Genes Homeobox
Mostrando 25-36 de 353 artigos, teses e dissertações.
-
25. Transcritos do gene PITX1 em carcinomas epidermóides de boca: amplificação por RT-PCR e localização por hibridização in situ. / PITX1 gene transcripts in ora l squamous cell carcinoma: amplification by RT-PCR and localization by in situ hybridization.
Os genes homeobox atuam na morfogênese e na diferenciação celular e vêm sendo relacionados a cânceres em humanos. O projeto Genoma Câncer de Cabeça e Pescoço encontrou aproximadamente 20 desses genes possivelmente envolvidos com esse tipo de neoplasia e o PITX1 foi um dos genes encontrados. Sabe-se que o gene PITX1 está relacionado ao desenvolvi
Publicado em: 2004
-
26. Estudo da expressão dos genes HOXB13 e HHEX em carcinomas epidermóides de boca através das técnicas de RT-PCR e Hibridização in situ. / HOXB13 and HHEX expression study in oral squamous cell carcinoma with the RT-PCR and in situ Hybridization techniques.
The aim of this study was to verify the HOXB13 and HHEX genes expression in oral squamous cell carcinoma (OSCC) using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) and in situ Hybridization techniques. Tumoral tissues and adjacent non-tumoral oral mucosa specimens were obtained from 30 patients with OSCC at the Head and Neck Surgery Service HC (FM
Publicado em: 2004
-
27. Localização dos transcritos dos genes WNT5A e HOXB5 em carcinomas epidermóides de boca através da técnica de hibridização in situ. / WNT5A e HOXB5 localization study in oral squamous cell carcinoma with in situ hybridization.
São freqüentes alterações em vias de sinalização de genes de desenvolvimento, no que diz respeito ao carcinoma epidermóide de boca (CEB). Vinte e nove casos de CEB e tecido não tumoral adjacente à neoplasia foram investigados através da técnica de hibridização in situ. Os transcritos dos genes WNT5A e HOXB5 foram observados em todos os casos
Publicado em: 2004
-
28. Genes homeobox: uma relação molecular entre o desenvolvimento e o câncer
Os genes homeobox são genes reguladores que codificam proteínas nucleares as quais atuam como fatores de transcrição, regulando vários aspectos da morfogênese e da diferenciação celular durante o desenvolvimento embrionário normal de diversos animais. Os genes homeobox de vertebrados podem ser subdivididos em duas famílias: os agrupados, ou HOX, e
Pesquisa Odontológica Brasileira. Publicado em: 2003-03
-
29. Polychaeta, Annelida, and Articulata are not monophyletic: articulating the Metameria (Metazoa, Coelomata)
Polychaetes are metameric worms recognized for having parapodia, chaetae, and nuchal organs. Some authors have extended the Annelida to include Pogonophora, Echiura, and Clitellata. These suggestions are insufficient to generate a monophyletic group. They do not take into account two very large and important clades that in a cladistic analysis at a higher le
Revista Brasileira de Zoologia. Publicado em: 2003-03
-
30. As bases moleculares da leucemia mielóide aguda
A leucemia mielóide aguda (LMA) está freqüentemente associada a translocações cromossômicas recorrentes. Em muitos casos, os genes presentes nos pontos de quebra cromossômica são conhecidos e, quase todos codificam para fatores de transcrição. O gene híbrido, resultante da justaposição de exons de genes distintos, codifica para proteínas de fus
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2002
-
31. Identification of 10 murine homeobox genes.
In Drosophila a number of genes important in establishing segmentation patterns and in determining segment identities have been shown to carry the homeobox sequence. Over 30 murine homeobox genes have been cloned, many on the basis of sequence homology to Drosophila prototypes. Here we report the cloning and sequencing of 10 new and 6 previously known homeob
-
32. Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families.
Homeobox genes are present in both plants and animals. Homeobox-leucine zipper genes, however, have been identified thus far only in the small mustard plant Arabidopsis thaliana. This observation suggests that homeobox-leucine zipper genes evolved after the divergence of plants and animals, perhaps to mediate specific regulatory events. To better understand
-
33. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.
We investigated the role of homeobox-containing genes in human hematopoiesis because homeobox genes (i) control cell fate in the Drosophila embryo, (ii) are expressed in specific patterns in human embryos, and (iii) appear to function as transcription factors that control cell phenotype in other mammalian organs. Using four homeobox probes from the HOX2 locu
-
34. Duplication of large genomic regions during the evolution of vertebrate homeobox genes.
The phylogenetic relationships of 21 murine Antp-class (Drosophila mutation Antennapedia-type class) homeobox genes have been analyzed, and several groups of related genes have been identified. The murine Antp-class homeobox genes are localized within four gene clusters. The similar structural organization of the four gene clusters strongly suggests that gen
-
35. The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution.
The developmental control genes containing an Antennapedia-type homeobox are clustered in insects and vertebrates. The evolution of these genes was studied by the construction of evolutionary trees and by statistical geometry in sequence space. The comparative analysis of the homeobox sequences reveals the subdivision of the Antennapedia-type homeobox genes
-
36. Drosophila NK-homeobox genes.
Four Drosophila melanogaster homeobox genes were found by screening a genomic DNA library with oligodeoxynucleotides that correspond to a conserved amino acid sequence that is part of the putative of homeobox proteins that recognizes nucleotide sequences in DNA. The amino acid sequences of NK-2, NK-3, and NK-4 homeoboxes are more closely related to one anoth