Gap Junction
Mostrando 1-12 de 248 artigos, teses e dissertações.
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1. Changes in gap junction proteins Connexin30.2 and Connexin40 expression in the sinoatrial node of rats with dexmedetomidine-induced sinus bradycardia
Abstract Background Dexmedetomidine (Dex) is widely used, and its most common side effect is bradycardia. The complete mechanism through which Dex induces bradycardia has not been elucidated. This research investigates the expression of gap junction proteins Connexin30.2 (Cx30.2) and Connexin40 (Cx40) within the sinoatrial node of rats with Dex-induced sinu
Brazilian Journal of Anesthesiology. Publicado em: 2022
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2. GJB2 c.235delC variant associated with autosomal recessive nonsyndromic hearing loss and auditory neuropathy spectrum disorder
Abstract Autosomal recessive nonsyndromic hearing loss (ARNSHL) is a genetically heterogeneous neurosensory disorder, usually characterized by congenital or prelingual hearing loss. We report a Han Chinese male, born to consanguineous parents, presenting with nonsyndromic sensorineural hearing loss, whose clinical phenotype was also consistent with auditory
Genet. Mol. Biol.. Publicado em: 28/02/2019
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3. Effect of magnesium ion on human osteoblast activity
Magnesium, a promising biodegradable metal, has been reported in several studies to increase bone formation. Although there is some information regarding the concentrations of magnesium ions that affect bone remodeling at a cellular level, little is known about the effect of magnesium ions on cell gap junctions. Therefore, this study aimed to systematically
Braz J Med Biol Res. Publicado em: 04/07/2016
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4. Neuropeptide Y, substance P, and human bone morphogenetic protein 2 stimulate human osteoblast osteogenic activity by enhancing gap junction intercellular communication
Bone homeostasis seems to be controlled by delicate and subtle “cross talk” between the nervous system and “osteo-neuromediators” that control bone remodeling. The purpose of this study was to evaluate the effect of interactions between neuropeptides and human bone morphogenetic protein 2 (hBMP2) on human osteoblasts. We also investigated the effects
Braz J Med Biol Res. Publicado em: 13/02/2015
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5. Emissões otoacústicas evocadas por produto de distorção em frequências ultra-altas em pais de indivíduos com deficiência auditiva autossômica recessiva
Objetivo: Avaliar a função coclear em pais de indivíduos com deficiência auditiva de herança autossômica recessiva do gene Gap Junction Bet-2 Protein por meio das emissões otoacústicas evocadas por produto de distorção (EOA-PD) em frequências ultra-altas, comparando com as respostas de um grupo controle, pareadas por gênero e idade. Métodos
CoDAS. Publicado em: 2014-02
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6. Cochlear function in ultra-high frequencies in parents of individuals with autosomal recessive hearing loss / Função coclear em frequências ultra-altas em pais de indivíduos com deficiência auditiva autossômica recessiva
INTRODUCTION: In nonsyndromic hearing loss of recessive autosomal heritage, caused by changes in the gene GJB2 (Gap Junction Bet-2 Protein), parents of individuals with hearing loss are heterozygous carriers of a recessive allele which causes deafness, however, are asymptomatic, but may present early and mild hearing changes. OBJECTIVE: Assessing the cochlea
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2012
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7. Estudo das propriedades elétricas de células eletroquímicas emissoras de luz de derivados de polifluoreno / Electric properties study of polymer light-emitting electrochemical cells based on polyfluorene derivatives
Polymer light emitting electrochemical cells, PLECs, are organic electronic devices that have attracted commercial interest because they operate at low voltage and exhibit high performance without the need of specific electrodes such as indium tin oxide (ITO), calcium and others. This feature provides low cost of fabrication and exible devices. The charge in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/11/2011
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8. Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-β (TGF-β). This cytokine increases during Trypanosoma cruzi infection, modulating fibrosis and the parasite cell cycle. We studied Cx43 expression in cardiomyocytes exposed or not to TGF-β T. cruzi, or SB-
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
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9. Modulação da expressão de conexinas na retina: um estudo morfológico, bioquímico e funcional. / Modulation of connexin expression in retina: a study using morphological, biochemical and functional approaches.
Life is a dynamic process in time and space, resulting from an interaction provided by gap junctions (GJs), channels composed of connexins (Cxs) that permits the passage of molecules up to 1kDa and ions. The aim of this study was analyze the modulation of Cxs during development, dark adaptation and after local mechanical trauma in the retina using techniques
Publicado em: 2009
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10. Papel da comunicação intercelular midiada pelas junções comunicantes no mecanismo de secreção de insulina em modelos in vivo de maturação e disfunção do pancreas endocrino / Intercellular communication mediated by gap junction in in vivo models of pancreatic B-cell maturation and dysfunction
O objetivo central dessa tese foi estudar o papel das junções comunicantes (GJs) no processo de maturação da célula B e na patogênese da diabetes tipo 2. Para isso, foram utilizados dois modelos animais. No modelo in vivo de maturação da célula B e do processo secretório de insulina foram empregados ratos em vários estágios do desenvolvimento (fe
Publicado em: 2009
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11. Expression of gap junction proteins, the connexins, in normal and neoplastic osseous tissues from dogs / Estudo da expressão das proteínas de junções intercelulares do tipo Gap, as conexinas, em tecido ósseo normal e neoplásico de cães
Increasing evidence indicates that junctional communiction by gap juctions has a critical role in a bone physiology. The main connexin (Cx) express involved in development, differentiation and regulation of tissue growth, is the called Cx43. However, other, two connexis are expressed: Cx45 and Cx46. Cx46 is retained as monomers in a trans-golgi compartment o
Publicado em: 2008
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12. Estudo molecular de genes envolvidos em disturbios de queratinização e perda auditiva / Molecualr study in keratinization disturb and hearing loss genes
Nos organismos superiores, a comunicação entre as células ocorre através de proteínas denominadas conexinas, implicadas na comunicação intercelular (gap junction), as quais permitem a transferência direta de pequenas moléculas e íons. Na pele desempenham um papel crucial na sinalização e diferenciação epidérmica. Na cóclea as gap junctions ex
Publicado em: 2008