Fluconazole
Mostrando 1-12 de 850 artigos, teses e dissertações.
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1. Leishmanicidal and Antimicrobial Activities of 4-Quinolone Alkaloids from Stems of the Medicinal Plant Waltheria indica (Malvaceae) and Their Chemotaxonomic Significance
A chemical investigation of the stem of Waltheria indica (Malvaceae) yielded twelve 4-quinolone alkaloids, which were primarily waltheriones. These were waltherione A (1), waltherione B (2), waltherione C (3), waltherione G (4), waltherione H (5), waltherione J (6), waltherione L (7), waltherione P (8), chamaedrone (9), 8-deoxy-antidesmone (10), antidesmone
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Design, Synthesis and Antifungal Activity of New Schiff Bases Bearing 2-Aminothiophene Derivatives Obtained by Molecular Simplification
Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their druglikeness and pharmacokinetic properties, establishment of their structure-activity relationships (SAR), a
J. Braz. Chem. Soc.. Publicado em: 2021-05
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3. Synergic effect of simvastatin in combination with amphotericin B against environmental strains of Cryptococcus neoformans from northeastern Brazil: a prospective experimental study
BACKGROUND: Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects. OBJECTIVE: To evaluate synergic interactions between simvastatin and both amphotericin B and fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds’ droppings. DESIGNAND SETTING: Experimental study cond
Sao Paulo Med. J.. Publicado em: 2020-02
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4. Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017
ABSTRACT Background: This study aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis from 2013 to 2017 in a major teaching hospital in China. Methods: Trends in antifungal drug susceptibility of 217 consecutive non-repetitive cryptococcal isolates collected from patients of an university hospital in China were ana
Braz J Infect Dis. Publicado em: 2020-02
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5. An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient
ABSTRACT Cryptococcosis is an opportunistic fungal infection causes significant disease predominantly in immunocompromised patients. Here we present an excepcional case of disseminated cryptococcosis with pulmonary and cerebral involvement in an immunocompetent patient with no apparent predisposing factors at the time of hospital admission. We described a ca
Rev. Inst. Med. trop. S. Paulo. Publicado em: 17/01/2020
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6. Multidrug-resistant Candida glabrata strains obtained by induction of anidulafungin resistance in planktonic and biofilm cells
Candida glabrata has emerged as a common cause of serious life-threatening fungal infections, largely owing to their low susceptibility to azole antifungals. Recent guidance indicates the use of echinocandins as the first-choice drug for the treatment of systemic infections of C. glabrata; however, C. glabrata resistance to echinocandins is reportedly increa
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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7. Antifungal effect of sesame medicinal herb on Candida Species: original study and mini-review
The aim of this study was to evaluate the antifungal susceptibility patterns of three antifungals, methanolic extracts and N-hexane oil of sesame seeds on C. albicans and C. glabrata, isolated from oral cavity of liver transplant recipients. The results were compared with other reports to develop a mini review as well. Candida species were isolated from live
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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8. Fusarium solani keratitis: role of antifungal susceptibility testing and identification to the species level for proper management
ABSTRACT We report a patient with fungal keratitis caused by a multiresistant Fusarium solani in a tertiary care hospital located in southern Brazil. A 55-year-old man with a history of ocular trauma presented with keratitis in left eye. The patient has a complicated clinical course and failed to respond to local and systemic antifungal treatment, and requir
Braz J Infect Dis. Publicado em: 09/09/2019
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9. Candida albicans Clinical Isolates from a Southwest Brazilian Tertiary Hospital Exhibit MFS-mediated Azole Resistance Profile
Abstract: Candida albicans is the most frequent fungal species that causes infections in humans. Fluconazole is the main antifungal used to treat Candida infections, and its prolonged and indiscriminate use for the last decades are the most established causes which originated resistant strains. Fungal drug resistance is associated to alterations in ERG11 gen
An. Acad. Bras. Ciênc.. Publicado em: 29/07/2019
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10. Yeasts isolated from tropical fruit ice creams: diversity, antifungal susceptibility and adherence to buccal epithelial cells
Resumo Os sorvetes à base de frutas são produtos amplamente consumidos em países tropicais e, devido à sua composição, podem ser uma boa fonte de crescimento microbiano, incluindo patógenos oportunistas. Os objetivos deste estudo foram caracterizar as populações de leveduras presentes nos sorvetes brasileiros à base de frutas e investigar sua susce
Braz. J. Food Technol.. Publicado em: 04/07/2019
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11. Histatin 5 and human lactoferrin inhibit biofilm formation of a fluconazole resistant Candida albicans clinical isolate
Abstract:Candida albicans is the most important fungal pathogen that causes infections in humans. Biofilms are hard-to-treat structures due to their high antifungal resistance. Saliva is a fluid that contains antimicrobial substances acting as the first-line of defense against pathogens, and its immune components may be potential tools for the discovery of n
An. Acad. Bras. Ciênc.. Publicado em: 08/04/2019
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12. First case report of cryptococcosis due to Cryptococcus decagattii in a pediatric patient in Argentina
Abstract We report the first case of cryptococcosis due to Cryptococcus decagattii in an immunocompetent pediatric patient from an indigenous community in Argentina with a successful outcome. Two isolates (blood, cerebrospinal fluid) were genotyped by restriction fragment length polymorphism of the orotidine monophosphate pyrophosphorylase (URA5) gene as VGI
Rev. Soc. Bras. Med. Trop.. Publicado em: 28/03/2019