Fluphenazine
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. FOTODEGRADATION OF PHENOTHIAZINES AND THEIR STRUCTURAL EFFECTS ON NA(+)K(+) - ATPASE: A FLUORESCENCE STUDY / FOTODEGRADAÇÃO DE FENOTIAZINAS E SEUS EFEITOS ESTRUTURAIS SOBRE A NA(+), K(+) - ATPASE: ESTUDO ATRAVÉS DE FLUORESCÊNCIA
Chlorpromazine (CPZ), fluphenazine (FPZ) and trifluoperazine (TFP) are phenothiazine derivatives, which generate photoproducts under UV irradiation. We observed that CPZ develops three fluorescent fotoproducts under different conditions. Promazine (PZ) that forms from the CPZ photolysis. The chlorine loss is one of the main pathways for photoproduct formatio
Publicado em: 2010
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2. INFLUÊNCIA DO ÔMEGA 3 SOBRE SINTOMAS EXTRAPIRAMIDAIS, DEFICIÊNCIA COGNITIVA E PARÂMETROS DE ESTRESSE OXIDATIVO EM ANIMAIS TRATADOS COM NEUROLÉPTICOS
Haloperidol and fluphenazine are typical neuroleptics widely used in the treatment of mental illness, whose chronic use is associated with adverse effects that affect the motor function and memory, among others. The motor disturbances can be moderate, and include parkinsonism, akathisia, dystonia, but also a more severe syndrome, known as tardive dyskinesia
Publicado em: 2009
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3. ROLE OF DOPAMINE UPTAKE AND THEIR METABOLITES IN THE OROFACIAL DYSKINESIA INDUCED BY NEUROLEPTICS IN RATS / PAPEL DA RECAPTAÇÃO E DE METABÓLITOS DA DOPAMINA NA DISCINESIA OROFACIAL INDUZIDA POR NEUROLÉPTICOS EM RATOS
Fluphenazine-induced orofacial dyskinesia (OD) is a putative animal model of tardive dyskinesia (TD) whose pathophysiology has been related to an increase in dopamine hypersensitivity and oxidative stress. Data from literature have shown that patients with TD present a decrease in dopamine transporter (DAT) expression. In a previously study, we have demonstr
Publicado em: 2008
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4. ASSESSMENT OF THE EFFECTS OF CHRONIC TREATMENT WITH NEUROLEPTICS AND THEIR INTERACTION WITH POTENTIALLY ANTIOXIDANTS SUBSTANCES ON OXIDATIVE STRESS PARAMETERS IN LIVER AND KIDNEY OF RATS / AVALIAÇÃO DOS EFEITOS DO TRATAMENTO CRÔNICO COM NEUROLÉPTICOS E SUA INTERAÇÃO COM SUBSTÂNCIAS POTENCIALMENTE ANTIOXIDANTES SOBRE PARÂMETROS DE ESTRESSE OXIDATIVO NO FÍGADO E RIM DE RATOS
O tratamento com drogas neurolépticas tem sido associado a efeitos colaterais como a discinesia tardia (DT) e o dano hepático. Apesar dos inúmeros casos de hepatotoxicidade após a administração de neurolépticos, são escassos os dados na literatura a respeito desses efeitos e o mecanismo exato pelo qual neurolépticos induzem hepatotoxicidade permanec
Publicado em: 2008
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5. In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs
Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum. Aiming to simulate therapeutic schedules, chloroquine was employed at the concentration used for sensitive falciparum malaria treatment and anti-psycho
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-10
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6. Fluphenazine-resistant Saccharomyces cerevisiae mutants defective in the cell division cycle.
An fls1 mutant of Saccharomyces cerevisiae, which did not grow in the presence of 30 micrograms of fluphenazine per ml, was isolated. Mutants that were resistant to 90 micrograms of fluphenazine per ml and temperature sensitive for growth were obtained from the fls1 mutant. One fluphenazine-resistance mutation, fsr1, was located near the his7 locus on chromo
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7. Welding arc maculopathy and fluphenazine.
A 45-year-old male patient presented with a bilateral maculopathy following unprotected exposure of less than two minutes' duration to a manual metal arc welding unit. He had been receiving the drug fluphenazine for the previous 10 years for treatment of depression. We believe that the drug fluphenazine, which had accumulated in his retinal pigment epitheliu
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8. Fluphenazine induced welding arc maculopathy.
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9. Calcium-regulated phosphorylation in synaptosomal cytosol: dependence on calmodulin.
Calcium stimulated the phosphorylation of several specific synaptosomal cytosolic proteins. The effects of calcium were both concentration and time dependent and were most apparent for proteins with molecular weights of 50,000, 55,000, and 60,000. Exogenous calcium (1.0-100 microM) enhanced the net incorporation of phosphate into protein by as much as 23-fol
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10. Calmodulin activation of plant microsomal Ca2+ uptake
The active ATP-dependent uptake of Ca2+ into a plasma membrane-enriched microsomal fraction from plants is stimulated by the addition of plant as well as bovine brain calmodulin. This stimulation occurs only when the microsomes are prepared in the presence of EDTA. Plant calmodulin also activates the bovine brain 3′,5′-cyclic-nucleotide phosphodiesterase
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11. TAC1, Transcriptional Activator of CDR Genes, Is a New Transcription Factor Involved in the Regulation of Candida albicans ABC Transporters CDR1 and CDR2†
The ABC transporter genes CDR1 and CDR2 can be upregulated in Candida albicans developing resistance to azoles or can be upregulated by exposing cells transiently to drugs such as fluphenazine. The cis-acting drug-responsive element (DRE) present in the promoters of both genes and necessary for their upregulation contains 5′-CGG-3′ triplets that are ofte
American Society for Microbiology.
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12. Comparison of Gene Expression Profiles of Candida albicans Azole-Resistant Clinical Isolates and Laboratory Strains Exposed to Drugs Inducing Multidrug Transporters
Azole resistance in Candida albicans can be due to upregulation of multidrug transporters belonging to ABC (ATP-binding cassette) transporters (CDR1 and CDR2) or major facilitators (CaMDR1). Upregulation of these genes can also be achieved by exposure to fluphenazine, resulting in specific upregulation of CDR1 and CDR2 and by exposure to benomyl, resulting i
American Society for Microbiology.