G Protein Coupled Receptors
Mostrando 1-12 de 654 artigos, teses e dissertações.
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1. The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, a
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-01
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2. G-protein activation revealed by [35S]-GTPγS binding assay is involved on the antidepressant-like effect of Hyperi cum caprifoliatum and Hypericum polyanthemumcyclohexane extracts
AbstractPrevious studies by us demonstrated the antidepressant-like and antinociceptive effects of lipophilic extracts and dimeric acyl-phloroglucinols from species of the genus Hypericum native to Southern Brazil. Uliginosin B and HC1 (an enriched phloroglucinol fraction from Hypericum caprifoliatum) are able to inhibit monoamine synaptosomal uptake without
Rev. bras. farmacogn.. Publicado em: 2015-08
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3. Identificação de receptores moleculares para ligantes detectados pelo Órgão Vomeronasal / Identification of molecular receptors for ligands detected by the Vomeronasal Organ
Uma propriedade fundamental do sistema nervoso em todas as espécies animais e a transformação dos estímulos sensoriais em atividade neural, levando a mudanças comportamentais e endócrinas. Dentre os sistemas sensoriais, o Sistema Olfatório destaca-se por sua complexidade molecular, capacidade de detecção de odores e modulação de comportamentos ina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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4. The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line
The success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia. The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neo-intimal hyperplasia, and a role for angiotensin II in vascular smooth muscle cell proliferation has been propos
Brazilian Archives of Biology and Technology. Publicado em: 2012-04
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5. Vias de sinalização intracelular envolvidas no efeito proliferativo de relaxina em células de sertoli / Intracelular signaling pathways involved in the proliferative effect of relaxin in rat Sertoli cells
Relaxin is an insulin-related peptide that activates the G-protein coupled receptor RXFP1. Although relaxin plays an important role in female reproduction its physiological role in the male reproductive system is still unclear. We have previously demonstrated that relaxin and RXFP1 are expressed in testis (FILONZI et al., 2007; CARDOSO et al., 2010). Both re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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6. Search for a platelet-activating factor receptor in the Trypanosoma cruzi proteome: a potential target for Chagas disease chemotherapy
Chagas disease (CD) causes the highest burden of parasitic diseases in the Western Hemisphere and is therefore a priority for drug research and development. Platelet-activating factor (PAF) causes the CD parasite Trypanosoma cruzi to differentiate, which suggests that the parasite may express PAF receptors. Here, we explored the T. cruzi proteome for PAF rec
Mem. Inst. Oswaldo Cruz. Publicado em: 2011-12
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7. Papel dos canais K+ATP na resposta eletrofisiológica ao FSH e ao isoproterenol em células de Sertoli
Follicle-stimulating hormone (FSH) produces a dual effect on the membrane potential of Sertoli cells, with an initial rapid phase, which comprises a hyperpolarization for a period of seconds and a depolarization phase, wich occurs more slowly, within minutes. The depolarization phase involves calcium entry stimulated by FSH. Isoproterenol, an agonist of ¿-a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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8. Papel dos receptores B1 e B2 de bradicinina e de captopril nas interações célula hospedeira-Trypanosoma cruzi
The infection of monocytes by Trypanosoma cruzi tripomastigotes is a crucial step for the development of Chagas disease immune response. Infection by T. cruzi has demonstrated to be an active process, involving diverse cellular components and different cell types. Previous studies of the interaction tissue-culture derived trypomastigotes (TCT) between cardio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/08/2010
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9. Estudo da modelagem molecular do receptor canabinóide CB1 e suas interações com o ∆9 - THC / Molecular modeling study of CB1 cannabinoid receptor and its interaction with delta-9-THC
Marijuana (Cannabis sativa) is a widely used plant and its various applications have important benefits. The plant Cannabis sativa has been used by man for centuries for eating, medicinal practices and religious rituals. In human subjects, its effects include analgesia, alterations in perceptions, cognition, memory and psychomotor activity. The cannabinoid c
Publicado em: 2009
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10. Melatonin effect on the endothelial nitric oxide production in vitro and in vivo / Efeito da melatonina sobre a produção endotelial de óxido nítrico in vitro e in vivo
Melatonin, the darkness hormone, produced at night by the pineal gland, is also synthesized in a non-rhythmic manner by other cells. Pineal and extra-pineal melatonin reaches endothelial layer, and the understanding of its mechanism of action will improve the possibilities of using this indolamine and derivates as pharmacological tools. Here we showed that m
Publicado em: 2009
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11. Purinergic signalling: past, present and future
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's. The concept of purinergic cotransmission was formulated in 1976 and it is now recognized that ATP is a cotransmitter i
Brazilian Journal of Medical and Biological Research. Publicado em: 03/10/2008
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12. ClassificaÃÃo de proteÃnas usando mÃquinas de aprendizagem e descoberta de padrÃes / Classification of proteins using machines learning and pattern discovery
Machines learning have been applied in several different problems in bioinformatics. Similarly, pattern discovery algorithms have also been used to discovery motifs in protein sequences, contributing to define signatures (such as fingerprints) that describes function classes of proteins. For instance, the G-protein coupled receptors (GPCRs) class represents
Publicado em: 2008