Furan Analogues
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Síntese e avaliação da atividade fitotóxica de compostos heteroaromáticos análogos aos nostoclídeos / Synthesis and phytotoxic activity evaluation of heteroaromatic nostoclide analogues
Os nostoclídeos I e II foram isolados de uma alga verde-azul Nostoc sp, presente no líquen Peltigera canina. Estes compostos são estruturalmente semelhantes à cianobacterina que possui atividade fitotóxica, inibindo o transporte de elétrons no fotossistema II da fotossíntese. Alguns compostos análogos aos nostoclídeos também possuem atividade fitot
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2011
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2. Sintese e atividade biologica de analogos furanicos da goniotalamina / Synthesis and biological activity of furan analogues of goniothalamin
This work describes the preparation of furan analogues of goniothalamin (compounds 31, 32 and 33) in both enantiomeric forms through the utilization of Keck asymmetric allylation and ring-closing methatesis reaction. These analogues were prepared in good overall yield and excellent enantiomeric ratio. These novel compounds were evaluated as antiproliferative
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2009
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3. Síntese e avaliação das atividades fitotóxicas e citotóxicas de compostos análogos aos nostoclídeos
The nostoclides are produced by a cyanobacterium Nostoc sp. symbiont of Peltigera canina, and belong to a family of compounds know as -alkylidenebutenolides. Nostoclides have been shown to have moderate cytotoxicity against the mouse neuroblastoma cell lines Neuro-2a CCL and KB CCL 17. Due to the fact that Peltigera canina cultures are usually not contaminat
Publicado em: 2008
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4. Synthesis and Evaluation of the Phytotoxicity of News Butenolides Analogues of the Nostoclides. / Síntese e avaliação da fitotoxicidade de novos butenolídeos análogos aos nostoclídeos
The nostoclides belong to a class of natural compounds called γ-alkylidenebutenolides that have several representatives with biological application. To contribute to the study of this class of compounds, this present work aimed to synthesize new butenolides analogous to the nostoclides from furan-2 (5H)-one [8] and evaluate the phytotoxic activity of th
Publicado em: 2007
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5. Reactivity with DNA of three pyrenofuran analogues of benzo(a)pyrene and benzo(e)pyrene.
Three pyrenofurans, the pyreno[1,2-b]furan (FP1), the pyreno[2,1-b] furan (FP2) and the pyreno[4,5-b]furan (FP3) have been synthesized as analogues of the mutagenic and carcinogenic benzo(a)pyrene (FP1 and FP2) and of its non-carcinogenic isomer benzo(e)pyrene (FP3). For each of the pyrenofurans, the reactivity with DNA has been tested in presence of liver m