Experimental Sporotrichosis
Mostrando 1-12 de 12 artigos, teses e dissertações.
-
1. Esporotricose sistêmica experimental: Avaliação in vivo da ¿ (1-3) glucana em associação ao itraconazol em modelo murino / Experimental systemic sporotrichosis: evaluation in vivo _ (1-3) glucan and in association to itraconazole in murine model
A esporotricose, micose subcutânea causada pelo fungo dimórfico Sporothrix schenckii, acomete o homem e várias espécies de animais, sendo os felinos domésticos a espécie mais comumente envolvida nos relatos zoonóticos da enfermidade. Considerando as dificuldades terapêuticas no tratamento da micose, incluindo toxicidade e o desenvolvimento de resist�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
2. Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis
Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of te
Publicado em: 2010
-
3. Development of experimental sporothichosis in a murine model with yeast and mycelial froms of Sporothrix schenckii / Avaliação do desenvolvimento da esporotricose experimental em camundongos com as formas leveduriforme e filamentosa do Sporothrix schenckii
A esporotricose é uma micose subcutânea causada pelo fungo dimórfico Sporothrix schenckii que acomete o homem e uma grande variedade de animais. Este trabalho teve como objetivos verificar possíveis diferenças de virulência entre inóculos das formas leveduriforme (Y) e filamentosa (M), comparar as reações induzidas pelos dois inóculos em diferentes
Publicado em: 2010
-
4. Production and evaluation of albino mutants of Sprorothrix schenckii / Produção e avaliação de mutantes albinos de Sporothrix schenckii
Melanin is an important factor intrinsically related to the virulence of the Sporothrix schenckii. Mutant albino conidia are usually used as inoculants for the evaluation of the properties of melanin in experimental models for the study of sporotrichosis. The goals of this study were to analyze the presence of melanin in S. schenckii conidia, and to produce
Publicado em: 2010
-
5. Esporotricose experimental sistêmica em ratos Wistar: avaliação hematológica e perfil hepático
Alanine aminotransferase (ALT) and alkaline phosphatase (AP) hepatic enzymes, hematological values, and total plasmatic proteins (TPP) of 12 Wistar rats with systemic experimental sporotrichosis were evaluated. Inoculation was performed at 2x10³ cells of S. schenckii/ml. The values ranged from 35 to 48UI/l for ALT and 67 to 251.3UI/l for AP. Fifty percent o
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2008-08
-
6. Evaluation of the immunemodulator (1-3) glucan use isolated and in association to itraconazole in the experimental sporotrichosis / Avaliação do uso do imunomodulador (1-3) glucana isoladamente e em associação ao Itraconazol na esporotricose experimental
The sporotrichosis, subcutaneous mycosis caused by the fungus dimorphic Sporothrix schenckii, can infect the man and several species of animals. The domestic felines are involved in the zoonotic reports of this illness. Considering the therapeutic difficulties in the treatment of this mycosis in felines, including toxicity and the resistance development to t
Publicado em: 2008
-
7. Case study spontaneous of canine and feline sporotrichosis, and evaluation of the melanin in cells of Sporothrix schenckii in model murine / Estudo de casos espontâneos de esporotricose canina e felina, e avaliação da melanina em células de Sporothrix schenckii em modelo murino
Sporotrichosis is a zoonotic mycosis, caused by dimorphic fungus Sporothrix schenckii, that attacks the man and several animal species, especially domestic felines. Among the factors of patogenicity of the fungus, stands out the melanin presence. This work had as objective: to study spontaneous cases of esporotricose in canine and felines, evaluating the asp
Publicado em: 2007
-
8. Experimental Therapy of Cladosporiosis and Sporotrichosis with 5-Fluorocytosine
Cladosporium trichoides and Sporothrix schenckii are fungi known to be pathogenic for man. No effective chemotherapy is available for cladosporiosis, and systemic sporotrichosis can be very resistant to antifungal chemotherapy. Experimental infections of mice with these fungi resembled their respective infections in man and provided a model for evaluating a
-
9. Efficacies of four antifungal agents in experimental murine sporotrichosis.
Four antifungal agents, amphotericin B, SDZ 89-485, itraconazole, and terbinafine, were tested for efficacy in a murine model of systemic sporotrichosis. Survival in the groups treated with amphotericin B, SDZ 89-485, and itraconazole was significantly better than that of control infected mice. However, these agents did not wholly protect the infected mice,
-
10. Experimental sporotrichosis in Syrian hamsters.
Syrian hamsters were infected with Sporothrix schenckii by subcutaneous footpad inoculation. Two types of infection could be uniformly induced: a self-limited, lymphatic infection resembling the classical disease in humans, and a generalized nonfatal infection. An infecting dose of approximately 5,300 yeast cells produced the localized subcutaneous-lymphatic
-
11. COMPARISON OF STRAINS OF SPOROTRICHUM SCHENCKII ISOLATED FROM NATURE1
Howard, Dexter H. (University of California, Los Angeles) and G. F. Orr. Comparison of strains of Sporotrichum schenckii isolated from nature. J. Bacteriol. 85:816–821. 1963.—Several strains of fungi, tentatively considered to be members of the genus Sporotrichum, have been isolated from soil and from other sources in nature. The striking morphological s
-
12. Response of macrophage Toll-like receptor 4 to a Sporothrix schenckii lipid extract during experimental sporotrichosis
Toll-like receptors have been implicated in the recognition of various pathogens, including bacteria, viruses, protozoa and fungi. However, no information is available about Toll-like receptor 4 (TLR4) participation in Sporothrix schenckii recognition and the consequent triggering of the immune response to this fungal pathogen. Following activation of TLRs b
Blackwell Science Inc.