Gag
Mostrando 1-12 de 2529 artigos, teses e dissertações.
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1. Clinical and Microbiological Evaluation of Surgical and Nonsurgical Treatment of Aggressive Periodontitis
Resumo O presente estudo teve como objetivo avaliar os efeitos clínicos e microbiológicos de terapia periodontal cirúrgica e não cirúrgica no tratamento da periodontite agressiva generalizada (PAgG). Dezesseis pacientes portadores de PAgG foram incluídos neste estudo clínico, prospectivo, randomizado, de boca dividida. Os quadrantes superiores de cada
Braz. Dent. J.. Publicado em: 28/11/2019
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2. Urinary Glycosaminoglycan Electrophoresis With Optimized Keratan Sulfate Separation Using Peltier System for the Screening of Mucopolysaccharidoses
Abstract The purpose of this communication is to indicate a simple and rapid method with a small volume of urine sample to detect urine glycosaminoglycan (GAG) and serve as a screening procedure for mucopolysaccharidoses (MPSs). Total GAG measurement for patients with MPS disorders is considered to be the first step in diagnosis of those heterogeneous group
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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3. A Cerebrospinal Fluid Collection Study in Pediatric and Adult Patients With Hunter Syndrome
Abstract Hunter syndrome (mucopolysaccharidosis II [MPS II]) is characterized by lysosomal glycosaminoglycan (GAG) accumulation. Although a majority of patients with MPS II experience neurocognitive involvement, few data are available on cerebrospinal fluid (CSF) GAG levels in these patients. This study measured GAG levels in CSF collected from 9 patients wi
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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4. Enzyme Replacement Therapy With Elosulfase Alfa Decreases Storage of Glycosaminoglycan in White Blood Cells of Patients With Morquio A Syndrome
Abstract Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by a deficient N-acetylgalactosamine-6-sulfate sulfatase activity, leading to cellular storage of undegraded keratan sulfate. Recently enzyme replacement therapy (ERT) was approved for MPS IVA, but some of ERT effects are still unknown. In the present stud
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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5. CASE SERIES OF PATIENTS UNDER BIWEEKLY TREATMENT WITH LARONIDASE: A REPORT OF A SINGLE CENTER EXPERIENCE
RESUMO Objetivo: Descrever a manutenção dos níveis de glicosaminoglicano (GAG) excretados na urina e da estabilização clínica em pacientes com mucopolissacaridose do tipo I (MPS I) com o uso da laronidase num regime de dose alternativo de 1,2 mg/kg a cada duas semanas. Método: Alguns pacientes do nosso serviço participaram de um estudo de otimiza
Rev. paul. pediatr.. Publicado em: 09/05/2019
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6. Macrophage migration inhibitory factor antagonist (p425) ameliorates kidney histopathological and functional changes in diabetic rats
Resumo Introdução: Supõe-se que elevações da expressão do fator de inibição da migração de macrófagos (MIF) possam contribuir para a patogênese da nefropatia diabética (ND). O objetivo do presente estudo foi investigar os efeitos renais da inibição do MIF em um modelo experimental diabético. Métodos: Dezoito ratos Wistar machos (230 ± 20g
J. Bras. Nefrol.. Publicado em: 24/01/2019
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7. Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3′-untranslated region
The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3′-untranslated region (3′-UTR). Different PR (rs689465, rs689466, rs20417) and 3′-UTR
Braz J Med Biol Res. Publicado em: 30/11/2017
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8. Propriedades antioxidante e antimicrobiana de extratos etanólicos de guaraná, boldo, alecrim e canela
Resumo Nesta investigação, foram estudados dois extratos etanólicos de plantas pouco conhecidas na literatura (guaraná e boldo-do-chile), em comparação com os extratos etanólicos de duas plantas bastante estudadas (canela e alecrim), quanto aos parâmetros de cor, perfil GC-MS, teor fenólico e propriedades antioxidantes e antimicrobianas. Os extratos
Braz. J. Food Technol.. Publicado em: 08/06/2017
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9. An overview of the molecular and epidemiological features of HIV-1 infection in two major cities of Bahia state, Brazil
BACKGROUND The high mutation rate of the human immunodeficiency virus (HIV) has created a public health challenge because the use of antiretroviral drugs can generate selective pressure that drives resistance in these viruses. OBJECTIVE The aim of this work was to characterise the molecular and epidemiological profile of HIV in Bahia, Brazil. METHODS D
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-06
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10. Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis
Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and pathways in OS utilizing EgoNet algorithm and pathway-r
Braz J Med Biol Res. Publicado em: 16/02/2017
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11. IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters
Abstract Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin(IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical
Braz. oral res.. Publicado em: 16/01/2017
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12. Use of a commercial agarose gel for analysis of urinary glycosaminoglycans in mucopolysaccharidoses
ABSTRACT Mucopolysaccharidoses (MPS) are a group of inherited metabolic disorders caused by deficiency of enzymes that degrade glycosaminoglycans (GAGs). Urinary excretion of GAGs is a common feature of MPS, and is considered their major biomarker. We aimed to adapt the GAG electrophoresis method to a commercial agarose gel which would be able to separate ur
Braz. J. Pharm. Sci.. Publicado em: 2016-12