Franz Cell
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles
To improve 17-α-estradiol targeting in alopecia treatment, a formulation of nanostructured lipid carrier (NLC) prepared by the sonication method was developed. The physicochemical characterization showed an average diameter of 96 ± 15 nm and the average zeta potential of -17 ± 6 mV. In addition, the encapsulation efficiency (EE) of 17-α-estradiol, assess
J. Braz. Chem. Soc.. Publicado em: 2020-07
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2. Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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3. A smart approach for delivery of aripiprazole via oro-soft palatal mucosal route for improved therapeutic efficacy
Effective management of schizophrenia, acute mania, mixed episodes associated with bipolar disorders, and depression can be managed with aripiprazole moiety. In the present research work an attempt was made to minimize the dose related side effects thus improving the quality life of the patients. A novel biopolymer was isolated from the fruits of Trachysperm
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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4. Effect of pH on weakly acidic and basic model drugs and determination of their ex vivo transdermal permeation routes
ABSTRACT The aim of the present study was to investigate the effect of donor pH on the transdermal permeability of the model drugs across rat skin and also to determine the major route of transport of the drugs. Weakly acidic drugs (partition coefficient) ibuprofen (3.6), aceclofenac (3.9), glipizide (1.9) and weakly basic drugs olanzapine (3.6), telmisartan
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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5. Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equatio
An. Acad. Bras. Ciênc.. Publicado em: 01/12/2016
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6. Sunitinib treatment in patients with advanced renal cell cancer: the Brazilian National Cancer Institute (INCA) experience
ABSTRACT Purpose: The aim of this study was to assess the impact of sunitinib treatment in a non-screened group of patients with metastatic renal cell cancer (mRCC) treated by the Brazilian Unified Health System (SUS) at a single reference institution. Material and Methods: Retrospective cohort study, which evaluated patients with mRCC who received sunitin
Int. braz j urol.. Publicado em: 2016-08
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7. Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
AbstractA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films w
Polímeros. Publicado em: 2015-08
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8. Metodologia analítica aplicada ao controle de qualidade do antifúngico cloridrato de butenafina na forma de creme e à avaliação da sua penetração cutânea in vitro / Analytical methodology applied to the quality control of the antifungal butenafine hydrochloride in cream formulation and to the analysis of its penetration in vitro
Objectives: The aim of the present work was to develop, validate and compare stability indicating methods to quantify butenafine hydrochloride (BTF), raw material and commercial cream, as well as to establish the degradation kinetics of the drug in a stress condition. Also, the study had the goal of validating a method to assess and compare the cutaneous per
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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9. Avaliação in vitro da atividade antitumoral de compostos de coordenação de ferro
Neoplasias are the third leading cause of death in Brazil and death by cancer is estimated to reach the most important death cause in Brazil at the middle of this century. Nowadays cancer causes nearly 7 million deaths every year (12.5%) worldwide, although several cancer therapies are available. In this work we studied the antitumoral activity of three iron
Publicado em: 2008
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10. Phase II trial of neoadjuvant gemcitabine and cisplatin in patients with resectable bladder carcinoma
OBJECTIVES: Gemcitabine and cisplatin (GC) is an active combination in the treatment of metastatic bladder cancer. We have prospectively analyzed the efficacy and tolerability of GC as neoadjuvant treatment of invasive bladder cancer MATERIALS AND METHODS: In this single-institution phase II trial, patients with muscle-invasive transitional cell carcinoma re
International braz j urol. Publicado em: 2007-10
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11. Associação da isoflavona genisteína com beta-ciclodextrina : avaliação da penetração cutânea / Association of genistein with β-cyclodextrin : skin penetration evaluation
A genisteína é uma isoflavona da soja que vem sendo investigada pelo seu potencial antienvelhecimento, baseado nas suas atividades antioxidante, estrogênica e inibidora de proteínas tirosina-quinase. A associação da genisteína com β- ciclodextrina com a formação de um complexo elevou a hidrossolubilidade da isoflavona. A permeabilidade intrínseca
Publicado em: 2007
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12. Revestimento de stents com filmes de PVA eluidores de S-nitrosoglutationa / Stents coating with S-nitrosoglutathione-eluting poly (vynyl alcohol) films
Stents are expansible wire mesh tubes used in angioplasty procedures in order to widening the luminal diameter of the coronary arteries. There is currently a great interest in the development of stents coated with drug-eluting polymeric matrices, which are able to prevent future closure of artery (restenosis). S-nitrosothiols which are nitric oxide (NO) dono
Publicado em: 2006