Fasl Cd95l
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. Papel dos receptores do tipo Toll na morte celular induzida por ativação (AICD) de linfócitos T. / Role of Toll-Like receptors in the activation-induced cell death (AICD) of T cells hybridoma.
During an infection the number of T lymphocytes increases dramatically. The clonal expansion phase is followed by reducing the level of activated T cells that depends, in part, a process of cell death induced by activation (AICD). Our group showed that when APCs are stimulated with LPS, a TLR4 agonist, produce PGE2, which inhibits the AICD of CD4 + T cells b
Publicado em: 2009
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2. Expressão de marcadores de poptose e de Foxp3 nas diferentes formas clínicas da Leishmaniose Tegumentar Americana
Considerando o papel importante da apoptose e da célula T reguladora (Treg) na modulação da resposta imune, o objetivo deste estudo foi avaliar a expressão de proteínas envolvidas na apoptose e a expressão do fator de transcrição Foxp3 (marcador da célula Treg) em amostras de biópsia das diferentes formas clínicas da LTA (leishmaniose tegumentar a
Publicado em: 2009
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3. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.
Although anatomical barriers and soluble mediators have been implicated in immune privilege, it appears that the apoptotic cell death of Fas+ cells by tissue-associated CD95 ligand (Fas ligand, FasL) is an important component. One clinical example of the function of an immune privileged site is the success of human corneal transplants, where a very high perc
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4. Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion
Peripheral lymphocyte deletion is required for reduction of lymphocyte numbers after expansion in response to antigen. Peripheral deletion is mediated in part by the activation of apoptosis by engagement of the death receptor, Fas (CD95), by its ligand, Fas ligand (FasL; CD95L), among other mechanisms. Here we used T cell receptor (TCR) transgenic animals to
National Academy of Sciences.
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5. Expression of Fas (CD95/APO-1) Ligand by Human Breast Cancers: Significance for Tumor Immune Privilege
Breast cancers have been shown to elicit tumor-specific immune responses. As in other types of cancer, the antitumor immune response fails to contain breast tumor growth, and a reduction in both the quantity and cytotoxic effectiveness of tumor-infiltrating lymphocytes (TILs) is associated with a poorer prognosis. Fas ligand (FasL) induces apoptotic dea
American Society for Microbiology.
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6. Proteasome regulation of activation-induced T cell death
Lactacystin, a microbial metabolite that inhibits protease activity only in the proteasome, was used to study the role of the proteasome in the activation-induced cell death (AICD) of T cells. Lactacystin induces DNA fragmentation and apoptosis in a T cell hybridoma (DO.11.10) in a dose-dependent manner. Between 1 and 10 μM, the mildly cytotoxic lactacystin
The National Academy of Sciences of the USA.
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7. Fas (CD95)-Fas Ligand Interactions Are Responsible for Monocyte Apoptosis Occurring as a Result of Phagocytosis and Killing of Staphylococcus aureus
Human peripheral blood monocytes become apoptotic following phagocytosis of Staphylococcus aureus. In this study, we investigated the mechanisms involved in this phenomenon. Cells exposed to bacteria were examined for the surface expression of Fas and Fas ligand (FasL). The level of soluble form of FasL was also measured in the culture supernatants. As Fas-m
American Society for Microbiology.
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8. Polymorphism of murine Fas ligand that affects the biological activity
Fas ligand (FasL) is a member of the tumor necrosis factor family and induces apoptosis in Fas (CD95)-bearing target cells. In this study, we generated several mAbs that react with mouse FasL (mFasL) and characterized their functional properties. One of these mAbs, K10, specifically reacted with mFasL derived from C57BL/6 (B6) mice, but not that from BALB/c
The National Academy of Sciences of the USA.
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9. Sustained Lipopolysaccharide-Induced Lung Inflammation in Mice Is Attenuated by Functional Deficiency of the Fas/Fas Ligand System
To determine whether the Fas/Fas ligand (FasL) (CD95/CD178) system contributes to the development of an inflammatory response in vivo, 2.5 μg of bacterial lipopolysaccharide (LPS; endotoxin) per g was administered intranasally to healthy mice (C57BL/6) and mutant mice deficient in either Fas (lpr mice) or FasL (gld mice). Sustained LPS-induced neutrophilic
American Society for Microbiology.
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10. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes.
Apoptosis has been proposed to mediate CD4+ T-cell depletion in human immunodeficiency virus (HIV)-infected individuals. Interaction of Fas ligand (FasL) with Fas (CD95) results in lymphocyte apoptosis, and increased susceptibility to Fas-mediated apoptosis has been demonstrated in lymphocytes from HIV-infected individuals. Cells undergoing apoptosis in lymp
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11. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.
Both rheumatoid arthritis and animal models of autoimmune arthritis are characterized by hyperactivation of synovial cells and hyperplasia of the synovial membrane. The activated synovial cells produce inflammatory cytokines and degradative enzymes that lead to destruction of cartilage and bones. Effective treatment of arthritis may require elimination of mo
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12. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?
Astrocytomas are among the most common brain tumors that are usually fatal in their malignant form. They appear to progress without significant impedance from the immune system, despite the presence of intratumoral T cell infiltration. To date, this has been thought to be the result of T cell immunosuppression induced by astrocytoma-derived cytokines. Here,