Fat Oxidation Lipogenesis
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Renin-angiotensin system blockers regulate the metabolism of isolated fat cells in vitro
Due to the presence of the renin-angiotensin system (RAS) in tissues and its specific influence on white adipose tissue, fat cells are possible targets of pharmacological RAS blockers commonly used as anti-hypertensive drugs. In the present study, we investigated the effects of different RAS blockers on fat cell metabolism, more specifically on lipolysis, li
Braz J Med Biol Res. Publicado em: 28/07/2016
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2. Efeitos do treinamento resistido sobre a expressão gênica de moléculas envolvidas na oxidação de gordura e na lipogênese no fígado de ratas ovariectomizadas
A deficiência de estrógeno está associada à esteatose hepática (EH), por meio de alteração na expressão gênica de moléculas relacionadas à oxidação de gordura e à lipogênese. Tanto o treinamento resistido (TR), quanto o treinamento de endurance (TE) previne a EH em ratas ovariectomizadas (Ovx). No entanto, os eventos moleculares somente foram
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/06/2011
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3. Efeito do fenofibrato sobre o metabolismo de ratos com ou sem indução de esteatose hepática
The experiments reported here were designed to study the effect of fenofibrate (stimulant of peroxisome proliferator-activated receptor á - PPARá) and hepatic steatosis induced by orotic acid administration on the metabolism of adipose tissue and liver. Wistar male rats were divided into 4 experimental groups: 1) fed a balanced diet (C); 2) fed a balanced
Publicado em: 2007
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4. Mechanisms of nutritional and hormonal regulation of lipogenesis
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids a
Oxford University Press.
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5. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection.
Short-term alterations in dietary carbohydrate (CHO) energy are known to alter whole-body fuel selection in humans, but the metabolic mechanisms remain unknown. We used stable isotope-mass spectrometric methods with indirect calorimetry in normal subjects to quantify the metabolic response to six dietary phases (5 d each), ranging from 50% surplus CHO (+50%
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6. Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance
Low-fat, high-carbohydrate (LF/HC) diets commonly elevate plasma triglyceride (TG) concentrations, but the kinetic mechanisms responsible for this effect remain uncertain. Subjects with low TG (normolipidemic [NL]) and those with moderately elevated TG (hypertriglyceridemic [HTG]) were studied on both a control and an LF/HC diet. We measured VLDL particle an
American Society for Clinical Investigation.
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7. Re-evaluation of Sepharose-insulin as a tool for the study of insulin action.
The biological activity of Sepharose-insulin in different assays in vitro, e.g., stimulation of glucose oxidation, lipogenesis, and antilipolysis and activation of pyruvate dehydrogenase (EC 1.2.4.1) activity, has been investigated. According to amino acid analysis, between 270 and 330 mug (6.9-8.2 U) of insulin were coupled per ml of packed beads. Related t
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8. Depot-specific effects of the PPARγ agonist rosiglitazone on adipose tissue glucose uptake and metabolisms⃞
We investigated mechanisms whereby peroxisome proliferator-activated receptor γ (PPARγ) agonism redistributes lipid from visceral (VF) toward subcutaneous fat (SF) by studying the impact of PPARγ activation on VF and SF glucose uptake and metabolism, lipogenesis, and enzymes involved in triacylglycerol (TAG) synthesis. VF (retroperitoneal) and SF (inguina
American Society for Biochemistry and Molecular Biology.
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9. The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity*
Obesity and type 2 diabetes are related metabolic disorders of high prevalence. The constitutive androstane receptor (CAR) was initially characterized as a xenobiotic receptor regulating the responses of mammals to xenotoxicants. In this study, we have uncovered an unexpected role of CAR in preventing obesity and alleviating type 2 diabetes. Using a high fat
American Society for Biochemistry and Molecular Biology.
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10. Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression study
Obesity is a leading cause of diabetes mellitus and hypertension. Molecular signals produced by adipose tissue may contribute to the pathogenesis of these two disorders. We showed previously that a specific segment of rat chromosome 20 (RNO20) contains a gene(s) regulating the degree of obesity, glucose intolerance, and hypertension in response to a chronic
American Physiological Society.
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11. Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers.
The relationship between thermogenic and potentially atherogenic effects of cigarette smoking (CS) and its cessation was investigated. Heavy smokers (n = 7, serum cotinine > 200 ng/ml, > 20 cigarettes/d) were maintained on isoenergetic, constant diets for 2 wk, 1 wk with and 1 wk without CS. Stable isotope infusions with indirect calorimetry were performed o
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12. In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose.
Studies were conducted to determine whether the direction of hepatic carbohydrate and lipid metabolism in the rat could be switched simultaneously from a "fasted" to a "fed" profile in vitro. When incubated for 2 h under appropriate conditions hepatocytes from fasted animals could be induced to synthesize glycogen at in vivo rates. There was concomitant mark