Galectins
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Serum galectin-3 levels are decreased in schizophrenia
Objective: To determine whether changes in serum galectin-3 (gal-3) concentrations in schizophrenia patients have etiopathogenetic importance. Since very little research has assessed the connection between galectins and schizophrenia, we wanted to examine alterations in the inflammatory marker gal-3 in schizophrenia and investigate possible correlations bet
Braz. J. Psychiatry. Publicado em: 2020-08
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2. Deep sequencing analysis of toad Rhinella schneideri skin glands and partial biochemical characterization of its cutaneous secretion
Abstract Background: Animal poisons and venoms are sources of biomolecules naturally selected. Rhinella schneideri toads are widespread in the whole Brazilian territory and they have poison glands and mucous gland. Recently, protein from toads’ secretion has gaining attention. Frog skin is widely known to present great number of host defense peptides and
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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3. Avaliação imuno-histoquímica das galectinas -1, -3 e -7 em displasia epitelial ora
Introdução: A displasia epitelial oral (DEO) é uma lesão potencialmente maligna, cujo diagnóstico e gradação se baseia na histologia das alterações arquiteturais e citológicas, preconizados pela OMS, que divide a lesão em leve, moderada e severa, o qual é subjetivo. Maior concordância é observada no uso do sistema binário (baixo/alto risco), o
Publicado em: 2010
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4. Clonagem, expressão, purificação e estudos estruturais dos domínios de reconhecimento de carboidratos (CRDs) da galectina-4 humana / Cloning, expression, purification and structural studies of the carbohydrate-recognition domains (CRDs) of human galectin-4
The galectin family comprises a group of lectins where the carbohydrate-recognition domains (CRDs) display specific affinity for ß-galactosides. They are widely distributed in normal and neoplasic cells of different organisms and are involved in a great diversity of cellular mechanisms. The galectins have been focus of recent studies, mainly for their invol
Publicado em: 2009
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5. Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua.
Diversos estudos são desenvolvidos com o intuito de se estabelecer parâmetros para determinar o comportamento biológico do carcinoma epidermóide oral, tendo em vista que esta neoplasia apresenta altas taxas de morbidade e mortalidade. O objetivo do presente trabalho foi realizar uma análise clínica, morfológica e imuno-histoquímica através da expres
Publicado em: 2009
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6. Avaliação do papel da galectina-3 sobre funções de neutrófilos durante a infecção por cepa virulenta RH de Toxoplasma gondii em camundongos C57BL/6
Galectins are beta-galactoside-binding animal lectins involved in several biological processes, and Gal-3 has been related to modulation of immune reactions and inflammatory responses. The present study aimed to evaluate the influence of Gal-3 in neutrophil viability, early apoptosis and cell death in parallel with its biological functions after in vivo and
Publicado em: 2009
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7. Isolation of a ß-galactoside-binding lectin from cat liver
A lectin from cat liver has been identified and purified by affinity chromatography on asialofetuin-Sepharose. One hundred micrograms of lectin was obtained from one cat liver with a purification factor of 1561. The lectin agglutinates trypsin-treated rabbit and cow erythrocytes. Hemagglutination was inhibited only by saccharides containing ß-galactosyl res
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-04
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8. Evidence for a role for galectin-1 in pre-mRNA splicing.
Galectins are a family of beta-galactoside-binding proteins that contain characteristic amino acid sequences in the carbohydrate recognition domain (CRD) of the polypeptide. The polypeptide of galectin-1 contains a single domain, the CRD. The polypeptide of galectin-3 has two domains, a carboxyl-terminal CRD fused onto a proline- and glycine-rich amino-termi
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9. A Caenorhabditis elegans Glycolipid-binding Galectin Functions in Host Defense against Bacterial Infection*
Galectins are a family of β-galactoside-binding proteins that are widely found among animal species and that regulate diverse biological phenomena. To study the biological function of glycolipid-binding galectins, we purified recombinant Caenorhabditis elegans galectins (LEC-1–11) and studied their binding to C. elegans glycolipids. We found that LEC-8 bi
American Society for Biochemistry and Molecular Biology.
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10. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins
Here we describe a glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide. The array comprises 200 synthetic and natural glycan sequences representing major glycan structures of glycoproteins and glycolipids. The array has remarkable utility for profiling
National Academy of Sciences.
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11. Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm
Secretions of the uterus support survival and growth of the conceptus (embryo/fetus and associated membranes) during pregnancy. Galectin-15, also known as OVGAL11 and a previously uncharacterized member of the galectin family of secreted β-galactoside lectins containing a conserved carbohydrate recognition domain and a separate putative integrin binding dom
National Academy of Sciences.
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12. The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site
Cell attachment and membrane penetration are functions of the rotavirus outer capsid spike protein, VP4. An activating tryptic cleavage of VP4 produces the N-terminal fragment, VP8*, which is the viral hemagglutinin and an important target of neutralizing antibodies. We have determined, by X-ray crystallography, the atomic structure of the VP8* core bound to
Oxford University Press.