Galectin 3
Mostrando 13-24 de 48 artigos, teses e dissertações.
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13. A expressão galectina-3 como marcador de malignidade de neoplasias de tireóide
Fine needle aspiration biopsy is considered to be the best propedeutic method used in evaluation of a thyroid nodule. However, in some situations, it is impossible to cytologically distinguish a malignant and a begnin disease; therefore, surgeons must indicate thyroidectomy for a diagnostic purpose. This results that most suspect nodules are referred to surg
Publicado em: 2008
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14. A galectina-3 na fisiologia e no câncer de tiróide: identificação de SNPs no gene LGALS3 e estudo funcional de galectina-3 in vitro e in vivo / Galectin-3 in thyroid physiology and cancer: identification of SNPs in the LGALS3 gene and functional study of galectin-3 in vitro and in vivo.
Neste estudo, investigamos o envolvimento de galectina-3 na fisiologia e no câncer de tiróide usando vários modelos biológicos e metodologias. Observamos que o gene LGALS3 apresenta um SNP no códon 98, mas não observamos correlação entre os genótipos deste SNP e fenótipo de câncer de tiróide. Na linhagem de tiróide de rato PCCl3, mostramos que a
Publicado em: 2008
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15. Study of the interaction between Gal-1 and mast cell / Estudo da interação de galectina-1 e mastócitos
Galectin-1 (Gal-1) belongs to a family of ?-galactoside-binding proteins and is involved in several biological processes, including modulation of the inflammatory response. Mast cells play a critical role in allergic and inflammatory events, however, little is known about the impact of Gal-1 on mast cell biology. In this study, we examined the role of Gal-1
Publicado em: 2008
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16. Estudo da expressão imunoistoquímica da proteína galectina-3 associada à -catenina e ciclina D1 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares / Differential expression of galectin-3, -catenin and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands
Neoplasias malignas das glândulas salivares são lesões raras e o mecanismo pelo qual esses tumores progridem ainda não está completamente esclarecido na literatura. A galectina-3 é uma proteína multifuncional expressa em uma grande quantidade de tecidos normais, mas que também tem sido associada à progressão tumoral de neoplasias malignas da tireó
Publicado em: 2008
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17. AnÃlise histolÃgica e histoquÃmica de fatores prognÃsticos em pacientes com retocolite ulcerativa
Nos Ãltimos anos tem se aumentado o interesse pelo estudo cada vez mais detalhado dos processos patolÃgicos envolvidos nas doenÃas inflamatÃrias intestinais, em especial a retocolite ulcerativa idiopÃtica. Visando oferecer um mÃtodo que auxilie o diagnÃstico diferencial ou mesmo que seja indicador da transformaÃÃo neoplÃsica, a galectina-3 surge co
Publicado em: 2008
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18. Evidence for a dual role of galectin-3 in murine melanoma growth / Evidência da dualidade funcional de galectina-3 no crescimento de melanoma murino
Tumors have been described as microenvironments composed not only by malignant cells, but also by endothelial cells, fibroblasts and leukocytes, which can promote tumor growth and angiogenesis. Galectin-3, a b-galactoside binding protein, is expressed by monocytes/macrophages and others leukocytes. In fact, several lines of evidence suggest that galectin-3 a
Publicado em: 2007
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19. Mecanismos associados à perda de expressão do gene de galectina-3 em um modelo de progressão de melanoma murino / Mechanisms associated to the loss of galectin-3 gene expression in a model of murine melanoma progression
Galectin-3 is a b-galactoside-binding animal lectin, shown to be involved in tumor progression and metastasis. Galectin-3 expression has been found altered along tumor progression of different tumors. In some types of cancers such as thyroid carcinoma and bladder carcinoma, galectin-3 expression has been found increased, whereas in tumors such as breast carc
Publicado em: 2007
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20. Contribution of the cellular nucleus texture analyses for the differential diagnosis of follicular thyroid lesions: comparison with imunohistochemical / Contribuição da analise de textura do nucleo celular para o diagnostico diferencial de lesões foliculares da tireoide : comparação com marcadores imunoistoquimicos
The differential diagnosis between some thyroid lesions is often difficult to determine, even with permanent sections. The purpose of this study was to find out if chromatin texture analysis contributes to the differential diagnosis of thyroid follicular lesions. We selected slides stained with H-E (hematoxilin-eosin) of 12 hyperplastic adenomatous nodules (
Publicado em: 2007
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21. "Predição do risco de metástase do carcinoma bem diferenciado da glândula tireóide pela quantificação digital da imunoexpressão da galectina-3 nos compartimentos do tireócito maligno" / Prediction of metastasis risk in well-differentiated thyroid carcinoma based on digital quantification of galectin-3 immunoexpression in subcellular compartments of the malignant thyrocyte
INTRODUCTON: Papillary and follicular carcinomas are primary malignant neoplasias of the thyroid gland and are classified as well-differentiated carcinoma. In these cases, determination of individual risk of metastasis allows offering an adequate treatment. Nowadays therapy is chosen based on classification according to prognostic factors and biomarkers can
Publicado em: 2006
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22. Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands / "Expressão imunoistoquímica da proteína galectina-3 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares"
Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma are malignant neoplasms of salivary glands which are similar in histologic patterns but very different in clinical behavior, treatment and prognosis. Galectin-3 is a multifunctional protein of a growing family of beta-galactoside-binding animal lectins which is implicated in a variety of biol
Publicado em: 2006
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23. Human Galectin-3 Promotes Trypanosoma cruzi Adhesion to Human Coronary Artery Smooth Muscle Cells
Human galectin-3 binds to the surface of Trypanosoma cruzi trypomastigotes and human coronary artery smooth muscle (CASM) cells. CASM cells express galectin-3 on their surface and secrete it. Exogenous galectin-3 increased the binding of T. cruzi to CASM cells. Trypanosome binding to CASM cells was enhanced when either T. cruzi or CASM cells were preincubate
American Society for Microbiology.
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24. Evidence for a role for galectin-1 in pre-mRNA splicing.
Galectins are a family of beta-galactoside-binding proteins that contain characteristic amino acid sequences in the carbohydrate recognition domain (CRD) of the polypeptide. The polypeptide of galectin-1 contains a single domain, the CRD. The polypeptide of galectin-3 has two domains, a carboxyl-terminal CRD fused onto a proline- and glycine-rich amino-termi