Gauchers Disease
Mostrando 1-2 de 2 artigos, teses e dissertações.
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1. Clonagem e expressão da glucocerebrosidase humana em células de ovário de hamster chinês (CHO). / Cloning and expression of human glucocerebrosidase in Chinese hamster ovary (CHO) cells.
Deficiency of the lysosomal glucocerebrosidase (GCR) enzyme results in Gauchers disease. Current treatment consists on enzyme replacement therapy by the administration of recombinant GCR produced in CHO cells. However, the medicine available in the market is extremely expensive. In this work, we proposed the cloning and expression of human GCR in CHO cells,
Publicado em: 2010
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2. Synthesis and Molecular Modeling of Carbohydrate with Potential Anti-glucosidase Activity / Síntese e modelagem molecular de carboidratos com potencial atividade anti-glucosidase
Carbohydrates of glycoconjugates display high degree of complexity and structural diversity, playing a central role in biological processes. Glucosidases are enzymes that catalyze the cleavage of glycosidic bonds in oligosaccharides or glycoconjugates, being essentials in several metabolic pathways and in the biosynthesis of glycoproteins and glycosfingolipi
Publicado em: 2008