Gene Gba
Mostrando 13-19 de 19 artigos, teses e dissertações.
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13. Nested genetic bit analysis (N-GBA) for mutation detection in the p53 tumor suppressor gene.
There is a growing and significant demand for reliable, simple and sensitive methods for repeated scanning of a given gene or gene fragment for detection and characterization of mutations. Solid-phase sequencing by single base primer extension of nested GBATM primers on miniaturized DNA arrays can be used to effectively scan targeted sequences for missense,
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14. Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes
We wish to identify genes associated with disease. To do so, we look for novel genes whose expression patterns mimic those of known disease-associated genes, using a method we call Guilt-by-Association (GBA), on the basis of a combinatoric measure of association. Using GBA, we have examined the expression of 40,000 human genes in 522 cDNA libraries, and have
Cold Spring Harbor Laboratory Press.
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15. Identification and Confirmation of a Module of Coexpressed Genes
We synthesize a large gene expression data set using dbEST and UniGene. We use guilt-by-association (GBA) to analyze this data set and identify coexpressed genes. One module, or group of genes, was found to be coexpressed mainly in tissue extracted from breast and ovarian cancers, but also found in tissue from lung cancers, brain cancers, and bone marrow. Th
Cold Spring Harbor Laboratory Press.
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16. Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage
Gaucher disease, the most common lysosomal storage disease, is caused by a deficiency of glucocerebrosidase resulting in the impairment of glucosylceramide degradation. The hallmark of the disease is the presence of the Gaucher cell, a macrophage containing much of the stored glucosylceramide found in tissues, which is believed to cause many of the clinical
American Society for Clinical Investigation.
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17. Genome-Wide Expression Analyses of Gene Regulation during Early Development of Dictyostelium discoideum
Using genome-wide microarrays, we recognized 172 genes that are highly expressed at one stage or another during multicellular development of Dictyostelium discoideum. When developed in shaken suspension, 125 of these genes were expressed if the cells were treated with cyclic AMP (cAMP) pulses at 6-min intervals between 2 and 6 h of development followed by hi
American Society for Microbiology.
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18. Genetic Bit Analysis: a solid phase method for typing single nucleotide polymorphisms.
A new method for typing single nucleotide polymorphisms in DNA is described. In this method, specific fragments of genomic DNA containing the polymorphic site(s) are first amplified by the polymerase chain reaction (PCR) using one regular and one phosphorothioate-modified primer. The double-stranded PCR product is rendered single-stranded by treatment with t
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19. Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice
The enterohepatic recirculation of bile acids (BAs) is important in several physiological processes. Although there has been considerable research on liver regeneration after two-thirds partial hepatectomy (PHx), little is known about how the liver protects itself against BA toxicity during regeneration. In this study, various BAs in plasma and liver, the co
American Physiological Society.