Functional Genomics
Mostrando 1-12 de 338 artigos, teses e dissertações.
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1. The impact of pre-existing thyroid diseases on susceptibility to respiratory infections or self-reported sickness during the SARS-CoV-2 pandemic
ABSTRACT Introduction: This study aimed to evaluate the incidence, severity and presence of symptoms of respiratory tract infections and COVID-19, in patients with pre-existing thyroid dysfunction compared to individuals without thyroid diseases, during the peak month of the COVID-19 pandemic in the Netherlands. Subjects and methods: In this retrospective
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Exploration of gene functions for esophageal squamous cell carcinoma using network-based guilt by association principle
Gene networks have been broadly used to predict gene functions based on guilt by association (GBA) principle. Thus, in order to better understand the molecular mechanisms of esophageal squamous cell carcinoma (ESCC), our study was designed to use a network-based GBA method to identify the optimal gene functions for ESCC. To identify genomic bio-signatures fo
Braz J Med Biol Res. Publicado em: 19/04/2018
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3. Efficient In Vitro Somatic Embryogenesis and Plant Regeneration from Mature and Immature Embryos of Wheat ( Triticum aestivum L.)
ABSTRACT An efficient regeneration system is a pre-requisite for the application of genetic transformation and functional genomics study of important plants. In this study, the effect of different factors (plant growth regulators, casein hydrolysate, aspartic acid and ascorbic acid) on in vitro embryogenesis and regeneration of Arta, Bahar and Zagros cultiva
Braz. arch. biol. technol.. Publicado em: 08/01/2018
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4. The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, a
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-01
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5. Comparative genomics of an endophytic Pseudomonas putida isolated from mango orchard
Abstract We analyzed the genome sequence of an endophytic bacterial strain Pseudomonas putida TJI51 isolated from mango bark tissues. Next generation DNA sequencing and short read de novo assembly generated the 5,805,096 bp draft genome of P. putida TJI51. Out of 6,036 protein coding genes in P. putida TJI51 sequences, 4,367 (72%) were annotated with functio
Genet. Mol. Biol.. Publicado em: 07/07/2016
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6. Identification of selection signatures in livestock species
The identification of regions that have undergone selection is one of the principal goals of theoretical and applied evolutionary genetics. Such studies can also provide information about the evolutionary processes involved in shaping genomes, as well as physical and functional information about genes/genomic regions. Domestication followed by breed formatio
Genet. Mol. Biol.. Publicado em: 2014-06
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7. Effects of BST and high energy diet on gene expression in mammary parenchyma of dairy heifers
The objective of this study was to determine the effects of dietary energy and recombinant bovine somatotropin (bST) injection to identify genes that might control mammogenesis. Total RNA was extracted from the parenchymal tissue of 32 heifers randomly assigned to one of four treatments: two diets (a standard diet and a high energy, high protein diet), each
R. Bras. Zootec.. Publicado em: 2013-07
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8. Trypanosomatid comparative genomics: contributions to the study of parasite biology and different parasitic diseases
In 2005, draft sequences of the genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, also known as the Tri-Tryp genomes, were published. These protozoan parasites are the causative agents of three distinct insect-borne diseases, namely sleeping sickness, Chagas disease and leishmaniasis, all with a worldwide distribution. Despite the large
Genetics and Molecular Biology. Publicado em: 20/01/2012
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9. Personalized medicine: caught between hope, hype and the real world
Genomic and personalized medicine have become buzz phrases that pervade all fields of medicine. Rapid advances in "-omics" fields of research (chief of which are genomics, proteinomics, and epigenomics) over the last few years have allowed us to dissect the molecular signatures and functional pathways that underlie disease initiation and progression and to i
Clinics. Publicado em: 2012
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10. Análise do microtranscritoma em variedades de cana-de-açúcar (Saccharum spp.) submetidas a estresse hídrico / Microtranscriptome analysis of sugarcane (Saccharum spp.) cultivars under drought stress
Sugarcane (Saccharum spp.) is amongst the most relevant crops in the world and Brazil is the most prominent producer. It is an inexpensive and efficient source for commodities such as sugar and ethanol, the latter being increasingly considered the most promising immediate energy source substitute for oil, mainly in transportation. Apart from being very produ
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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11. Mecanismos intraflagelares de transporte e trânsito de proteínas: uma abordagem pós-genômica e computacional de caracterização da virulência flagelar em Leishmania spp. / Intraflagelares mechanisms of transport and transit proteins: a post-genomics and computational characterization of virulence flagellar Leishmania spp.
Leishmania are flagellated protozoa that cause a main neglected diseasease, collectively known as leishmaniases, posing a constant challenge for the control and prevention of the disease due to the wide-world distribution and prevalence of these parasites. As an insinuating pathogen, Leishmania has a specialized organelle for motility, the flagellum, which i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/01/2011
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12. Overexpression of kermit/dGIPC is associated with lethality in Drosophila melanogaster
Insertional mutagenesis is an important tool for functional genomics in Drosophila melanogaster. The insertion site in the KG00562 mutant fly line has been mapped to the CG8709 (herein named DmLpin) locus and to the 3’ of kermit (also called dGIPC). This mutant line presents a high lethality rate resulting from a gain of function. To obtain some insight in
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04