Gene Pon1
Mostrando 13-24 de 44 artigos, teses e dissertações.
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13. Paraoxonase1 gene polymorphisms as predictors of cardiovascular events in stable coronary artery disease / Polimorfismos no gene paraoxonase 1 como preditores de eventos cardiovasculares em pacientes com doença coronária estável
Paraoxonase 1 (PON1) gene polymorphisms have a known relation with lipid metabolism, conferring a marginal and modest effect on serum lipoprotein concentrations and also on development of coronary artery disease (CAD). The primary objective of this study is to investigate the association between PON1 polymorphisms: R192Q- rs662, R160G: rs13306698, Leu55Met:
Publicado em: 2010
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14. Frequency of Q192R and L55M polymorphisms of paraoxonase -1 gene (PON1), A148G and C311S of paraoxonase-2 gene (PON2) in different ethnic groups of brazilian population / Freqüência das mutações Gln192Arg e Leu55Met no gene da paraoxonase 1 e das mutações Ser311Cis e A148G no gene da paraoxonase 2 em brasileiros de diferentes origens étnicas
Paraoxonase (PON) é uma família multigene de enzimas, a qual inclui PON1, PON2 e PON3. Investigações há mais de duas décadas vêm permitindo um melhor conhecimento da função dos genes da paraoxonase, em especial da PON1, no metabolismo de inseticidas organofosforados, lípides oxidados e medicamentos. O principal local de síntese da PON1 é o fígad
Publicado em: 2007
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15. Estudo dos polimorfismos das paraoxonases 1 e 2 em pacientes portadores do vírus da imunodeficiência humana e avaliação do potencial de peroxidação lipídica / Frequency of the Paraoxonase 1 and 2 genetic polymorphisms and analysis of the lipid peroxidation in plasma of HIV positive patients
A paraoxonase sérica humana (PON) vem sendo amplamente estudada. Além da capacidade de PON1 em hidrolisar compostos organofosfatados, sabe-se, atualmente, que toda a família PON (composta por PON1, PON2 e PON3) promove a proteção de lípides, incluindo-se a lipoproteína de baixa densidade (LDL) contra a oxidação. O gene da PON1 sérica apresenta dois
Publicado em: 2007
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16. Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes
Human serum paraoxonase (PON1) is an esterase associated with high density lipoproteins (HDLs) in the plasma and may confer protection against coronary artery disease. Serum PON1 levels and activity vary widely among individuals and populations of different ethnic groups, such variations appearing to be related to two coding region polymorphisms (L55M and Q1
Genetics and Molecular Biology. Publicado em: 2005-03
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17. Inherited thrombophilias among young patients with ischemic stroke
Introdução e Objetivo: A etiologia de acidentes vasculares cerebrais isquêmicos (AVCi) em pacientes jovens permanece desconhecida em um terço dos casos, justificando a procura por novos fatores de risco protrombóticos. Causas comuns de trombofilia hereditária incluem o fator V de Leiden, a mutação G20210A no gene da protrombina, e hiperhomocisteinemi
Publicado em: 2002
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18. Cloning and characterization of the ponA gene encoding penicillin-binding protein 1 from Neisseria gonorrhoeae and Neisseria meningitidis.
The ponA gene encoding penicillin-binding protein 1 (PBP 1) from Neisseria gonorrhoeae was cloned by a reverse genetic approach. PBP 1 was purified from solubilized membranes of penicillin-susceptible strain FA19 by covalent ampicillin affinity chromatography and used to obtain an NH2-terminal amino acid sequence. A degenerate oligonucleotide based on this p
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19. Effects of 5′ Regulatory-Region Polymorphisms on Paraoxonase-Gene (PON1) Expression
Human HDL-associated paraoxonase (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces oxidation of LDLs and HDLs. These properties of PON1 account for its ability to protect against pesticide poisonings and atherosclerosis. PON1 also hydrolyzes a number of lactone and cyclic-carbonate drugs. Among individuals in a population, PON1 leve
The American Society of Human Genetics.
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20. Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism
Human paraoxonase 1 (PON-1) is a serum high-density lipoprotein-associated enzyme mainly secreted by the liver. It has endogenous and exogenous substrates and displays protective properties with respect to cardiovascular disease and organophosphate intoxication. In the HuH7 human hepatoma cell line, PON-1 activity and mRNA levels were increased by dietary po
American Society for Microbiology.
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21. Cloning, nucleotide sequence, and mutagenesis of the Bacillus subtilis ponA operon, which codes for penicillin-binding protein (PBP) 1 and a PBP-related factor.
An oligonucleotide probe designed to hybridize to genes encoding class A high-molecular-weight penicillin-binding proteins (PBPs) was used to identify the ponA gene encoding PBP1a and -1b (PBP1) of Bacillus subtilis. The identity of the ponA product was established by (i) the presence of a sequence coding for a peptide generated from PBP1 and (ii) the disapp
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22. Mutations in ponA, the Gene Encoding Penicillin-Binding Protein 1, and a Novel Locus, penC, Are Required for High-Level Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae
Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonorrhoeae to high-level penicillin resistance have not been cle
American Society for Microbiology.
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23. On the process of cellular division in Escherichia coli: a series of mutants of E. coli altered in the penicillin-binding proteins.
A series of mutants defective in penicillin-binding components (or protein) (PBCs) was isolated from a collection of thermosensitive mutants of Escherichia coli. The mutants included mutations for each PBC (1 through 4) and a mutation in the activity of D-alanine carboxypeptidase 1a (PBC-5/6). PBC-1 was resolved into two components, PBC-1a and PBC-1b, which
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24. Association between the Severity of Angiographic Coronary Artery Disease and Paraoxonase Gene Polymorphisms in the National Heart, Lung, and Blood Institute–Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study
Paraoxonase (PON), a high-density lipoprotein–associated enzyme, is believed to protect against low-density lipoprotein oxidation and thus affects the risk of coronary artery disease (CAD). Three polymorphisms in the PON1 (Leu55Met and Gln192Arg) and PON2 (Ser311Cys) genes have been shown to be associated with the risk of CAD in several European or Europea
The American Society of Human Genetics.