPS : B lymphocyte in the genic regulation of the tolerance / Alterações de expressão gênica na tolerância ao LPS: análise da participação dos linfócitos B na regulação gênica da tolerância
Sepses are caused by microorganisms such as: Gram-negative bacteria, Gram-positive bacteria, fungus and virus. Several sepses and the septic shock have been associated with the mortality rates from 40 to 60%. One of the most important events for the septic evolution is the apoptosis cells of the immune system. The cells immune system elimination compromises
Publicado em: 2008
-
5. Expression of gap junction proteins, the connexins, in normal and neoplastic osseous tissues from dogs / Estudo da expressão das proteínas de junções intercelulares do tipo Gap, as conexinas, em tecido ósseo normal e neoplásico de cães
Increasing evidence indicates that junctional communiction by gap juctions has a critical role in a bone physiology. The main connexin (Cx) express involved in development, differentiation and regulation of tissue growth, is the called Cx43. However, other, two connexis are expressed: Cx45 and Cx46. Cx46 is retained as monomers in a trans-golgi compartment o
Publicado em: 2008
-
6. Estudo in silico de genes que codificam fatores de transcriÃÃo responsivos Ãseca, salinidade e congelamento nos genomas do eucalipto, cana e arroz
Abiotic stresses are the most responsable for causing changes in plant growth and development. The plants, in counterpart, make use of a variety of responses in order to maintain their metabolic and physiological processes. One of the main plants responses to environmental conditions alterations is the additional regulation of expression. Moreover, the biosy
Publicado em: 2007
-
7. Identification and selection of new human genes associated with tumors from the Transcript Finishing Initiative (TFI) Project data. / Identificação e seleção de novos genes humanos associados a tumores a partir de dados obtidos no projeto Transcript Finishing Initiative (TFI)
Após o seqüenciamento completo do genoma humano, a busca e caracterização do conjunto completo de genes humanos constitui-se no principal desafio nesta área de investigação, sendo o passo limitante para o progresso na exploração dos dados contidos no seqüenciamento deste genoma. O projeto de transcriptoma denominado "Transcript Finishing Initiative
Publicado em: 2007
-
8. Regulação da resposta transcricional a estresses ambientais em fungos: análise de "microarrays" de cDNAs de Trichoderma reesei / Regulation of the transcriptional response to environmental stresses in fungi: analysis of cDNA microarrays from Trichoderma reesei
A grande diversidade de organismos que hoje encontramos em nosso planeta se deve à adaptação às diferentes condições ambientais de cada nicho ecológico existente e à resposta adaptativa originária das mudanças dessas condições. Pode-se considerar que a etapa inicial do processo de adaptação seja a reprogramação da expressão gênica dum organ
Publicado em: 2006
-
9. Impactos do princípio da dignidade humana no direito a vida do embrião
The theme of this M.A. dissertation is the analysis of the impact of the principle of dignity of human beings regarding the right to life of embryos, in face of new scientific techniques in the field of biomedicine. Initially, the approach is on ethical aspects of bioethics and its importance to the bio-law, highlighting the need of specific and comprehensiv
Publicado em: 2006
-
10. Change of gene frequencies by natural selection under population number regulation.
By incorporating a population number regulating mechanism into the formulation of genic selection involving a pair of alleles (A1 and A2) with respective frequencies x and I-x, it is shown that the change of x in one generation is given by deltax = sx(1-x)/W, in which W is the mean absolute selective value (in Wright's sense). It is also shown that, in the p
-
11. On the stability of dispensable constituents of the eukaryotic genome: stability of coding sequences versus truly hypervariable sequences in a clonal vertebrate, the amazon molly, Poecilia formosa.
In clonal unisexual vertebrates, the genes specifying the males become dispensable. To study the fate of such genes the gynogenetic all-female fish Poecilia formosa was treated with androgens. Phenotypic males were obtained that exhibited the complete set of male characteristics of closely related gonochoristic species, including body proportions, pigmentati
-
12. Phosphoglucose Isomerase Expression in Species of Clarkia with and without a Duplication of the Coding Gene
The duplication of the nuclear gene specifying the cytosolic isozyme of phosphoglucose isomerase (PGI; EC 5.3.1.9) arose within Clarkia, a genus of annual plants native to California, and now characterizes about half of the diploid species of this genus. Evidence obtained by immunological inhibition and titration of crude leaf extracts demonstrated that spec