Fear Extinction
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. New frontiers in the study of memory mechanisms
We review recent work on three major lines of memory research: a) the possible role of the protein kinase M-zeta (PKMzeta) in memory persistence; b) the processes of “synaptic tagging and capture” in memory formation; c) the modulation of extinction learning, widely used in the psychotherapy of fear memories under the name of “exposure therapy”. PKMz
Rev. Bras. Psiquiatr.. Publicado em: 2013-06
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2. ATUAÇÃO DO NÚCLEO INCERTUS NA AQUISIÇÃO E EXTINÇÃO DE MEMÓRIAS DE MEDO CONDICIONADO. / CORE PERFORMANCE IN THE ACQUISITION AND EXTINCTION INCERTUS OF MEMORIES OF FEAR CONDITIONING.
A pesquisa dos mecanismos neurais relacionados à formação das emoções tem crescido nos últimos anos. O medo é um comportamento originado em resposta aos perigos enfrentados pelos animais, tendo sua origem nas reações defensivas exibidas quando da exposição a estímulos ameaçadores. A memória do medo ajuda os animais e os seres humanos a reconhec
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/08/2012
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3. A participação de diferentes sistemas neuromodulatórios no hipocampo, núcleo basolateral da amígdala e córtex pré-frontal ventromedial na extinção de memórias aversivas
Extinction consists of the learned inhibition of retrieval of previously acquired memory. Many forms of learning are modulated by ¿-noradrenergic, D1-dopaminergic and H2-histaminergic receptors on ventromedial prefrontal cortex (vmPFC), basolateral amygdala (BLA) and dorsal hippocampus. Therefore, the aim of this work was investigated the modulation of aver
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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4. Treatment of fear memories: interactions between extinction and reconsolidation
A evocação labiliza os arquivos de memória, e isto permite dois processos dependentes de síntese protéica no cérebro: a extinção, que inibe a evocação ulterior, e a reconsolidação, que pode aumentar a evocação ou mudar seu conteúdo. A extinção pode por sua vez sofrer reconsolidação. Interações entre estes dois processos podem ser aplicad
Anais da Academia Brasileira de Ciências. Publicado em: 2011-12
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5. Memória emocional de ratos selecionados no campo aberto em alto e baixo rearing: aquisição, consolidação e extinção no condicionamento de medo / Emotional memory of rats in open field in selected high and low rearing: acquisition, consolidation and extinction in fear conditioning
O comportamento de rearing apresenta papel fundamental na exploração, sendo considerado mais eficiente na busca e introjeção de informações do ambiente do que outros comportamentos exploratórios. A formação hipocampal parece ser a estrutura neural envolvida na inter-relação entre rearing, formação de mapas cognitivos e emocionalidade. Além diss
Publicado em: 2010
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6. POLIAMINERGIC AGENTS MODULATE CONTEXTUAL FEAR EXTINCTION IN RATS / AGENTES POLIAMINÉRGICOS MODULAM A EXTINÇÃO DO MEDO CONDICIONADO CONTEXTUAL EM RATOS
Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-D-aspartate receptors (NMDAr). However whether polyamine agonists and antagonists alter extinction remains unclear. In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B su
Publicado em: 2009
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7. Modelação temporal de processos de aprendizagem : Implicações praticas e teoricas
Studies that analyze a temporal variation in learning and memory processes are relatively scattered and inconsistent, mainly due to the lack of systematic methods and specifications of the necessary controls that would allow the dissection of a temporal component in the learning process per se. Here we analyze the difficulties of this kind of study and sugge
Publicado em: 1999
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8. Adrenergic Transmission Facilitates Extinction of Conditional Fear in Mice
Extinction of classically conditioned fear, like its acquisition, is active learning, but little is known about its molecular mechanisms. We recently reported that temporal massing of conditional stimulus (CS) presentations improves extinction memory acquisition, and suggested that temporal spacing was less effective because individual CS exposures trigger t
Cold Spring Harbor Laboratory Press.
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9. Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction
There is a growing body of evidence that the hippocampus is critical for context-dependent memory retrieval. In the present study, we used Pavlovian fear conditioning in rats to examine the role of the dorsal hippocampus (DH) in the context-specific expression of fear memory after extinction (i.e., renewal). Pre-training electrolytic lesions of the DH blunte
Cold Spring Harbor Laboratory Press.
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10. Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice
Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Based on previous data indicating that fear extinction in rats is blocked by quinpirole, an agonist of dopamine D2 receptors, we hypothesized that blockad
Cold Spring Harbor Laboratory Press.
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11. Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear
After extinction of conditioned fear, memory for the conditioning and extinction experiences becomes context dependent. Fear is suppressed in the extinction context, but renews in other contexts. This study characterizes the neural circuitry underlying the context-dependent retrieval of extinguished fear memories using c-Fos immunohistochemistry. After fear
Cold Spring Harbor Laboratory Press.
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12. Memory for Extinction of Conditioned Fear Is Long-lasting and Persists Following Spontaneous Recovery
Conditioned fear responses to a tone paired with footshock rapidly extinguish when the tone is presented in the absence of the shock. Rather than erase conditioning, extinction is thought to involve the formation of new memory. In support of this, extinguished freezing spontaneously recovers with the passage of time. It is not known, however, how long extinc
Cold Spring Harbor Laboratory Press.