Gene Hoxa10
Mostrando 1-12 de 24 artigos, teses e dissertações.
-
1. Efeitos do Hydrosalpinx no Falho de Implantação Endometrial: Avaliar a salpingectomia nas mulheres em curso de Fertilização in vitro
Abstract Hydrosalpinx is a disease characterized by the obstruction of the salpinx, with progressive accumulation in the shape of a fluid-filled sac at the distal part of the tuba uterina, and closed to the ovary. Women with hydrosalpinges have lower implantation and pregnancy rates due to a combination of mechanical and chemical factors thought to disrupt t
Rev. Bras. Ginecol. Obstet.. Publicado em: 2021-04
-
2. Expressão proteica do gene HOXA10 e dos receptores de estrogênio e progesterona no epitélio, estroma e tecido muscular liso perilesional de endometriose do reto-sigmoide
INTRODUÇÃO: A patogênese da endometriose profunda (EPF) é incerta. O fator de transcrição homeoboxA10 (HOXA10) regula a conferência de identidade tecidual de útero ao ducto paramesonéfrico indiferenciado. HOXA10 é expresso em endometriose ovariana, peritoneal, pulmonar e reto-vaginal, relacionando-o à patogênese da endometriose. Estradiol e proge
Rev. Bras. Ginecol. Obstet.. Publicado em: 2014-08
-
3. Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino / Evaluation of gene expression related to endometrial receptivity in patients undergoing uterine leiomyoma embolization
OBJETIVO: Avaliar a receptividade endometrial de pacientes submetidas à embolização do mioma uterino, analisando a expressão gênica de LIF, IL-11, IL-6, claudina-4, HoxA-10, HoxA-11, receptor de estrogênio e receptor de progesterona antes e após este procedimento. CASUÍSTICA E MÉTODOS: Foram colhidas biópsias aspirativas de endométrio de 30 pacien
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/05/2012
-
4. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.
Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit uterine factor infertility. We have recently demonstrated that HOXA10 is expressed in the adult human uterus. To examine expression of HOXA10 during the menstrual cyc
-
5. Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Diethylstilbestrol (DES) is a nonsteroidal estrogen that induces developmental anomalies of the female reproductive tract. The homeobox gene HOXA10 controls uterine organogenesis, and its expression is altered after in utero DES exposure. We hypothesized that an epigenetic mechanism underlies DES-mediated alterations in HOXA10 expression. We analyzed the exp
The Endocrine Society.
-
6. Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10
HOXA10 is necessary for mammalian reproduction; however, its transcriptional targets are not completely defined. EMX2, a divergent homeobox gene, is necessary for urogenital tract development. In these studies we identify and characterize the regulation of EMX2 by HOXA10. By using Northern analysis and in situ hybridization, we found that EMX2 is expressed i
American Society for Microbiology.
-
7. Hox genes specify vertebral types in the presomitic mesoderm
We show here that expression of Hoxa10 in the presomitic mesoderm is sufficient to confer a Hox group 10 patterning program to the somite, producing vertebrae without ribs, an effect not achieved when Hoxa10 is expressed in the somites. In addition, Hox group 11-dependent vertebral sacralization requires Hoxa11 expression in the presomitic mesoderm, while th
Cold Spring Harbor Laboratory Press.
-
8. p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells
The myeolomonocytic cell line U937 differentiates into macrophages in response to a variety of agents. Several genes including the cyclin-dependent kinase inhibitor p21waf1/cip1 and the homeobox gene transcription factor HOXA10 are induced at the onset of differentiation. Ectopic expression of either gene results in U937 differentiation. In this paper, we de
Cold Spring Harbor Laboratory Press.
-
9. Thrombin and interleukin-1β decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
Bleeding or inflammation in early pregnancy may result in pregnancy loss or defective implantation. Their effect on HOX gene expression in first trimester decidua is unknown. Bleeding results in thrombin generation, although infection or inflammation results in production of cytokines typified by Interleukin-1β (IL-1β). First trimester decidual cells were
Oxford University Press.
-
10. Hoxa 11 is upstream of Integrin α8 expression in the developing kidney
Mutation of the functionally redundant Hoxa 11/Hoxd 11 genes gives absent or rudimentary kidneys resulting from a dramatic reduction of the growth and branching of the ureteric bud. To understand better the molecular mechanisms of Hoxa 11/Hoxd 11 function in kidney development, it is necessary to identify the downstream target genes regulated by their encode
The National Academy of Sciences.
-
11. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
Multiple members of the A, B, and C clusters of Hox genes are expressed in hematopoietic cells. Several of these Hox genes have been found to display distinctive expression patterns, with genes located at the 3' side of the clusters being expressed at their highest levels in the most primitive subpopulation of human CD34+ bone marrow cells and genes located
-
12. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes.
Homeobox genes of the Abdominal B (AbdB) family constitute a distinct subset of vertebrate Hox genes. Analysis of the murine Hoxa-10 gene, one member of this family, revealed several properties specific to this class. Two transcripts of Hoxa-10, a10-1 and a10-2, encode homeodomain proteins of 55 kDa (399 amino acids) and 16 kDa (96 amino acids), respectively