Genetic Modulation
Mostrando 1-12 de 201 artigos, teses e dissertações.
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1. Influence of genetic regulatory effects modified by environmental immune activation on periapical disease
Abstract: The objective of this study was to compare the periradicular responses in endodontic infections among members of two populations: an urban Brazilian population and a non-mixed indigenous population. Samples were collected immediately and 7 days after the cleaning and shaping procedures (after reducing the intracanal microbial load) in an attempt to
Braz. oral res.. Publicado em: 02/12/2019
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2. Pioneering studies on monogenic central precocious puberty
ABSTRACT Pubertal timing in humans is determined by complex interactions including hormonal, metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is defined as the premature reactivation of the hypothalamic-pituitary-gonadal axis, starting before the ages of 8 and 9 years in girls and boys, respectively; familial CPP is def
Arch. Endocrinol. Metab.. Publicado em: 22/08/2019
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3. RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae
Abstract RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein compl
Genet. Mol. Biol.. Publicado em: 2017-03
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4. MMP1-1607 polymorphism increases the risk for periapical lesion development through the upregulation MMP-1 expression in association with pro-inflammatory milieu elements
ABSTRACT Increased matrix metalloproteinases (MMPs) activity is a hallmark of periapical granulomas. However, the factors underlying the MMPs expression modulation in healthy and diseased periapical tissues remains to be determined. Objective In this study, we evaluated the association between the MMP1-1607 polymorphism (rs1799750) and pro-inflammatory mil
J. Appl. Oral Sci.. Publicado em: 2016-08
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5. Impact of the age of Biomphalaria alexandrina snails on Schistosoma mansoni transmission: modulation of the genetic outcome and the internal defence system of the snail
Of the approximately 34 identified Biomphalaria species, Biomphalaria alexandrina represents the intermediate host of Schistosoma mansoni in Egypt. Using parasitological and SOD1 enzyme assay, this study aimed to elucidate the impact of the age of B. alexandrina snails on their genetic variability and internal defence against S. mansoni infection. Susceptibl
Mem. Inst. Oswaldo Cruz. Publicado em: 09/06/2015
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6. Wavelength assignment using a hybrid evolutionary computation to reduce cross-phase modulation
In this paper, we propose a hybrid methodology based on Graph-Coloring and Genetic Algorithm (GA) to solve the Wavelength Assignment (WA) problem in optical networks, impaired by physical layer effects. Our proposal was developed for a static scenario where the physical topology and traffic matrix are known a priori. First, we used fixed shortest-path routin
J. Microw. Optoelectron. Electromagn. Appl.. Publicado em: 2014-06
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7. Periodontal disease: a genetic perspective
Periodontitis is a multifactorial disease that causes tooth loss. The complex pathogenesis of periodontitis implies the involvement of a susceptible host and a bacterial challenge. Many studies have provided a valuable contribution to understanding the genetic basis of periodontal disease, but the specific candidate genes of susceptibility are still unknown.
Braz. oral res.. Publicado em: 2012
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8. Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining
Our mutagenesis group has been studying with important economic drivers of our state, such as agriculture, the footwear and leather industry and open-cast coal mining. Working conditions in these sectors have potentially harmful to humans. The aim of these studies is to determine the health risk of workers by biomonitoring subjects exposed to genotoxic agent
Genet. Mol. Biol.. Publicado em: 2012
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9. Análise de genes modificadores relacionados à gravidade clínica da fibrose cística / Analysis of modifier genes related to the clinical severity in cystic fibrosis
Introduction: Cystic fibrosis (CF) is clinically manifested in various forms of gravity, modulated by different genotypes and environment. While the classes of mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene are well defined as modulators of severity in CF, polymorphisms remain controversial. Objective: To determine whether p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/08/2011
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10. Enfermidades Cutâneas Digitais Bovina: Aspectos Genéticos E Terapêuticos / Digital dermatitis disease bovine: genetic and therapeutic aspects
This study has aimed do evaluate a risk factor for bovine digital dermatitis and the efficacy of 5% aqueous barbatimão extract solution as ancillary in interdigital skin incisional wound repair. One hundred bovine females, 50 Holstein and 50 Girolando, from two different farms were used for the risk factor study. Experimental units were divided into four gr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/03/2011
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11. HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw
Brazilian Journal of Infectious Diseases. Publicado em: 2010-10
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12. Impact of genetic polymorphism of endothelial nitric oxide synthase on vascular reactivity and adaptation of autonomic modulation to training with physical exercise and diet / Impacto de polimorfismos genéticos da enzima óxido nítrico sintase endotelial sobre as adaptações da reatividade vascular e modulação autonômica a treinamento com exercícios físicos e dieta
Há grande variabilidade inter-individual nas adaptações cardiovasculares a treinamento com exercícios físicos e dieta, provavelmente devido a variações genéticas. Portanto o objetivo geral desta tese foi investigar o impacto de variações no gene da enzima óxido nítrico sintase endotelial (eNOS) sobre adaptações da reatividade vascular e modula�
Publicado em: 2010