Forced Swimming Test
Mostrando 13-24 de 38 artigos, teses e dissertações.
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13. Antidepressivos modificam a extinção de uma memória aversiva em ratas
Treatment of major depression, posttraumatic stress disorder and other psychopathologies with antidepressants can be associated with improvement of the cognitive deficits related to these disorders. Although the mechanisms of these effects are not completely elucidated, alterations in extinction of aversive memories are believed to be present in these psycho
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/05/2011
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14. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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15. Biological activities of Juglans regia flowers
Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both mo
Revista Brasileira de Farmacognosia. Publicado em: 03/06/2011
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16. Anxiolytic-like and sedative effects of Hydrocotyle umbellata L., Araliaceae, extract in mice
The plant Hydrocotyle umbellata L., Araliaceae (water pennywort), is widely used in Brazilian folk medicine to reduce anxiety. This work investigates the anxiolytic-like effects of the ethanol extract from H. umbellata subterraneous parts as well as the extract's other putative central nervous system effects that could justify its common use. Oral dosing of
Revista Brasileira de Farmacognosia. Publicado em: 25/02/2011
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17. Efeitos a longo prazo de diferentes separações dos filhotes no período neonatal sobre as genitoras
Esse estudo foi realizado para verificar se a exposição a separações repetidas (por diferentes intervalos de tempo) de mães dos seus filhotes no período neonatal poderiam ser classificadas como indutoras de um estado do tipo deprimido em genitoras. Sessenta ratas Wistar prenhes foram divididas em 3 grupos: controle, separação por 10 minutos e separa�
Publicado em: 2011
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18. EFEITOS AGUDOS DA ASSOCIAÇÃO DE ETANOL E AMINOFILINA EM TESTES COMPORTAMENTAIS E NEUROQUÍMICOS EM CAMUNDONGOS / ACUTE EFFECTS OF ETHANOL AND ASSOCIATION TESTS IN aminophylline behavioral and neurochemical IN MICE
Ethanol effects in central nervous system (CNS) are due to its action in several neurotransmitter systems, changing the existing balance in inhibitory and excitatory pathways. Aminophylline, a methylxanthine with stimulant action, is an adenosine receptor antagonist, and actually used in treatment of asthma and consciousness recovery after long period of ane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/05/2010
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19. InvestigaÃÃo da aÃÃo central do carvacrol em modelos de ansiedade, depressÃo e convulsÃo em camundongos e possÃveis mecanismos farmacolÃgicos envolvidos. / Investigation of central actions of carvacrol in animal models of anxiety, depression and convulsion in mice and possible pharmacological mechanisms involved.
Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of anxiety, depression, sedation and convulsion, such as, elevated plus maze (EPM), open field, rota
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/01/2010
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20. Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation
Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50% of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in se
Publicado em: 2010
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21. EFEITO DO TIPO ANTIDEPRESSIVO DO DISSELENETO DE DIFENILA EM UM MODELO DE DEPRESSÃO INDUZIDA POR MALATION EM RATOS / ANTIDEPRESSANT-LIKE EFFECT OF DIPHENYL DISELENIDE ON MALATIONINDUCED DEPRESSION MODEL IN RATS
Organophosphorus (OP), among them malathion, are responsible for most of the poisonings reported annually in Brazil. In addition to symptoms of cholinergic poisoning, the exposure to OP causes affective and cognitive disorders, which are not necessarily related to acetylcholinesterase (AChE) enzyme activity inhibition. One of these disorders is depression. D
Publicado em: 2010
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22. Isolamento e avaliação biológica de compostos fenólicos de espécies de hypericum nativas do sul do Brasil
The pharmacological effects of some Hypericum species are worldwide recognized, mostly by the comproved efficacy of H. perforatum as antidepressant. The south Brazilian species have been showing promissing results. Hypericum polyanthemum and H. caprifoliatum presented antinociceptive effect, while an antidepressant-like activity of H. caprifoliatum was repor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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23. EFEITOS AGUDOS DA ASSOCIAÇÃO DE ETANOL E MINOFILINA EM TESTES COMPORTAMENTAIS E NEUROQUÍMICOS EM CAMUNDONGOS / ACUTE EFFECTS OF THE ASSOCIATION OF ETHANOL ON TESTING AND AMINOPHYLLINE BEHAVIORAL AND NEUROCHEMICAL IN MICE
Ethanol effects in central nervous system (CNS) are due to its action in several neurotransmitter systems, changing the existing balance in inhibitory and excitatory pathways. Aminophylline, a methylxanthine with stimulant action, is an adenosine receptor antagonist, and actually used in treatment of asthma and consciousness recovery after long period of ane
Publicado em: 2010
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24. Estudo comparativo dos efeitos dos Ãleos essenciais de Cymbopogon citratus e Cymbopogon winterianus (POACEAE) no sistema nervoso central de camundongos. / Comparative study of the effect of the essentials oils from Cymbopogon citratus and Cymbopogon winterianus (POACEAE) in the central nervous system of mice.
The main objective of the present work was to study in a comparative manner the effect of two essential oils, isolated from the leaves of Cymbopogon citratus (Cc) and Cymbopogon winterianus (Cw), medicinal herbs that belong to the Poaceae family and are common to the Northeast Region of Brazil. Their EOs effects were studied on the mice central nervous syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2009