Extrinsic Repair
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom
Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/05/2013
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2. Laparoendoscopic Single-site Repair of Retrocaval Ureter Without any Special Devices
INTRODUCTIONThe retrocaval ureter is a rare congenital anomaly. The extrinsic compression may be responsible for obstruction and pain symptoms. The laparoscopic approach has been used with good results and less morbidity than the open surgery. Herein we describe a case of retrocaval ureter treated with LESS. To our knowledge, this represents the second such
Int. braz j urol.. Publicado em: 2013-01
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3. REPAROS E AJUSTES AUTOMÁTICOS DE CIRCUITOS ELETRÔNICOS ATRAVÉS DE ELETRÔNICA EVOLUCIONÁRIA / REPARACIONES Y AJUSTES AUTOMÁTICOS DE CIRCUITOS ELECTRÓNICOS A TRAVÉS DE ELECTRÓNICA EVOLUTIVA / EVOLVABLE AUTOMATIC REPAIR AND ADJUSTMENT OF ELECTRONIC CIRCUITS
Esta disertación investiga la utilización de técnicas de electrónica Evolutiva en los procesos de reparación y ajuste de circuitos electrónicos. El objetivo del trabajo fue evaluar el desempeño de algoritmos de computación evolutiva en la reparación de circuitos electrónicos defectuosos y en el ajuste y mejoría de los circuitos no óptimos, ofreci
Publicado em: 2001
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4. BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair
Intracellular oxidative stress in cells transformed by the BCR-ABL oncogene is associated with increased DNA double-strand breaks. Imprecise repair of these breaks can result in the accumulation of mutations, leading to therapy-related drug resistance and disease progression. Using several BCR-ABL model systems, we found that BCR-ABL specifically promotes th
American Society of Hematology.
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5. The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast
During the course of meiotic prophase, intrinsic double-strand breaks (DSBs) must be repaired before the cell can engage in meiotic nuclear division. Here we investigate the mechanism that controls the meiotic progression in Schizosaccharomyces pombe that have accumulated excess meiotic DSBs. A meiotic recombination-defective mutant, meu13Δ, shows a delay i
Oxford University Press.
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6. Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage
We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent phosphorylation of p53 without changing p53 protein levels, indicating that p53 activity can be regulated without an Mdm2-like activity. In a genome-wide analysis of
American Society for Microbiology.
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7. Rad18 Is Required for DNA Repair and Checkpoint Responses in Fission Yeast
To survive damage to the genome, cells must respond by activating both DNA repair and checkpoint responses. Using genetic screens in the fission yeast Schizosaccharomyces pombe, we recently isolated new genes required for DNA damage checkpoint control. We show here that one of these strains defines a new allele of the previously described rad18 gene, rad18-7
The American Society for Cell Biology.
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8. Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exhibits specific tumoricidal activity and is under development for cancer therapy. Mismatch-repair-deficient colonic tumors evade TRAIL-induced apoptosis through mutational inactivation of Bax, but chemotherapeutics including Camptosar (CPT-11) restore TRAIL sensitivity. However, the signaling
National Academy of Sciences.